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Introduction

Joachim Frank

in Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State

Published in print:
2006
Published Online:
April 2010
ISBN:
9780195182187
eISBN:
9780199893416
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195182187.003.0001
Subject:
Biology, Biochemistry / Molecular Biology

This introductory chapter begins with an appreciation of the unique position of electron microscopy in biological research as it bridges a wide gap between X-ray crystallography and light microscopy. ... More


Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State

Joachim Frank

Published in print:
2006
Published Online:
April 2010
ISBN:
9780195182187
eISBN:
9780199893416
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195182187.001.0001
Subject:
Biology, Biochemistry / Molecular Biology

In this book, the mathematical principles and working methods of single-particle reconstruction are described; a method designed to retrieve three-dimensional structural information from electron ... More


Electron Microscopy in Three Dimensions

Peter B. Moore

in Visualizing the Invisible: Imaging Techniques for the Structural Biologist

Published in print:
2012
Published Online:
May 2015
ISBN:
9780199767090
eISBN:
9780190267841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:osobl/9780199767090.003.0013
Subject:
Biology, Biochemistry / Molecular Biology

This chapter emphasizes that the ultimate goal of structural biology is to define the three-dimensional structure of biological specimens at atomic resolutions. To meet this goal, three-dimensional ... More


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