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Traumatic injury of spinal axons

OSAMU HONMOU and WISE YOUNG

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0025
Subject:
Neuroscience, Disorders of the Nervous System

This chapter discusses the mechanisms of axonal loss and dysfunction in spinal cord injury. It focuses on the primary causes of axonal injury, the subsequent extracellular ionic derangements that ... More


Summary of Strategies Used to Repair the Injured Spinal Cord

Gerta Vrbová and Urszula Sławin´ska

in Restorative Neurology of Spinal Cord Injury

Published in print:
2011
Published Online:
January 2012
ISBN:
9780199746507
eISBN:
9780199918768
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199746507.003.0005
Subject:
Neuroscience, Sensory and Motor Systems, Disorders of the Nervous System

At the Summer School for Biological Treatment of Chronic Spinal Cord Injury, held in Vienna in October 2008, some approaches tested on patients, based on experimental work on animals to encourage ... More


Clinical aspects of traumatic injury to central nervous system axons

MILAN R. DIMITRIJEVIC

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0034
Subject:
Neuroscience, Disorders of the Nervous System

This chapter begins by describing the features of segmental reflex activities in patients with chronic and clinically complete spinal cord injury. It then presents evidence that some of those ... More


Therapy of acute spinal cord injury

Wise Young

in Spinal Cord Dysfunction: Volume II: Intervention and Treatment

Published in print:
1991
Published Online:
March 2012
ISBN:
9780192617873
eISBN:
9780191724312
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192617873.003.0003
Subject:
Neuroscience, Disorders of the Nervous System

Clinical and laboratory approaches to spinal cord injury maintain the traditional pessimism first expressed in the Edwin Smith Papyrus, which regarded the possibility of recovery from spinal cord ... More


Neural Control of Locomotion

Gerta Vrbová, Urszula Sławin´ska, and Henryk Majczyn´ski

in Restorative Neurology of Spinal Cord Injury

Published in print:
2011
Published Online:
January 2012
ISBN:
9780199746507
eISBN:
9780199918768
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199746507.003.0004
Subject:
Neuroscience, Sensory and Motor Systems, Disorders of the Nervous System

This chapter presents animal models of spinal cord injury (SCI) and discusses how an understanding of the mechanisms responsible for producing the locomotor pattern, rhythmic limb movements ... More


Human Neural Stem Cell–Mediated Repair of the Contused Spinal Cord: Timing the Microenvironment

Brian J. Cummings, Mitra J. Hooshmand, Desirée L. Salazar, and Aileen J. Anderson

in From Development to Degeneration and Regeneration of the Nervous System

Published in print:
2008
Published Online:
May 2009
ISBN:
9780195369007
eISBN:
9780199865253
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195369007.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems, Development

Spinal cord injury (SCI) is a debilitating and devastating condition that affects approximately 11,000 new people in the United States each year. Understanding of the pathophysiology and potential ... More


Brain and Spinal Cord Injury

Lorene M. Nelson, Caroline M. Tanner, Stephen K. Van Den Eeden, and Valerie M. McGuire

in Neuroepidemiology: From principles to practice

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195133790
eISBN:
9780199863730
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195133790.003.10
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Up to 50% of all trauma deaths in the United States involve significant injury to the brain or spinal cord. This chapter highlights the public health significance of traumatic brain and spinal cord ... More


Epilogue

Milan R Dimitrijevic, Byron A Kakulas, W. Barry McKay, and Gerta Vrbová

in Restorative Neurology of Spinal Cord Injury

Published in print:
2011
Published Online:
January 2012
ISBN:
9780199746507
eISBN:
9780199918768
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199746507.003.0011
Subject:
Neuroscience, Sensory and Motor Systems, Disorders of the Nervous System

This chapter evaluates the significance of considering residual neural function at the subclinical level in clinical practice to enhance the control of movement after spinal cord injury. Existing ... More


Criteria for Biological Interventions for Spinal Cord Injury Repair

Keith Tansey and Byron A Kakulas

in Restorative Neurology of Spinal Cord Injury

Published in print:
2011
Published Online:
January 2012
ISBN:
9780199746507
eISBN:
9780199918768
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199746507.003.0007
Subject:
Neuroscience, Sensory and Motor Systems, Disorders of the Nervous System

This chapter reviews the pathophysiological status of the spinal cord after injury and establishes criteria for biological intervention. It details the pathological cascade that occurs during the ... More


Evidence-Based Practice and Activity-Based Therapy for Recovery of Posture, Standing, and Walking

Susan J. Harkema, Andrea L. Behrman, and Hugues Barbeau

in Locomotor Training: Principles and Practice

Published in print:
2011
Published Online:
September 2011
ISBN:
9780195342086
eISBN:
9780199897063
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195342086.003.0001
Subject:
Neuroscience, Sensory and Motor Systems, Techniques

This chapter reviews physical rehabilitation for posture, standing, and walking from an historical perspective, and provides a context for the emergence of locomotor training as an activity-based ... More


Pain in spinal cord injury

Aleksandar Berić

in Spinal Cord Dysfunction: Volume II: Intervention and Treatment

Published in print:
1991
Published Online:
March 2012
ISBN:
9780192617873
eISBN:
9780191724312
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192617873.003.0011
Subject:
Neuroscience, Disorders of the Nervous System

Sustaining a spinal cord injury (SCI), even a severe one, does not necessarily entail pain, although the majority of SCI patients in the acute phase do experience pain, which usually subsides with ... More


Suppression of Nogo-A to Enhance CNS Repair

Willi Roman and Schwab Martin E.

in Cerebral Plasticity: New Perspectives

Published in print:
2011
Published Online:
August 2013
ISBN:
9780262015233
eISBN:
9780262295444
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262015233.003.0029
Subject:
Neuroscience, Research and Theory

This chapter concentrates on the characteristics of Nogo-A and its signaling pathway components in neurite growth inhibition and describes mechanisms of central nervous system (CNS) repair after ... More


Cyberanatomies of Hope

Priscilla Song

in Biomedical Odysseys: Fetal Cell Experiments from Cyberspace to China

Published in print:
2017
Published Online:
May 2018
ISBN:
9780691174778
eISBN:
9781400885282
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691174778.003.0004
Subject:
Anthropology, Social and Cultural Anthropology

This chapter explores how the embodied dynamics of illness and chronicity shape online modes of health-seeking by comparing the experiences of people living with spinal cord injuries (SCIs) to those ... More


A Clinical Trial for Paralysis Treatment

Sheldon Krimsky

in Stem Cell Dialogues: A Philosophical and Scientific Inquiry Into Medical Frontiers

Published in print:
2015
Published Online:
November 2015
ISBN:
9780231167482
eISBN:
9780231539401
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231167482.003.0025
Subject:
Biology, Bioethics

This dialogue is a fictional account of science reporter Valerie Legere's interview with Dr. Fred Lincoln, a medical doctor working for Geron Corporation of Menlo Park, California. Geron was the ... More


Mobilizing the Paralyzed Online

Priscilla Song

in Biomedical Odysseys: Fetal Cell Experiments from Cyberspace to China

Published in print:
2017
Published Online:
May 2018
ISBN:
9780691174778
eISBN:
9781400885282
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691174778.003.0003
Subject:
Anthropology, Social and Cultural Anthropology

This chapter traces the spatial and temporal dynamics of CareCure—an online discussion forum devoted to research and treatment for spinal cord injury (SCI). Created from a U.S. neuroscientist's ... More


Hope

Sheldon Krimsky

in Stem Cell Dialogues: A Philosophical and Scientific Inquiry Into Medical Frontiers

Published in print:
2015
Published Online:
November 2015
ISBN:
9780231167482
eISBN:
9780231539401
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231167482.003.0001
Subject:
Biology, Bioethics

In this dialogue, Samuel Franklin, a sixty-six-year-old retired contractor suffering from thoracic spinal cord injury, and his daughter Rebecca are having a conversation about the promise of stem ... More


Competitive NMDA antagonists as drugs

B. S. MELDRUM and A. G. CHAPMAN

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0019
Subject:
Neuroscience, Molecular and Cellular Systems

The potential clinical applications of N-methyl-d-aspartate (NMDA) antagonists were initially defined on the basis of animal models. Epilepsy was the first target syndrome identified and remains an ... More


Secrets and Magic Pills: Constructing Masculinity and Sexual “Normalcy” Following Spinal Cord Injury

Alexis A. Bender

in Sex for Life: From Virginity to Viagra, How Sexuality Changes Throughout Our Lives

Published in print:
2012
Published Online:
March 2016
ISBN:
9780814772522
eISBN:
9780814723814
Item type:
chapter
Publisher:
NYU Press
DOI:
10.18574/nyu/9780814772522.003.0010
Subject:
Sociology, Marriage and the Family

This chapter focuses on how men reconstruct masculinity and sexual “normalcy” following spinal cord injuries. There are at least four paths for men's sexual trajectories following spinal cord injury ... More


Where the Virtual Becomes Visceral

Priscilla Song

in Biomedical Odysseys: Fetal Cell Experiments from Cyberspace to China

Published in print:
2017
Published Online:
May 2018
ISBN:
9780691174778
eISBN:
9781400885282
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691174778.003.0005
Subject:
Anthropology, Social and Cultural Anthropology

This chapter follows the journey of people living with paralysis and neurodegenerative conditions as they undergo fetal cell transplantation in China. It provides ethnographic insight on how these ... More


Regenerating the Brain

Walter Glannon

in Brain, Body, and Mind: Neuroethics with a Human Face

Published in print:
2011
Published Online:
May 2011
ISBN:
9780199734092
eISBN:
9780199894475
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199734092.003.0017
Subject:
Philosophy, Moral Philosophy

This chapter examines neural cell replacement therapy for neurodegenerative diseases and spinal cord injury. While neural transplantation has the potential to regenerate the brain, results from ... More


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