Roger Traub, MD and Miles Whittington, PhD
- Published in print:
- 2010
- Published Online:
- May 2010
- ISBN:
- 9780195342796
- eISBN:
- 9780199776276
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195342796.001.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems, Development
This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions ...
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This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions between neurons – mediated by both chemical synapses and by gap junctions – can lead to oscillations in populations of cells. The discussion is based largely on data derived from in vitro systems (hippocampus, cerebral and cerebellar cortex) and from network modeling. Finally, the book considers how brain oscillations can provide insight into normal brain function as well as pathophysiology.Less
This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions between neurons – mediated by both chemical synapses and by gap junctions – can lead to oscillations in populations of cells. The discussion is based largely on data derived from in vitro systems (hippocampus, cerebral and cerebellar cortex) and from network modeling. Finally, the book considers how brain oscillations can provide insight into normal brain function as well as pathophysiology.
Roger D. Roger and Miles A. Whittington
- Published in print:
- 2010
- Published Online:
- May 2010
- ISBN:
- 9780195342796
- eISBN:
- 9780199776276
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195342796.003.0010
- Subject:
- Neuroscience, Molecular and Cellular Systems, Development
VFO occurs in in vitro models when chemical receptors are blocked. In particular, VFO does not require GABAA receptors, even though interneurons fire at high rates during in vivo very fast ...
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VFO occurs in in vitro models when chemical receptors are blocked. In particular, VFO does not require GABAA receptors, even though interneurons fire at high rates during in vivo very fast oscillations. VFO can be accounted for by a model in which neuronal spiking percolates through a sparse network of electrically coupled axons. This model predicts that VFO frequency depends on gap junction conductance, mediated by an effect on crossing time (i.e. the time it takes for a spike in one axon to elicit a spike in a coupled axon, estimated to be of order 0.2 ms). VFO in cerebellar slices also depends on gap junctions, but the physical principles are slightly different: cerebellar VFO appears to depend on many:one propagation of spiking, in effect a form of axonal coincidence detection.Less
VFO occurs in in vitro models when chemical receptors are blocked. In particular, VFO does not require GABAA receptors, even though interneurons fire at high rates during in vivo very fast oscillations. VFO can be accounted for by a model in which neuronal spiking percolates through a sparse network of electrically coupled axons. This model predicts that VFO frequency depends on gap junction conductance, mediated by an effect on crossing time (i.e. the time it takes for a spike in one axon to elicit a spike in a coupled axon, estimated to be of order 0.2 ms). VFO in cerebellar slices also depends on gap junctions, but the physical principles are slightly different: cerebellar VFO appears to depend on many:one propagation of spiking, in effect a form of axonal coincidence detection.
Roger D. Roger and Miles A. Whittington
- Published in print:
- 2010
- Published Online:
- May 2010
- ISBN:
- 9780195342796
- eISBN:
- 9780199776276
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195342796.003.0004
- Subject:
- Neuroscience, Molecular and Cellular Systems, Development
Epilepsy can be viewed from inter-related clinical and electrical/cellular points of view. Before and during a so-called electrographic seizure, neuronal events become both highly correlated ...
More
Epilepsy can be viewed from inter-related clinical and electrical/cellular points of view. Before and during a so-called electrographic seizure, neuronal events become both highly correlated (synchronized) and also organized in time. The latter organization occurs over a wide range of frequencies. Prior to seizures, very fast oscillations (VFO, >70-80 Hz) occur, that are dependent on gap junctions. Understanding how VFO is generated may provide a therapeutic target.Less
Epilepsy can be viewed from inter-related clinical and electrical/cellular points of view. Before and during a so-called electrographic seizure, neuronal events become both highly correlated (synchronized) and also organized in time. The latter organization occurs over a wide range of frequencies. Prior to seizures, very fast oscillations (VFO, >70-80 Hz) occur, that are dependent on gap junctions. Understanding how VFO is generated may provide a therapeutic target.
