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Blockbusters and Bombs: Pressures on the Pharmaceutical Industry

Michael Kinch

in Prescription for Change: The Looming Crisis in Drug Development

Published in print:
2016
Published Online:
May 2017
ISBN:
9781469630625
eISBN:
9781469630649
Item type:
chapter
Publisher:
University of North Carolina Press
DOI:
10.5149/northcarolina/9781469630625.003.0008
Subject:
Business and Management, Innovation

The first indications of future trouble are identified. For most of history, new medicines arise from nature but this approach came into question as evidenced by the development of the cancer drug ... More


How the Government Created the Pharmaceutical Industry

Robert I. Field

in Mother of Invention: How the Government Created "Free-Market" Health Care

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199746750
eISBN:
9780199354528
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199746750.003.0003
Subject:
Public Health and Epidemiology, Public Health

The pharmaceutical industry, perennially one of the most profitable,requires a steady flow of biomedical research to develop new products. However, investment in basic scienceis difficult for private ... More


From Molecules to Medicines: The Use of Genetic Resources in Pharmaceutical Research

Astrid J. Scholz

in Engineering Trouble: Biotechnology and Its Discontents

Published in print:
2003
Published Online:
March 2012
ISBN:
9780520237612
eISBN:
9780520937499
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520237612.003.0009
Subject:
History, History of Science, Technology, and Medicine

This chapter describes the drug discovery process in pharmaceutical research to show how deeply the new biotechnologies constitute the politics and economics of genetic resources. The analysis ... More


Trade Secrets Fraud and Economic Espionage

Roger W. Shuy

in The Language of Fraud Cases

Published in print:
2016
Published Online:
December 2015
ISBN:
9780190270643
eISBN:
9780190270667
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780190270643.003.0005
Subject:
Linguistics, Sociolinguistics / Anthropological Linguistics

The Uniform Trade Secrets Act protects the intellectual property of industries from theft of trade secrets. In 1995 a government agent publicly advertised his services as a technology information ... More


Success and Remorse

in Science for Sale: The Perils, Rewards, and Delusions of Campus Capitalism

Published in print:
2007
Published Online:
March 2013
ISBN:
9780226306254
eISBN:
9780226306261
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226306261.003.0009
Subject:
Society and Culture, Ethical Issues and Debates

This chapter discusses the experience of Robert Holton with the development of Taxol, a widely used and famously profitable drug for the treatment of breast and ovarian cancer in the 1980s. Though ... More


Hallelujah Moments: Tales of Drug Discovery

Eugene H. Cordes

Published in print:
2020
Published Online:
May 2021
ISBN:
9780190080457
eISBN:
9780190080488
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190080457.001.0001
Subject:
Chemistry, Medicinal Chemistry

This work provides eleven stories of drug discovery and features the scientists who made them. The outcome of the discovery work has provided novel therapies in cancer, cardiovascular medicine, ... More


Product Development to Business

James Wei

in Product Engineering: Molecular Structure and Properties

Published in print:
2007
Published Online:
November 2020
ISBN:
9780195159172
eISBN:
9780197561997
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195159172.003.0006
Subject:
Chemistry, Physical Chemistry

Many historians and journalists conclude an exciting story of innovation at the discovery phase, when there emerges a plausible idea of a new product. However, for most innovative products, the ... More


Paclitaxel (Taxol)

Jie Jack Li

in Top Drugs: Their History, Pharmacology, and Syntheses

Published in print:
2015
Published Online:
November 2020
ISBN:
9780199362585
eISBN:
9780197562918
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199362585.003.0009
Subject:
Chemistry, Medicinal Chemistry

Cancer is a disease of cellular dysfunction involving a range of biological activities that promote unregulated proliferation. It is as old as the existence of animals— cancers are found even in ... More


Seduced by drug discovery

Eugene H. Cordes

in Hallelujah Moments: Tales of Drug Discovery

Published in print:
2020
Published Online:
May 2021
ISBN:
9780190080457
eISBN:
9780190080488
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190080457.003.0001
Subject:
Chemistry, Medicinal Chemistry

The opportunity to see the fruit of scientific work in one’s own lifetime proved a compelling motivation to leave a productive academic career in biochemistry and join the pharmaceutical industry, ... More


The discovery of taxol: Wall, Horwitz, Holton

Eugene H. Cordes

in Hallelujah Moments: Tales of Drug Discovery

Published in print:
2020
Published Online:
May 2021
ISBN:
9780190080457
eISBN:
9780190080488
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190080457.003.0007
Subject:
Chemistry, Medicinal Chemistry

Taxol is a widely employed drug for chemotherapy of breast cancer and finds use for ovarian and lung cancer as well as for Kaposi’s syndrome. Getting from the discovery of taxol to approval for ... More


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