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Theoretical underpinning for the use of twin studies in life course epidemiology

Ruth J F Loos, Charlotte L Ridgway, and Ken K Ong

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0004
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The classical twin design is used in genetic epidemiology to estimate the heritability of a trait or disease. Despite potential biases for certain traits at specific stages during the life course, ... More


Family-based studies applied to the influence of early life factors on cardiovascular disease

Debbie A Lawlor and David A Leon

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0013
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

There is good evidence that associations exist between fetal and other early life factors and subsequent risk of cardiovascular disease (CVD) that can be replicated in a range of settings. These ... More


Random effects models for sibling and twin-based studies in life course epidemiology

Samuli Ripatti

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0011
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter introduces statistical methods for twin and sibling studies using random effects models. The classic twin study begins from assessing the variance of a trait (called a phenotype by ... More


Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Deborah A. Lawlor and Gita D. Mishra (eds)

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.001.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Family based studies, including intergenerational, sibling and twin studies, are increasingly used to explore life course epidemiology. However, understanding the underlying assumptions of these ... More


Mirror, Mirror …

William R. Clark and Michael Grunstein

in Are We Hardwired?: The Role of Genes in Human Behavior

Published in print:
2004
Published Online:
April 2010
ISBN:
9780195178005
eISBN:
9780199893331
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195178005.003.0001
Subject:
Biology, Evolutionary Biology / Genetics

This chapter looks in detail at the study of human behavior in twins, fraternal and identical. Of particular interest are studies of genetically identical twins separated at birth and raised in ... More


Discussant chapter—summary of the theoretical approaches to family-based studies in life course epidemiology

Hazel M Inskip

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0005
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Chapters 2 to 4 describe three specific approaches to family studies, namely, intergenerational, sibling, and twin studies. All can be used to assist in distinguishing between genetic and ... More


Discussant chapter—statistical considerations in family-based life course studies

Amanda Sacker

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0012
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter summarizes some of the issues that have been described in the previous two chapters on statistical considerations in family studies. It highlights some of the assumptions underlying the ... More


Family-based life course studies in low- and middle-income countries

G David Batty, Cesar G Victora, and Debbie A Lawlor

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0007
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter briefly describes the growing impact of non-communicable disease in low- and middle-income countries (LMIC) which, together with existing infectious illnesses and a rising incidence of ... More


Discussant chapter—using family-based designs in life course epidemiology

John Lynch and Seungmi Yang

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0016
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The three chapters in this section offer different but complementary conceptualizations of ‘family’. Morton and Rich Edwards used ‘family’ to document inter-generational concordance of reproductive ... More


Genetic and Environmental Influences on Individual Differences in Language and Theory of Mind: Common or Distinct?

Claire Hughes

in Why Language Matters for Theory of Mind

Published in print:
2005
Published Online:
March 2012
ISBN:
9780195159912
eISBN:
9780199847150
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195159912.003.0015
Subject:
Psychology, Cognitive Psychology

This chapter presents data from two twin studies conducted at two different times in development—3;6 years and 5;0 years. Both studies showed a strong correlation between general verbal ability and ... More


New frontiers in genetic influences on cognitive aging

Nancy L. Pedersen

in New Frontiers in Cognitive Aging

Published in print:
2004
Published Online:
March 2012
ISBN:
9780198525691
eISBN:
9780191689369
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198525691.003.0012
Subject:
Psychology, Cognitive Psychology

During the past thirty years considerable strides have been made in demonstrating that genetic effects are of importance for cognitive abilities. The first steps taken were typically to demonstrate ... More


How family-based studies have added to the understanding of life course epidemiology of mental health

Stephani L Hatch and Gita D Mishra

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0014
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter reviews some of the key family-based studies that have identified links between various illnesses and behaviours in parents and siblings with psychiatric disorders in study members. It ... More


Methodology of quantitative behavior and molecular genetics

Susan C. South and Amber M. Jarnecke

in Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.003.0003
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

Within the social and behavioral sciences, there is a long history of the study of genetic and environmental influences on individual differences between people. This chapter provides an overview of ... More


Epigenetics and twin studies: A review and applications in human aggressive behavior

Jenny van Dongen and Dorret I Boomsma

in Genes, brain, and emotions: Interdisciplinary and Translational Perspectives

Published in print:
2019
Published Online:
June 2019
ISBN:
9780198793014
eISBN:
9780191834745
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198793014.003.0004
Subject:
Neuroscience, Development, Disorders of the Nervous System

Throughout life, human traits are characterized by variability: they show variation between people and within persons over a time period. Such variation between and within persons can be related to ... More


Life course approaches to the genetic epidemiology of mental illness

Elise B. Robinson, Lauren M. McGrath, and Susan L. Santangelo

in A Life Course Approach to Mental Disorders

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199657018
eISBN:
9780191748097
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199657018.003.0018
Subject:
Public Health and Epidemiology, Public Health

Most genetic studies in psychiatry employ cross-sectional, case–control designs. Focusing on twin and family studies, this chapter introduces evidence in support of three developmentally sensitive ... More


Are We Hardwired?: The Role of Genes in Human Behavior

William R. Clark and Michael Grunstein

Published in print:
2004
Published Online:
April 2010
ISBN:
9780195178005
eISBN:
9780199893331
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195178005.001.0001
Subject:
Biology, Evolutionary Biology / Genetics

The role of genes in governing behavior remains one of the most controversial topics in human biology. Early in this century, over-eager promotion of a genetic basis for behavior led to the excesses, ... More


Why family matters: an introduction

Debbie A Lawlor and Gita D Mishra

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Family characteristics and interactions can directly affect one's health and wellbeing across the life course. In addition to the importance of recruiting and collecting data on family members, ... More


The future of family-based studies in life course epidemiology: challenges and opportunities

Gita D Mishra and Debbie A Lawlor

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0017
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Family-based studies can provide a more comprehensive view of life course epidemiology than studies that do not engage with family effects. They can establish intergenerational associations, help to ... More


The heritability of subjective well-being: review and meta-analysis

Ragnhild Bang Nes and Espen Røysamb

in Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.003.0005
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

Why do people differ in their happiness and well-being? Over the last decade, behavior geneticists have tried to resolve whether variation in happiness is a family matter, or a matter of ... More


Missing Heritability: Hidden Environment in Genetic Studies of Human Behavior

Jonathan Beckwith and Corey A. Morris-Singer

in Evolution and Morality: NOMOS LII

Published in print:
2012
Published Online:
March 2016
ISBN:
9780814771228
eISBN:
9780814737828
Item type:
chapter
Publisher:
NYU Press
DOI:
10.18574/nyu/9780814771228.003.0003
Subject:
Political Science, Political Theory

This chapter explores the search for biological explanations of variation in human behavior and aptitudes, focusing on the field of human behavioral genetics. Today, the two main efforts to correlate ... More


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