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In Search of Madness: Schizophrenia and Neuroscience

R. Walter Heinrichs

Published in print:
2001
Published Online:
May 2009
ISBN:
9780195122190
eISBN:
9780199865482
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195122190.001.0001
Subject:
Neuroscience, Behavioral Neuroscience

This book evaluates the progress of schizophrenia science by summarizing what is known about how patients with the illness differ from healthy people. The tools of meta-analysis are first explained ... More


The Unity of Consciousness

Tim Bayne

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199215386
eISBN:
9780191594786
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199215386.001.0001
Subject:
Philosophy, Philosophy of Mind, General

One of the features of consciousness that has been largely overlooked in recent treatments of the topic is its unity. What is the unity of consciousness? To what degree might consciousness be ... More


Bioethics and the Brain

Walter Glannon

Published in print:
2006
Published Online:
January 2007
ISBN:
9780195307788
eISBN:
9780199867431
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195307788.001.0001
Subject:
Philosophy, Moral Philosophy

Our ability to map and intervene in the structure of the human brain is proceeding at a very quick rate. Advances in psychiatry, neurology, and neurosurgery have given us fresh insights into the ... More


Cortical Oscillations in Health and Disease

Roger Traub, MD and Miles Whittington, PhD

Published in print:
2010
Published Online:
May 2010
ISBN:
9780195342796
eISBN:
9780199776276
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195342796.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems, Development

This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions ... More


Language unbound: genomic conflict and psychosis in the origin of modern humans

Bernard J Crespi

in Sociobiology of Communication: an interdisciplinary perspective

Published in print:
2008
Published Online:
September 2008
ISBN:
9780199216840
eISBN:
9780191712043
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199216840.003.0013
Subject:
Biology, Animal Biology, Evolutionary Biology / Genetics

Human social communication is impaired in the two primary disorders of the ‘social brain’, autism, and schizophrenia. This chapter describes a new hypothesis for the role of language in the evolution ... More


The Parahippocampal Region: Organization and Role in Cognitive Function

Menno Witter and Floris Wouterlood (eds)

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198509172
eISBN:
9780191724626
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509172.001.0001
Subject:
Neuroscience, Sensory and Motor Systems

Advances in imaging technologies have enabled researchers to build on the evidence obtained from lesion and behavioural studies to propose a range of functions for the parahippocampal region. It is ... More


Family Psychoeducation for Serious Mental Illness

Harriet P. Lefley

Published in print:
2009
Published Online:
September 2009
ISBN:
9780195340495
eISBN:
9780199863792
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195340495.001.0001
Subject:
Social Work, Health and Mental Health, Children and Families

This book gives an overview of family psychoeducation as an evidence-based psychosocial treatment for schizophrenia and other major psychiatric disorders. Family psychoeducation has produced a robust ... More


Schizophrenia

Lars Bertram

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0020
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Efforts to identify the genes that modulate the risk for schizophrenia (SZ) have met with only limited success. This is at least in part due to problems that aggravate epidemiologic research in many ... More


Genetic Dissection of Dopamine-Mediated Prefrontal-Striatal Mechanisms and Its Relationship to Schizophrenia

Hao-Yang Tan and Daniel R. Weinberger

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0013
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter examines findings through which heritable human neuroimaging intermediate phenotypes could provide a window to examine genetic mechanisms of active prefrontal cognitive processing ... More


Dopamine Dysfunction in Schizophrenia

Anissa Abi-Dargham, Mark Slifstein, Larry Kegeles, and Marc Laruelle

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0036
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Schizophrenia presents with multiple clinical features, ranging from positive symptoms (hallucinations, delusions, and thought disorder) to negative symptoms (social withdrawal, poverty of speech and ... More


Neuropharmacological Profiles of Antipsychotic Drugs

Bryan L. Roth and Sarah C. Rogan

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0037
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter reviews the state of psychopharmacological therapy for schizophrenia, covering both Food and Drug Administration (FDA), approved typical and atypical drugs, and emerging molecular ... More


How Antipsychotics Work: Linking Receptors to Response

Nathalie Ginovart and Shitij Kapur

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0038
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Schizophrenia is a chronic and disabling disease that typically begins during adolescence or early adult life and severely impacts psychosocial functioning. There is no known single cause of ... More


Dopamine Dysfunction in Schizophrenia: From Genetic Susceptibility to Cognitive Impairment

Heike Tost, Shabnam Hakimi, and Andreas Meyer-Lindenberg

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0039
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter provides an overview of the causes and effects of dopamine dysfunction in schizophrenia. In doing so, it summarizes historical perspectives and our current scientific knowledge about the ... More


Studies in the Neuropsychology of Attention

Allan F. Mirsky and Connie C. Duncan

in Luria's Legacy in the 21st Century

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195176704
eISBN:
9780199864706
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195176704.003.0006
Subject:
Neuroscience, History of Neuroscience

This chapter reviews the history of research on attention, including studies generated during wartime, and accounts of the impairment seen in brain-injured soldiers, as described by Luria and ... More


Animals—Property or Persons?

Gary L. Francione

in Animal Rights: Current Debates and New Directions

Published in print:
2005
Published Online:
March 2012
ISBN:
9780195305104
eISBN:
9780199850556
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195305104.003.0006
Subject:
Political Science, Environmental Politics

This chapter argues that the human attitude towards animals can best be described as moral schizophrenia. It explains that this moral schizophrenia is related to the status of animals as property, ... More


Personalized Medicine and Integrative Neuroscience: Toward Consensus Markers for Disorders of Brain Health

Leanne M. Williams and Evian Gordon

in Integrative Neuroscience and Personalized Medicine

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.003.0003
Subject:
Neuroscience, Disorders of the Nervous System

In the emerging new paradigm of “Personalized Medicine,” the goal is to shift the treatment for brain-related illness from trial and error into a bull’s-eye. To date, much of the research in ... More


Personalized Medicine for Schizophrenia

Jacob S. Ballon, Ragy R. Girgis, and Jeffrey A. Lieberman

in Integrative Neuroscience and Personalized Medicine

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.003.0006
Subject:
Neuroscience, Disorders of the Nervous System

This chapter discusses the potential for personalized medicine as it applies to schizophrenia, one of the most severe mental disorders. The first half of this chapter will address the genetics of ... More


The Role of Neuroimaging Biomarkers in Personalized Medicine for Neurodegenerative and Psychiatric Disorders

Ellen M. Migo, Steve C.R. Williams, William R. Crum, Matthew J. Kempton, and Ulrich Ettinger

in Integrative Neuroscience and Personalized Medicine

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.003.0008
Subject:
Neuroscience, Disorders of the Nervous System

There is a clear need for biomarkers in neuro-degenerative and psychiatric disorders for both early and differential diagnosis, personalized prediction of treatment response, and in drug discovery. ... More


Families, Schizophrenia, And Other Major Disorders: historical background

Harriet P. Lefley

in Family Psychoeducation for Serious Mental Illness

Published in print:
2009
Published Online:
September 2009
ISBN:
9780195340495
eISBN:
9780199863792
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195340495.003.0003
Subject:
Social Work, Health and Mental Health, Children and Families

This chapter provides historical background and discusses etiological theories, deinstitutionalization, and stressors for families coping with psychiatric disorders. Situational stressors involve ... More


Theoretical Premises and research overviews: the evidence for family psychoeducation

Harriet P. Lefley

in Family Psychoeducation for Serious Mental Illness

Published in print:
2009
Published Online:
September 2009
ISBN:
9780195340495
eISBN:
9780199863792
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195340495.003.0004
Subject:
Social Work, Health and Mental Health, Children and Families

This chapter provides a distillation of the theoretical premises underlying family psychoeducation (FPE) and the large research overviews that support its efficacy. FPE is based on the basic premise ... More


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