Frances Platt and Steven Walkley (eds)
- Published in print:
- 2004
- Published Online:
- September 2009
- ISBN:
- 9780198508786
- eISBN:
- 9780191723803
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198508786.001.0001
- Subject:
- Neuroscience, Disorders of the Nervous System
Lysosomal storage diseases are inherited metabolic disorders characterized by severe pathology, typically involving the brain. Although individually rare, they collectively represent a significant ...
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Lysosomal storage diseases are inherited metabolic disorders characterized by severe pathology, typically involving the brain. Although individually rare, they collectively represent a significant group of diseases that primarily present in early infancy or childhood. In recent years, considerable progress has been made in understanding the molecular mechanisms that lead to disordered function of the lysosomal system and to lysosomal storage. Unravelling the basis for these diseases is providing unique insight into the normal biology of cells and pointing the way to the development of therapeutic strategies for their treatment. This book details recent advances in the molecular and cellular pathologies of these diseases and in the development of effective therapies. After an overview of the biology of the endosomal-lysosomal system and the types of diseases resulting from defects in this system, the book describes in detail the molecular mechanisms of storage, model systems and pathophysiological mechanisms, and finally, new advances toward treatment.Less
Lysosomal storage diseases are inherited metabolic disorders characterized by severe pathology, typically involving the brain. Although individually rare, they collectively represent a significant group of diseases that primarily present in early infancy or childhood. In recent years, considerable progress has been made in understanding the molecular mechanisms that lead to disordered function of the lysosomal system and to lysosomal storage. Unravelling the basis for these diseases is providing unique insight into the normal biology of cells and pointing the way to the development of therapeutic strategies for their treatment. This book details recent advances in the molecular and cellular pathologies of these diseases and in the development of effective therapies. After an overview of the biology of the endosomal-lysosomal system and the types of diseases resulting from defects in this system, the book describes in detail the molecular mechanisms of storage, model systems and pathophysiological mechanisms, and finally, new advances toward treatment.
Thorsten Bartsch (ed.)
- Published in print:
- 2012
- Published Online:
- September 2012
- ISBN:
- 9780199592388
- eISBN:
- 9780199949922
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199592388.001.0001
- Subject:
- Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body ...
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The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical, and neurocomputational literature that presents basic mechanisms, theoretical models, and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. This book explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural, and psychiatric symptoms and surpasses the ability to encode, store, and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia.Less
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical, and neurocomputational literature that presents basic mechanisms, theoretical models, and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. This book explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural, and psychiatric symptoms and surpasses the ability to encode, store, and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia.
Sharon Lamb and Jeffrie G. Murphy (eds)
- Published in print:
- 2002
- Published Online:
- March 2012
- ISBN:
- 9780195145205
- eISBN:
- 9780199848607
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195145205.001.0001
- Subject:
- Psychology, Clinical Psychology
This book argues that forgiveness has been accepted as a therapeutic strategy without serious, critical examination. It hopes to provide a closer, critical look at some of these questions: why is ...
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This book argues that forgiveness has been accepted as a therapeutic strategy without serious, critical examination. It hopes to provide a closer, critical look at some of these questions: why is forgiveness so popular now? What exactly does it entail? When might it be appropriate for a therapist not to advise forgiveness? When is forgiveness in fact harmful? It includes many previously unpublished chapters by both philosophers and psychologists that examine what is at stake for those who are injured, those who injure them, and society in general when such a practice becomes commonplace. These chapters offer cautionary tales about forgiveness therapy, while others paint complex portraits of the social, cultural, and philosophical factors that come into play with forgiveness. The value of this volume lies not only in its presentation of a nuanced view of this therapeutic trend, but also as a general critique of psychotherapy, and as a valuable testimony of the theoretical and practical possibilities of an interdisciplinary collaboration between philosophy and clinical psychology.Less
This book argues that forgiveness has been accepted as a therapeutic strategy without serious, critical examination. It hopes to provide a closer, critical look at some of these questions: why is forgiveness so popular now? What exactly does it entail? When might it be appropriate for a therapist not to advise forgiveness? When is forgiveness in fact harmful? It includes many previously unpublished chapters by both philosophers and psychologists that examine what is at stake for those who are injured, those who injure them, and society in general when such a practice becomes commonplace. These chapters offer cautionary tales about forgiveness therapy, while others paint complex portraits of the social, cultural, and philosophical factors that come into play with forgiveness. The value of this volume lies not only in its presentation of a nuanced view of this therapeutic trend, but also as a general critique of psychotherapy, and as a valuable testimony of the theoretical and practical possibilities of an interdisciplinary collaboration between philosophy and clinical psychology.
Albrecht Ziegler
- Published in print:
- 1990
- Published Online:
- March 2012
- ISBN:
- 9780192618108
- eISBN:
- 9780191724305
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780192618108.003.0025
- Subject:
- Neuroscience, Disorders of the Nervous System
This chapter deals with problems that lie on the borderline between the pathophysiology, the pharmacotherapy, and the pharmacology of migraine. Our hopes must centre on this border, because an ...
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This chapter deals with problems that lie on the borderline between the pathophysiology, the pharmacotherapy, and the pharmacology of migraine. Our hopes must centre on this border, because an intimate and reliable knowledge of these fields will offer a clue towards an optimal therapeutic strategy. Researchers should concentrate on the drugs that have been developed as alternatives to ergotamine. It is to be hoped that these new drugs will be free of the inherent drawback of ergotamine — its deleterious side-effects when given too frequently. Satisfying results in clinical practice could render the prophylactic treatment of migraine superfluous. It could be a real advantage to avoiding prophylactic treatment, which always has to meet the high standards required of any long-term medication.Less
This chapter deals with problems that lie on the borderline between the pathophysiology, the pharmacotherapy, and the pharmacology of migraine. Our hopes must centre on this border, because an intimate and reliable knowledge of these fields will offer a clue towards an optimal therapeutic strategy. Researchers should concentrate on the drugs that have been developed as alternatives to ergotamine. It is to be hoped that these new drugs will be free of the inherent drawback of ergotamine — its deleterious side-effects when given too frequently. Satisfying results in clinical practice could render the prophylactic treatment of migraine superfluous. It could be a real advantage to avoiding prophylactic treatment, which always has to meet the high standards required of any long-term medication.
Richard P. Bentall
- Published in print:
- 2009
- Published Online:
- March 2016
- ISBN:
- 9780814791486
- eISBN:
- 9780814739143
- Item type:
- chapter
- Publisher:
- NYU Press
- DOI:
- 10.18574/nyu/9780814791486.003.0009
- Subject:
- Psychology, Developmental Psychology
This chapter discusses how for clinicians, predicting the onset of psychosis creates the possibility of developing therapeutic strategies to prevent symptoms before they occur. This idea is being ...
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This chapter discusses how for clinicians, predicting the onset of psychosis creates the possibility of developing therapeutic strategies to prevent symptoms before they occur. This idea is being pursued in some parts of the world, but presents some important ethical challenges. There is a danger that individuals at high risk will be harmed by being informed of their at-risk status, by being stigmatized as a result of being unnecessarily involved with psychiatric services, or by being coerced into receiving treatments that cause more harm than good. These risks must be taken very seriously since many people identified as being at high risk will not actually become psychotic. Any decision about the wisdom of prescribing antipsychotic medication to high-risk patients must be informed by a careful analysis of the benefits and costs of this type of treatment.Less
This chapter discusses how for clinicians, predicting the onset of psychosis creates the possibility of developing therapeutic strategies to prevent symptoms before they occur. This idea is being pursued in some parts of the world, but presents some important ethical challenges. There is a danger that individuals at high risk will be harmed by being informed of their at-risk status, by being stigmatized as a result of being unnecessarily involved with psychiatric services, or by being coerced into receiving treatments that cause more harm than good. These risks must be taken very seriously since many people identified as being at high risk will not actually become psychotic. Any decision about the wisdom of prescribing antipsychotic medication to high-risk patients must be informed by a careful analysis of the benefits and costs of this type of treatment.
