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Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Stephen M. Evans, Ann Marie Janson, and Jens Randel Nyengaard (eds)

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.001.0001
Subject:
Neuroscience, Techniques

Stereology is a valuable tool for neuroscientists, allowing them to obtain three-dimensional information from two-dimensional measurements made on appropriately sampled sections (usually obtained ... More


Stereology

Werner Nagel

in New Perspectives in Stochastic Geometry

Published in print:
2009
Published Online:
February 2010
ISBN:
9780199232574
eISBN:
9780191716393
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199232574.003.0014
Subject:
Mathematics, Geometry / Topology

In the present chapter some essential mathematical principles of stereology are presented. Considering that several excellent new books and surveys appeared over the past years, it is not aimed to ... More


Estimation of number and volume of immunohistochemically stained neurons in complex brain regions

Karl-Anton Dorph-Petersen, Raben Rosenberg, and Jens R. Nyengaard

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0010
Subject:
Neuroscience, Techniques

One of the most important methods for studying the central nervous system is by microscopy of histological slides. Advanced histological techniques have put increasing demands upon the tissue ... More


Unbiased morphometrical techniques for the quantitative assessment of cells in primary dissociation cultures

H Schröder, J. R. Nyengaard, W Selberis, E Lain, A Keller, C Köhler, and B Witter

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0015
Subject:
Neuroscience, Techniques

This chapter presents a neuroscientific study using a primary neuronal dissociation culture in which it was necessary to obtain reliable data as to whether the induction of potentially toxic ... More


General introduction

Stephen M. Evans and Jens R. Nyengaard

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0001
Subject:
Neuroscience, Techniques

This chapter begins with a brief discussion of the use of stereology in neuroscience. It then discusses image analysis and computer-assisted devices, the advent of modern stereology, sampling ... More


A case study from neuroscience involving stereology and multivariate analysis

Luis M. Cruz-Orive, Ana M. Insausti, Ricardo Insausti, and Dámaso Crespo

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0002
Subject:
Neuroscience, Techniques

Downs syndrome is characterized by a triplication of chromosome 21 (HSA-21), and is the most frequent cause of mental retardation in the newborn. A special trisomic mouse (Ts65Dn) is a well known ... More


Section introduction

Stephen M. Evans and Jens R. Nyengaard

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0003
Subject:
Neuroscience, Techniques

Most neuroscientists would accept that neurons and synapses form the fundamental building blocks for information processing in the central nervous system. Although this is a somewhat simplified view, ... More


Counting in situ hybridized neurons

Bente Finsen, Rikke Gregersen, Elin Lehrmann, Steen Lovmand, and Mark J. West

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0005
Subject:
Neuroscience, Techniques

This chapter discusses in situ hybridization. Topics covered include the principles of hybridization, visualization of single cells with AP-conjugated oligonucleotide probes, sensitivity of alkaline ... More


Number in electron microscopy: estimation of total number of synapses in the main regions of human neocortex

Jens R. Nyengaard, Karl-Anton Dorph-Petersen, and Yong Tang

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0006
Subject:
Neuroscience, Techniques

Significant disagreements exist among previous morphometric studies of synapse number in relation to memory deficits associated with aging and diseases such as Alzheimer's disease. There may be a ... More


The number of microvessels estimated by an unbiased stereological method applied in a brain region

Annemette Løkkegaard

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0007
Subject:
Neuroscience, Techniques

The microvascular network provides the means by which tissues exchange nutrients and are supplied with oxygen. The microvascular network is crucial for the function of tissues and organs, and the ... More


Section introduction

Jens R. Nyengaard and Stephen M. Evans

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0008
Subject:
Neuroscience, Techniques

Information concerning the size of a brain structure and how this changes with normal development and disease provides vital information on the function of the structure. Modern stereology offers a ... More


The nucleator and the planar and optical rotators applied in rat dorsal root ganglia

Trine Tandrup

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0009
Subject:
Neuroscience, Techniques

The correct parameter for describing size of a neuron perikaryon is a volume or a surface estimate. To obtain unbiased estimates of these three-dimensional parameters careful considerations about ... More


Brain Soup

Suzana Herculano-Houzel

in The Human Advantage: A New Understanding of How Our Brain Became Remarkable

Published in print:
2016
Published Online:
September 2016
ISBN:
9780262034258
eISBN:
9780262333214
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262034258.003.0002
Subject:
Neuroscience, Behavioral Neuroscience

Why two brains of similar size probably don’t have similar numbers of neurons; 100 billion neurons in the human brain as an order-of-magnitude estimate; how to count cells in a brain; how to turn ... More


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