Jump to ContentJump to Main Navigation

You are looking at 1-17 of 17 items

  • Keywords: translational neuroscience x
Clear All Modify Search

View:

Translational Neuroscience: Toward New Therapies

Karoly Nikolich and Steven E. Hyman (eds)

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
book
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.001.0001
Subject:
Neuroscience, Research and Theory

Translational neuroscience faces considerable challenges, as available therapies to treat brain and nervous system disorders are extremely limited and dated. Drug efficacy for depression, anxiety, ... More


Bridging the Gap between Patients and Models

Ilka Diester, Franz Hefti, Isabelle Mansuy, Alvaro Pascual-Leone, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Marius Wernig, Gül Dölen, Steven E. Hyman, Lennart Mucke, Karoly Nikolich, and Bernd Sommer

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0013
Subject:
Neuroscience, Research and Theory

Classic research into human disease tends to be top-down or bottom-up, from symptoms or genes, respectively. While bottom-up approaches may work in oncology and might advance understanding of ... More


Neurodevelopmental Disorders: What Is to Be Done?

Stephan Heckers, Steven E. Hyman, Thomas Bourgeron, Bruce N. Cuthbert, Raquel E. Gur, Cynthia Joyce, Andreas Meyer-Lindenberg, Michael J. Owen, and Matthew W. State

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0004
Subject:
Neuroscience, Research and Theory

Autism and schizophrenia are associated with abnormalities in brain development, the genetic and environmental risk factors of which are just now being discovered. How can these advances be ... More


From Rodent Behavioral Models to Human Disorders

Trevor W. Robbins

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0012
Subject:
Neuroscience, Research and Theory

To what extent is it feasible to generalize behavior in rodents to complex cognitive functions in humans via rodent models of neurodegenerative diseases or neuropsychiatric disorders? This chapter ... More


The Revolution Has Begun

Steven E. Hyman and Karoly Nikolich

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0014
Subject:
Neuroscience, Research and Theory

After decades of stagnation marked, inter alia, by all too many disappointing failures in costly, late-stage clinical trials, there is hope that new therapies for nervous system disorders are not ... More


Introduction

Karoly Nikolich and Steven E. Hyman

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0001
Subject:
Neuroscience, Research and Theory

Brain and nervous system disorders are the leading cause of disability worldwide and the primary overall cause of disease burden in established market economies. Some brain disorders are important ... More


Psychotic Disorders and the Neurodevelopmental Continuum

Michael J. Owen

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0003
Subject:
Neuroscience, Research and Theory

This chapter considers adult psychiatric disorders (schizophrenia and bipolar disorder) and childhood neurodevelopmental disorders (autism spectrum disorder and intellectual disability). The primary ... More


Pathophysiological Toolkit: Genes to Circuits

Gül Dölen, Robert C. Malenka, Joel S. Perlmutter, Nils Brose, Richard Frackowiak, Bruce N. Cuthbert, Ilka Diester, Isabelle Mansuy, Katja S. Kroker, Tobias M. Boeckers, Alvaro Pascual-Leone, and Guoping Feng

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0010
Subject:
Neuroscience, Research and Theory

Understanding the etiology and pathophysiology of neuropsychiatric disease requires the development of new tools (ranging from evolving diagnostic strategies to biomarkers) that can address the ... More


How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?

Joel S. Perlmutter

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0009
Subject:
Neuroscience, Research and Theory

How do investigators define and modulate circuits in animals that are relevant to the pathophysiology of human neurodegenerative diseases? Animal models provide a variety of advantages for ... More


What Do We Know about Early Onset Neurodevelopmental Disorders?

Thomas Bourgeron

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0002
Subject:
Neuroscience, Research and Theory

Early onset neurodevelopmental disorders include a broad range of conditions that affect brain function in children: different diagnostic categories such as fetal alcohol syndrome, ... More


How Might We Get from Genes to Circuits to Disease?

Tobias Kaiser, Yuan Mei, and Guoping Feng

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0008
Subject:
Neuroscience, Research and Theory

Recent advances in the identification of risk genes for psychiatric disorders have set the stage for functional interrogation of disease related-circuits and underlying mechanisms of pathophysiology. ... More


The Origins of Schizophrenia

Alan Brown and Paul Patterson (eds)

Published in print:
2011
Published Online:
November 2015
ISBN:
9780231151245
eISBN:
9780231521925
Item type:
book
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231151245.001.0001
Subject:
Psychology, Health Psychology

This book synthesizes key findings on a devastating mental disorder that has been increasingly studied over the past decade: namely, schizophrenia. Advances in epidemiology, translational ... More


Neurodegenerative Diseases: Where Are We Not Looking for Answers?

Walter J. Koroshetz and Lennart Mucke

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0005
Subject:
Neuroscience, Research and Theory

As life expectancy increases, burden of illness soars. The growing magnitude of the health problem and numerous failed trials of agents once considered worth investment (e.g., Alzheimer, Parkinson, ... More


Using a Stem Cell-Based Approach to Model Neurodegenerative Disease: Where Do We Stand?

Lee L. Rubin

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0011
Subject:
Neuroscience, Research and Theory

Interest in improving methods to study human disease is rapidly growing, with the goal of providing effective therapeutics for serious, complex disorders. Following the discovery of cellular ... More


Preclinical and Clinical Understanding: Major Gaps in Our Understanding and Capabilities

Edward H. Koo

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0006
Subject:
Neuroscience, Research and Theory

As life expectancy increases, age-associated diseases are an inevitable, costly burden on society. Although there are notable successes in treating some of these diseases (e.g., cerebrovascular ... More


Neurodegenerative Diseases: What Is to Be Done?

David M. Holtzman, Karoly Nikolich, Menelas N. Pangalos, Karl Broich, Nancy Y. Ip, Edward H. Koo, Walter J. Koroshetz, Eliezer Masliah, Lennart Mucke, Pierluigi Nicotera, Mareike Schnaars, and Maria Grazia Spillantini

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0007
Subject:
Neuroscience, Research and Theory

Neurodegenerative diseases lead to significant morbidity and mortality. Although medical care for other disorders (e.g., cardiovascular disease and cancer) has improved, neurodegenerative diseases ... More


RDoC’s Metaphysical Assumptions: Problems and Promises

Ginger A. Hoffman and Peter Zachar

in Extraordinary Science and Psychiatry: Responses to the Crisis in Mental Health Research

Published in print:
2017
Published Online:
September 2017
ISBN:
9780262035484
eISBN:
9780262341752
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035484.003.0004
Subject:
Psychology, Clinical Psychology

Critics contend that the categories within the DSM are fueling the current crisis in psychiatry because they are not valid. As a remedy, NIMH has established RDoC, a framework of psychological and ... More


View: