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Cell Signaling: The cell as electronic computer

Andrew S. Reynolds

in The Third Lens: Metaphor and the Creation of Modern Cell Biology

Published in print:
2018
Published Online:
January 2019
ISBN:
9780226563121
eISBN:
9780226563435
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226563435.003.0005
Subject:
Philosophy, Philosophy of Science

This chapter deals with metaphors associated with the science of cell communication. Whereas cell sociology highlights the effects of cell-cell interaction, the science of cell signaling focuses on ... More


Dendrite development

Jennifer Bestman, Jorge Santos Da Silva, and Hollis T. Cline

in Dendrites

Published in print:
2007
Published Online:
March 2012
ISBN:
9780198566564
eISBN:
9780191724206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566564.003.0003
Subject:
Neuroscience, Molecular and Cellular Systems

The emergence of dendritic arbor structure in vivo occurs in the context of a developing functional nervous system. It is therefore of utmost importance to consider the interaction between ... More


Bertil Hille

Larry R. Squire

in The History of Neuroscience in Autobiography: Volume 7

Published in print:
2011
Published Online:
January 2012
ISBN:
9780195396133
eISBN:
9780199918409
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195396133.003.0004
Subject:
Neuroscience, History of Neuroscience

Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na+ and K+ channels of axons can be distinguished by drugs such as ... More


Cell signalling pathways involved in the regulation of vascular smooth muscle contraction and relaxation

Kevin Malarkey, Dorothy Aidulis, Christopher M. Belham, Anne Graham, Angela McLees, Andrew Paul, and Robin Plevin

in The Pharmacology of Vascular Smooth Muscle

Published in print:
1996
Published Online:
March 2012
ISBN:
9780192623874
eISBN:
9780191724671
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192623874.003.0007
Subject:
Neuroscience, Sensory and Motor Systems

A vast array of agonists regulate smooth muscle function by interacting with specific receptors located upon the cell membrane. This results in the activation of intracellular signalling pathways and ... More


CNS responses to peripheral insults

Jan Pieter Konsman and Giamal N. Luheshi

in Immune and Inflammatory Responses in the Nervous System

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198509806
eISBN:
9780191724596
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509806.003.0005
Subject:
Neuroscience, Disorders of the Nervous System

This chapter examines the importance of the central nervous components of the acute phase response (APR) for the host as well as the central nervous system (CNS) structures and immune-to-brain ... More


Using Control Theory to Study Biology*

Brian P. Ingalls, Tau-Mu Yi, and Pablo A. Iglesias

in System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.003.0012
Subject:
Mathematics, Mathematical Biology

This chapter presents a framework ideally suited to an analysis of dynamic systems. Tools from control theory can be applied to elucidate the functioning of self-regulating (homeostatic) systems and ... More


Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus

Roshni D. Thakkar, Ruimin Wang, Gangadhara R. Sareddy, Ratna K. Vadlamudi, and Darrell W. Brann

in Estrogens and Memory: Basic Research and Clinical Implications

Published in print:
2020
Published Online:
February 2020
ISBN:
9780190645908
eISBN:
9780190645922
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190645908.003.0024
Subject:
Psychology, Cognitive Neuroscience

The steroid hormone 17β‎-estradiol (E2) is neuroprotective in several neurodegenerative conditions, including cerebral ischemia, traumatic brain injury, and Alzheimer’s disease (AD). This chapter ... More


NMDA receptor targeting

Heike Hering and Morgan Sheng

in Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels

Published in print:
2002
Published Online:
March 2012
ISBN:
9780192632241
eISBN:
9780191724763
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192632241.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems

The N-methyl-d-aspartate (NMDA) class of ionotropic glutamate receptor has received special attention because it is critical for many forms of activity-dependent synaptic plasticity, some of which ... More


Suppression of Nogo-A to Enhance CNS Repair

Willi Roman and Schwab Martin E.

in Cerebral Plasticity: New Perspectives

Published in print:
2011
Published Online:
August 2013
ISBN:
9780262015233
eISBN:
9780262295444
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262015233.003.0029
Subject:
Neuroscience, Research and Theory

This chapter concentrates on the characteristics of Nogo-A and its signaling pathway components in neurite growth inhibition and describes mechanisms of central nervous system (CNS) repair after ... More


Methods to Identify Cellular Architecture and Dynamics from Experimental Data

Rudiyanto Gunawan, Kapil G. Gadkar, and Francis J. Doyle

in System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.003.0011
Subject:
Mathematics, Mathematical Biology

This chapter highlights the methodologies and challenges in the reverse engineering of cellular networks, in particular the identification of network dynamics using engineering approaches. The ... More


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