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Macromolecular Crystallization and Crystal Perfection

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199213252
eISBN:
9780191707575
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213252.001.0001
Subject:
Physics, Crystallography: Physics

Structural crystallography provides key information to understand the mechanism involved for biological processes. The technique requires high‐quality crystals. The book Macromolecular ... More


Molecular replacement techniques for high-throughput structure determination

Marc Delarue

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0007
Subject:
Biology, Biochemistry / Molecular Biology

In the context of structural genomics projects, there are two main routes to consider for solving efficiently and rapidly the three-dimensional (3D) structure of the target gene products by ... More


Getting a macromolecular model: model building, refinement, and validation

R. J. Morris, A. Perrakis, and V. S. Lamzin

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0011
Subject:
Biology, Biochemistry / Molecular Biology

This chapter casts the high-throughput automation efforts being developed to meet the needs of Structural Genomics initiatives in the framework of an optimization problem. It gives a general overview ... More


Screening

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

in Macromolecular Crystallization and Crystal Perfection

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199213252
eISBN:
9780191707575
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213252.003.0004
Subject:
Physics, Crystallography: Physics

Finding initial crystallization conditions for a new macromolecule can be like searching for a needle in a haystack. The first step is to set up screening trials, exposing the macromolecule to ... More


MAD phasing

H. M. Krishna Murthy

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0008
Subject:
Biology, Biochemistry / Molecular Biology

From a relatively small beginning, nearly two decades ago, phase calculation using multiple-wavelength anomalous diffraction (MAD) data has become more widespread and generally used. This chapter ... More


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