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Design and analysis issues in genome-wide association studies

Duncan C. Thomas

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0008
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The recent availability of commercial high-density genotyping technologies, combined with the identification of subsets of single nucleotide polymorphisms (SNPs) that are capable of “tagging” most of ... More


Micro-Econometrics for Policy, Program and Treatment Effects

Myoung-jae Lee

Published in print:
2005
Published Online:
February 2006
ISBN:
9780199267699
eISBN:
9780191603044
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/0199267693.001.0001
Subject:
Economics and Finance, Econometrics

This book brings to the fore recent advances in econometrics for treatment effect analysis. It aims to put together various economic treatment effect models in a coherent fashion, determine those ... More


Study designs

James R. Borchers and Thomas Best

in Sports Injury Research

Published in print:
2009
Published Online:
February 2010
ISBN:
9780199561629
eISBN:
9780191722479
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199561629.003.02
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Within epidemiological research there are a number of study designs that can be used to answer the research question. All of these designs have pros and cons, as well as do's and don'ts. This chapter ... More


Historical Research

Elizabeth Ann Danto

Published in print:
2008
Published Online:
January 2009
ISBN:
9780195333060
eISBN:
9780199864119
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195333060.001.0001
Subject:
Social Work, Research and Evaluation

What, exactly, was the Charity Organization Society? Was it a cluster of affluent women imposing their moral propriety on the poor in the early 20th century? Or was it the first concerted effort to ... More


Epidemiological study design and principles of data analysis: An integrated suite of methods

Raj S. Bhopal

in Concepts of Epidemiology: Integrating the ideas, theories, principles and methods of epidemiology

Published in print:
2008
Published Online:
September 2009
ISBN:
9780199543144
eISBN:
9780191723995
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199543144.003.0009
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Epidemiological studies have apparently distinct designs but are unified by their common goal to understand the frequency and causes of disease, by their strategy of seeking associations between ... More


Study Designs

Ezra Susser, Sharon Schwartz, Alfredo Morabia, and Evelyn J. Bromet

in Psychiatric Epidemiology: Searching for the Causes of Mental Disorders

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195101812
eISBN:
9780199864096
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195101812.003.06
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter describes different risk factor study designs. Study designs can be viewed as techniques for organizing observations in ways that can reveal the causes of disease. The risk factor study ... More


Design Concepts in Nutritional Epidemiology

Barrie M. Margetts and Michael Nelson (eds)

Published in print:
1997
Published Online:
September 2009
ISBN:
9780192627391
eISBN:
9780191723704
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192627391.001.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This book provides a practical guide to the understanding, interpretation, and application of the principles of nutritional epidemiology, set in the context of public health nutrition. Relating ... More


Social and Sexual Networks: The National Longitudinal Study of Adolescent Health

Martina Morris

in Network Epidemiology: A Handbook for Survey Design and Data Collection

Published in print:
2004
Published Online:
August 2004
ISBN:
9780199269013
eISBN:
9780191601330
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/0199269017.003.0010
Subject:
Economics and Finance, Development, Growth, and Environmental

This chapter describes the design and structure of the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative sample of over 90,000 adolescents attending school in ... More


Experimental and quasi-experimental designs

Massimo Costantini and Irene J. Higginson

in Research Methods in Palliative Care

Published in print:
2007
Published Online:
November 2011
ISBN:
9780198530251
eISBN:
9780191729980
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198530251.003.0006
Subject:
Palliative Care, Palliative Medicine Research, Patient Care and End-of-Life Decision Making

This chapter discusses the probable use of experimental and quasi-experimental research designs in palliative care. In order to describe the most common non-experimental study designs that are used ... More


One Design for Narrative Study

Kathleen Wells

in Narrative Inquiry

Published in print:
2011
Published Online:
January 2011
ISBN:
9780195385793
eISBN:
9780199827237
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195385793.003.0002
Subject:
Social Work, Research and Evaluation

This chapter considers narrative inquiry in relation to the case study design, identifying its purposes, defining features, and significance. It considers ways in which to define a case and to select ... More


Association studies

Emily Webb and Richard Houlston

in Statistics and Informatics in Molecular Cancer Research

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199532872
eISBN:
9780191714467
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199532872.003.0001
Subject:
Mathematics, Probability / Statistics, Biostatistics

Association studies provide a highly efficient paradigm for identifying novel genetic loci that influence the risk of disease, and recent technological advances have led to the discovery via ... More


Network Dynamism: History and Lessons of the Colorado Springs Study

Martina Morris

in Network Epidemiology: A Handbook for Survey Design and Data Collection

Published in print:
2004
Published Online:
August 2004
ISBN:
9780199269013
eISBN:
9780191601330
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/0199269017.003.0006
Subject:
Economics and Finance, Development, Growth, and Environmental

This chapter describes the pioneering longitudinal partial network data collected by the Colorado Springs research team in 1990-95 to assess HIV and STD transmission potential in the region. The ... More


The Urban and Rural Networks Project: Atlanta and Flagstaff

Martina Morris

in Network Epidemiology: A Handbook for Survey Design and Data Collection

Published in print:
2004
Published Online:
August 2004
ISBN:
9780199269013
eISBN:
9780191601330
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/0199269017.003.0007
Subject:
Economics and Finance, Development, Growth, and Environmental

This chapter describes the partial network data collected by two studies of partnership networks conducted in Atlanta and Flagstaff in the early 1990s to compare the HIV and STD risk networks. The ... More


Overview of Study Designs

Harvey Checkoway, Neil Pearce, and David Kriebel

in Research Methods in Occupational Epidemiology

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195092424
eISBN:
9780199864553
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195092424.003.0003
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The choice of epidemiologic study design is largely dictated by the health outcomes of primary interest, feasibility, and availability of valid exposure data. This chapter provides brief descriptions ... More


The Thailand and Ugandan Sexual Network Studies

Martina Morris

in Network Epidemiology: A Handbook for Survey Design and Data Collection

Published in print:
2004
Published Online:
August 2004
ISBN:
9780199269013
eISBN:
9780191601330
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/0199269017.003.0004
Subject:
Economics and Finance, Development, Growth, and Environmental

This chapter describes the comparative local network data collected in two related studies of HIV-related behaviors in Uganda and Thailand in the mid-1990s. The Thai survey was based on a cluster ... More


Sexual Networks and HIV in Four African Populations: The Use of Standardized Behavioral Survey with Biological Markers

Martina Morris

in Network Epidemiology: A Handbook for Survey Design and Data Collection

Published in print:
2004
Published Online:
August 2004
ISBN:
9780199269013
eISBN:
9780191601330
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/0199269017.003.0005
Subject:
Economics and Finance, Development, Growth, and Environmental

This chapter describes the local network data collected in four African towns in the late 1990s to ascertain the determinants of the large observed HIV prevalence differentials. The design used a ... More


Overview of Study Designs

Thomas D. Koepsell and Noel S. Weiss

in Epidemiologic Methods: Studying the Occurrence of Illness

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195150780
eISBN:
9780199865161
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150780.003.0005
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

A study design is a plan for selecting study subjects and for obtaining data about them. Study subjects in epidemiology are typically individual people, but at times they can be other kinds of ... More


2. Design, planning, and evaluation of nutritional epidemiological studies

Michael Nelson and Barrie M. Margetts

in Design Concepts in Nutritional Epidemiology

Published in print:
1997
Published Online:
September 2009
ISBN:
9780192627391
eISBN:
9780191723704
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192627391.003.0002
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter outlines the key stages in the design and interpretation of nutritional epidemiological studies; considers the pitfalls likely to be met; reviews the ways in which new techniques may be ... More


Cross-sectional and Repeated Measures Studies

Harvey Checkoway, Neil Pearce, and David Kriebel

in Research Methods in Occupational Epidemiology

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195092424
eISBN:
9780199864553
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195092424.003.0007
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Cross-sectional studies are particularly well suited for investigating workplace hazards in relation to non-fatal health outcomes, such as disease symptoms. The repeated measures design is an ... More


Choosing Cases in Biologic Psychiatry

Ezra Susser, Sharon Schwartz, Alfredo Morabia, and Evelyn J. Bromet

in Psychiatric Epidemiology: Searching for the Causes of Mental Disorders

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195101812
eISBN:
9780199864096
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195101812.003.20
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The previous chapter proposed that biologic studies comparing cases with controls often correspond well to the case-control design. This chapter shows how this perspective can be useful for advancing ... More


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