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Ultimate Riddle: Origin of Cellular Life

Franklin M. Harold

in In Search of Cell History: The Evolution of Life's Building Blocks

Published in print:
2014
Published Online:
May 2015
ISBN:
9780226174143
eISBN:
9780226174310
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226174310.003.0010
Subject:
Biology, Biochemistry / Molecular Biology

In all of biology, there is no more consequential problem than the origin of life; yet despite the expenditure of much effort and ink over the past seventy years a satisfactory answer continues to ... More


The Chicken and Egg Problem

John Maynard Smith and Eors Szathmáry

in The Major Transitions in Evolution

Published in print:
1997
Published Online:
November 2020
ISBN:
9780198502944
eISBN:
9780191919237
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198502944.003.0009
Subject:
Earth Sciences and Geography, Palaeontology: Earth Sciences

The most fundamental distinction in biology is between nucleic acids, with their role as carriers of information, and proteins, which generate the phenotype. In existing organisms, nucleic acids ... More


Phosphotransfer and Nucleotidyltransfer

Perry A. Frey and Adrian D. Hegeman

in Enzymatic Reaction Mechanisms

Published in print:
2007
Published Online:
November 2020
ISBN:
9780195122589
eISBN:
9780197565469
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195122589.003.0014
Subject:
Chemistry, Organic Chemistry

Phosphotransferases, phosphatases, and nucleotidyltransferases catalyze nucleophilic substitution at phosphorus. They constitute a dominant class of enzymes in intermediary metabolism, energy ... More


The Origin of Translation and the Genetic Code

John Maynard Smith and Eors Szathmary

in The Major Transitions in Evolution

Published in print:
1997
Published Online:
November 2020
ISBN:
9780198502944
eISBN:
9780191919237
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198502944.003.0010
Subject:
Earth Sciences and Geography, Palaeontology: Earth Sciences

The origin of the code is perhaps the most perplexing problem in evolutionary biology. The existing translational machinery is at the same time so complex, so universal, and so essential that it is ... More


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