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Gene Pleiotropy and Evolution of Protein Sequence

Xun Gu

in Statistical Theory and Methods for Evolutionary Genomics

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199213269
eISBN:
9780191594762
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213269.003.0008
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

The concept of gene pleiotropy may play a key role in developing an integrated view of protein evolution. Although the capacity of a gene that may affect multiple phenotypic characters has been used ... More


Electron density fitting and structure validation

Mike Carson

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0013
Subject:
Biology, Biochemistry / Molecular Biology

The Human Genome Project went three-dimensional in late 2000. ‘Structural genomics’ efforts will determine the structures of thousands of new proteins over the few years. These initiatives seek to ... More


Models of amino acid and codon substitution

ZIHENG YANG

in Computational Molecular Evolution

Published in print:
2006
Published Online:
April 2010
ISBN:
9780198567028
eISBN:
9780191728280
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198567028.003.0002
Subject:
Biology, Evolutionary Biology / Genetics

Chapter 1 discussed continuous-time Markov chain models of nucleotide substitution and their application to estimate the distance between two nucleotide sequences. This chapter discusses similar ... More


Ordering Objects

Hallam Stevens

in Life Out of Sequence: A Data-Driven History of Bioinformatics

Published in print:
2013
Published Online:
May 2014
ISBN:
9780226080178
eISBN:
9780226080345
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226080345.003.0006
Subject:
History, History of Science, Technology, and Medicine

This chapter explores the role of databases in scientific knowledge-making using one prominent example: GenBank. Biological databases, organized with computers, cannot be thought of as just ... More


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