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The interaction of water with organic solutes The interaction of water with organic solutes

Timothy J. Bradley

in Animal Osmoregulation

Published in print:
2008
Published Online:
April 2010
ISBN:
9780198569961
eISBN:
9780191728273
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569961.003.0003
Subject:
Biology, Animal Biology

The aqueous environments both inside and surrounding animal cells profoundly affect the structure and function of molecules and membranes. Solutes dissolved in water are surrounded by a shell of ... More


Probabilistic models and their impact on the accuracy of reconstructed ancestral protein sequences

Tal Pupko, Adi Doron-Faigenboim, David A. Liberles, and Gina M. Cannarozzi

in Ancestral Sequence Reconstruction

Published in print:
2007
Published Online:
September 2008
ISBN:
9780199299188
eISBN:
9780191714979
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299188.003.0004
Subject:
Biology, Evolutionary Biology / Genetics

Modeling of sequence evolution is fundamental to ancestral sequence reconstruction. Care must be taken in choosing a model, however, as the use of unrealistic models can lead to erroneous ... More


Novel molecules

Andreas Wagner

in The Origins of Evolutionary Innovations: A Theory of Transformative Change in Living Systems

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199692590
eISBN:
9780191774829
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199692590.003.0066
Subject:
Biology, Evolutionary Biology / Genetics

A growing body of evidence points to the existence of genotype networks in both protein and RNA phenotypes, and to their importance for evolutionary innovation. This evidence comes from comparative ... More


Protein residue networks

Ernesto Estrada

in The Structure of Complex Networks: Theory and Applications

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199591756
eISBN:
9780191774959
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199591756.003.0014
Subject:
Physics, Theoretical, Computational, and Statistical Physics

This chapter analyses the three-dimensional structure of proteins represented as residue networks. It starts by introducing the structure of proteins and how protein residue networks can be ... More


Ordering Objects

Hallam Stevens

in Life Out of Sequence: A Data-Driven History of Bioinformatics

Published in print:
2013
Published Online:
May 2014
ISBN:
9780226080178
eISBN:
9780226080345
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226080345.003.0006
Subject:
History, History of Science, Technology, and Medicine

This chapter explores the role of databases in scientific knowledge-making using one prominent example: GenBank. Biological databases, organized with computers, cannot be thought of as just ... More


Principles of protein structure

Jay F. Storz

in Hemoglobin: Insights into protein structure, function, and evolution

Published in print:
2018
Published Online:
December 2018
ISBN:
9780198810681
eISBN:
9780191847929
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198810681.003.0001
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

Chapter 1 reviews basic principles of protein structure—the nature of proteins as polymers of amino acids, the variety of amino acids, and the way in which the physicochemical properties of amino ... More


Computing the Structure of Large Complexes: Modeling the 16S Ribosoma RNA

R. Chen and D. Fink

in Biological NMR Spectroscopy

Published in print:
1997
Published Online:
November 2020
ISBN:
9780195094688
eISBN:
9780197560754
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195094688.003.0025
Subject:
Chemistry, Organic Chemistry

Ribosomes are the sites of messenger RNA (mRNA) translation to protein, and thus are crucial to the normal functioning of all cells. These ... More


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