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Synaptic Function

Kullmann Dimitri

in The Hippocampus Book

Published in print:
2006
Published Online:
May 2009
ISBN:
9780195100273
eISBN:
9780199864133
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195100273.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience

This chapter considers how the release of glutamate from presynaptic terminals in the hippocampus and its action on various glutamatergic receptors mediate excitatory synaptic transmission. It ... More


Glia and Synaptic Transmission

Eric A. Newman

in Neuroglia

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.003.0028
Subject:
Neuroscience, Development, Disorders of the Nervous System

This chapter reviews recent evidence defining glial-neuronal interactions at the tripartite synapse. Topics covered include structure of the tripartite synapse, neuronal activation of glial cells, ... More


Excitatory Amino Acid Transmission and Synaptic Plasticity

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0011
Subject:
Neuroscience, Sensory and Motor Systems

Activity-dependent, long-lasting synaptic enhancement induced by neuronal stimulation, known as long-term potentiation (LTP), is not unique to the hippocampus; rather, it seems to be a fundamental ... More


Neurobiology Of Chronic Pain

Min Zhuo

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems

Understanding the neurobiology of sensory synapses in the central nervous system provides us with basic knowledge of physiological and pathological pain, and has the potential to reveal possible drug ... More


NMDA receptors and their interactions with other excitatory amino acid receptors in synaptic transmission in the mammalian central nervous system

T. E. SALT

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter seeks to review some of the electrophysiological work which has been carried out using excitatory amino acid antagonists. A selection of studies of brain areas has been chosen for review ... More


The NMDA Receptor

G. L. Collingridge and J. C. Watkins (eds)

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems

This book comprises coverage of the NMDA receptor. The NMDA receptor is an important protein in the brain, which is involved in physiological processes such as synaptic transmission and synaptic ... More


Functional plasticity at synapses

Motoy Kuno

in The Synapse: Function, Plasticity, and Neurotrophism

Published in print:
1994
Published Online:
March 2012
ISBN:
9780198546870
eISBN:
9780191724350
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198546870.003.0091
Subject:
Neuroscience, Molecular and Cellular Systems

Functional synaptic plasticity is a relatively longlasting alteration in the efficiency of synaptic transmission. In biophysical terms, the efficiency of synaptic transmission is determined by two ... More


Molecular biology of postsynaptic structures

Flaminio Cattabeni, Fabrizio Gardoni, and Monica Di Luca

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems

The neurotransmitter glutamate mediates the majority of excitatory synaptic transmission in the brain. Excitatory glutamatergic synapses feature a prominent thickening at the cytoplasmic surface of ... More


Neurons and Simple Memory Circuits

Howard Eichenbaum

in The Cognitive Neuroscience of Memory: An Introduction

Published in print:
2002
Published Online:
May 2009
ISBN:
9780195141740
eISBN:
9780199865741
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141740.003.0002
Subject:
Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems

This chapter summarizes some of the key fundamental concepts about the anatomy and physiology of neurons, including the molecular basis of the unusual electrical properties of neurons, different ... More


NMDA receptors and long-term potentiation in the hippocampus

ZAFAR I. BASHIR, NICOLA BERRETTA, ZUNER A. BORTOLOTTO, KATH CLARK, CERI H. DAVIES, BRUNO G. FRENGUELLI, JENNI HARVEY, BRIGITTE POTIER, and GRAHAM L. COLLINGRIDGE

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0013
Subject:
Neuroscience, Molecular and Cellular Systems

N-methyl-d-aspartate (NMDA) receptors have been shown to have two important physiological roles in the vertebrate central nervous system; they are mediators of synaptic ... More


Nmda Receptors

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0005
Subject:
Neuroscience, Sensory and Motor Systems

Ionotropic glutamate receptors, including NMDA receptors, mediate most of the excitatory synaptic transmission in the mammalian central nervous system. When NMDA receptors are activated by membrane ... More


Glutamate and Glutamate Receptors in Neurological Diseases

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0012
Subject:
Neuroscience, Sensory and Motor Systems

Although glutamate (Glu) normally functions as a neurotransmitter, excess Glu can be harmful and can cause cells to degenerate. Glutamate can cause neuronal cell death by a mechanism referred to as ... More


Modeling Synapses

Arnd Roth and Mark C. W. van Rossum

in Computational Modeling Methods for Neuroscientists

Published in print:
2009
Published Online:
August 2013
ISBN:
9780262013277
eISBN:
9780262258722
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262013277.003.0007
Subject:
Neuroscience, Techniques

This chapter discusses the models at different levels of realism and computational efficiency for simulating synapses and their plasticity. It outlines the experimental data that offer the parameter ... More


Synaptic transmission in the squid stellate ganglion

R. Llinás and M. Sugimori

in Cephalopod Neurobiology: Neuroscience Studies in Squid, Octopus and Cuttlefish

Published in print:
1995
Published Online:
March 2012
ISBN:
9780198547907
eISBN:
9780191724299
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198547907.003.0173
Subject:
Neuroscience, Invertebrate Neurobiology

Synaptic transmission in the squid stellate ganglion is studied in this chapter. The giant synapse is the last junction in a three-link chain of giant neurons that form the escape system in squid. ... More


Excitatory Amino Acid Transmission in Health and Disease

Robert Balazs, Richard J. Bridges, and Carl W. Cotman

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.001.0001
Subject:
Neuroscience, Sensory and Motor Systems

This book provides a comprehensive, easy-to-read survey of excitatory amino acids and synaptic transmission. It begins with descriptions of the structure, function, and pharmacology of both the ... More


Kainate Receptors

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0004
Subject:
Neuroscience, Sensory and Motor Systems

Both kainate receptors and AMPA receptors mediate fast excitatory synaptic transmission and are associated primarily with voltage-independent channels that gate a depolarizing current mainly carried ... More


Cortical Synaptic Transmission: An Overview

Charles F. Stevens

in The Cortical Neuron

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195083309
eISBN:
9780199847464
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195083309.003.0002
Subject:
Neuroscience, Molecular and Cellular Systems

A microliter of brain contains approximately a billion synapses, about two-thirds of which are excitatory. Clearly synapses are vital because the brain uses so many of them, but their close packing ... More


Effects of Phytocannabinoids on Neurotransmission in the Central and Peripheral Nervous Systems

Bela Szabo

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0008
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

There is a wealth of literature on the effects of synthetic and endogenous CB1 cannabinoid receptor agonists on neurotransmission. CB1 agonists inhibit synaptic transmission by suppressing ... More


Neuroglia

Helmut Kettenmann and Bruce R. Ransom (eds)

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.001.0001
Subject:
Neuroscience, Development, Disorders of the Nervous System

This book details the basic biology and function of glial cells. It covers the entire field of glial research from the basic molecular and cellular properties of these cells to their involvement in ... More


Activation of NMDA receptors

A. J. GIBB, B. EDMONDS, R. A. SILVER, S. G. CULL-CANDY, and D. COLQUHOUN

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0009
Subject:
Neuroscience, Molecular and Cellular Systems

Understanding the processes occurring during receptor activation is of fundamental importance to pharmacology, and activation of receptors such as the NMDA receptor, which have an integral membrane ... More


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