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Cannabinoids and the Brain

Linda A. Parker

Published in print:
2017
Published Online:
September 2017
ISBN:
9780262035798
eISBN:
9780262338448
Item type:
book
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035798.001.0001
Subject:
Neuroscience, Research and Theory

Cannabinoids and the Brain introduces an informed general audience to the scientific discovery of the endocannabinoid system and recent preclinical research that explains its importance in brain ... More


Is Cannabis Safe?

Leslie L. Iversen

in The Science of Marijuana

Published in print:
2007
Published Online:
January 2010
ISBN:
9780195328240
eISBN:
9780199864751
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328240.003.0006
Subject:
Neuroscience, Sensory and Motor Systems

This chapter examines the safety of cannabis. Topics discussed include toxicity, acute effects of cannabis, effects of long-term exposure to cannabis, and special hazards of smoked marijuana. It ... More


Cannabis Pharmacology

Mitch Earleywine

in Understanding Marijuana: A New Look at the Scientific Evidence

Published in print:
2003
Published Online:
April 2010
ISBN:
9780195138931
eISBN:
9780199893270
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195138931.003.0006
Subject:
Psychology, Psychopharmacology

Understanding marijuana's impact on biological systems requires a description of its active components. This chapter begins by identifying the mind-altering molecules in marijuana, the substances ... More


Prenatal Drug Exposure: Childhood Behavior and Cognitive Functioning

Thitinart Sithisarn and Henrietta S. Bada

in Cognitive and Behavioral Abnormalities of Pediatric Diseases

Published in print:
2010
Published Online:
November 2020
ISBN:
9780195342680
eISBN:
9780197562598
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195342680.003.0069
Subject:
Clinical Medicine and Allied Health, Psychiatry

Based on the estimates of the 2007 National Survey on Drug Use and Health (NSDUH), 9.5% of women of child-bearing age (ages 15–44 years)—almost six ... More


Marijuana: From Reefer Madness to THC Gummy Bears

Jerrold Winter

in Our Love Affair with Drugs: The History, the Science, the Politics

Published in print:
2020
Published Online:
November 2020
ISBN:
9780190051464
eISBN:
9780197559451
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190051464.003.0007
Subject:
Chemistry, Medicinal Chemistry

No substance better exemplifies the ambivalence of Western societies toward psychoactive drugs than marijuana. In 2017, it was estimated that there were more than 22 ... More


Known Pharmacological Actions of Delta-9-Tetrahydrocannabinol and of Four Other Chemical Constituents of Cannabis that Activate Cannabinoid Receptors

Roger G. Pertwee and Maria Grazia Cascio

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0006
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Cannabis is the source of a large set of compounds known collectively as phytocannabinoids. One of these, (−)-trans-delta-9-tetrahydrocannabinol (Δ‎9-THC), is the main psychoactive constituent of ... More


An Introduction to Cannabis

Linda A. Parker

in Cannabinoids and the Brain

Published in print:
2017
Published Online:
September 2017
ISBN:
9780262035798
eISBN:
9780262338448
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035798.003.0001
Subject:
Neuroscience, Research and Theory

Although cannabis has been used throughout human history, the scientific investigation of its effects only began with the isolation of THC in the 1960’s. Once discovered it was another 20 years ... More


Cannabis Use as a Component Cause of Schizophrenia

Paola Casadio, Marta Di Forti, and Robin M. Murray

in The Origins of Schizophrenia

Published in print:
2011
Published Online:
November 2015
ISBN:
9780231151245
eISBN:
9780231521925
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231151245.003.0006
Subject:
Psychology, Health Psychology

This chapter studies how the use of cannabis may increase the risk of schizophrenia. Cannabis use is considered as one of the component causes in the development of psychosis. Epidemiologic studies ... More


Handbook of Cannabis

Roger Pertwee (ed.)

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.001.0001
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

This book provides a multifaceted account of cannabis, a plant that is used widely both recreationally and as a medicine, as it has been over many centuries. Thus, it presents a brief account of the ... More


Effects of Phytocannabinoids on Anxiety, Mood, and the Endocrine System

Sachin Patel, Matthew N. Hill, and Cecilia J. Hillard

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0010
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Cannabis, anxiety, and depression have a close, complicated relationship. While cannabis use can be driven by its anxiolytic effects, tetrahydrocannabinol (THC) itself can induce panic and anxiety ... More


Phytocannabinoids and the Gastrointestinal System

Marnie Duncan and Angelo A. Izzo

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0012
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

The plant Cannabis, which has been traditionally employed for the treatment of gastrointestinal ailments, contains both psychotropic phytocannabinoids, such as Δ‎9-tetrahydrocannabinol and ... More


Phytocannabinoids and the Immune System

Guy A. Cabral, Erinn S. Raborn, and Gabriela A. Ferreira

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0014
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Phytocannabinoids are terpenoid-like compounds of which more than 100 have been found in the marijuana plant, Cannnabis sativa. These include Δ‎9-tetrahydrocannabinol (THC), the major psychoactive ... More


Synthetic Psychoactive Cannabinoids Licensed as Medicines

Mark A. Ware

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0021
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Since the identification and elucidation of the active principles of cannabis in 1964, the hunt for synthetic molecules that could mimic and harness the therapeutic potential of cannabinoids has been ... More


Effect of Phytocannabinoids on Nausea and Vomiting

Erin M. Rock, Martin A. Sticht, and Linda A. Parker

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0023
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Among over 60 terpeno-phenols derived from the cannabis plant, delta-9-tetrahydrocannabinol (Δ‎9-THC) has by far been the most studied for its potential to reduce nausea and vomiting. Indeed, the ... More


Established and Emerging Concepts of Cannabinoid Action on Food Intake and their Potential Application to the Treatment of Anorexia and Cachexia

Luigia Cristino and Vincenzo Di Marzo

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0024
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Appetite stimulation is one of the most often anecdotally documented actions of cannabis preparations used for recreational purposes. After the discovery of the cannabinoid CB1 and CB2 receptors for ... More


Cannabis and Epilepsy

Claire M. Williams, Nicholas A. Jones, and Benjamin J. Whalley

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0030
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Epilepsy is a progressive neurological disorder affecting approximately 1% of people whilst cannabis has a long, anecdotal history of use against seizures which has been studied clinically and ... More


Cardiovascular, Metabolic, Liver, Kidney, and Inflammatory Disorders

Pál Pacher and George Kunos

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0031
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

There is increasing evidence that phytocannabinoids may exert beneficial effects in inflammatory, cardiovascular, metabolic, liver, and kidney disorders. This chapter briefly discusses the potential ... More


The Pharmacological History of Cannabis

Ethan B. Russo

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0002
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

This chapter presents a pharmacological history of cannabis, primarily in the form of a detailed chronology highlighting key developments from various cultures around the world that employed either ... More


Effects of Phytocannabinoids on Neurotransmission in the Central and Peripheral Nervous Systems

Bela Szabo

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0008
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

There is a wealth of literature on the effects of synthetic and endogenous CB1 cannabinoid receptor agonists on neurotransmission. CB1 agonists inhibit synaptic transmission by suppressing ... More


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