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 Spatial Learning and the Selectivity of Hippocampal Place Fields: Modulation by Dopamine

Kathryn M. Gill and Sheri J. Y. Mizumori

in Hippocampal Place Fields: Relevance to Learning and Memory

Published in print:
2008
Published Online:
May 2008
ISBN:
9780195323245
eISBN:
9780199869268
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195323245.003.0020
Subject:
Psychology, Cognitive Neuroscience

This chapter compares the putative mechanisms by which dopamine selectively affects learning that is thought to be mediated by functionally distinct brain regions, such as the hippocampus and dorsal ... More


Synaptic Plasticity in the Hippocampus

Bliss Tim, Collingridge Graham, and Morris Richard

in The Hippocampus Book

Published in print:
2006
Published Online:
May 2009
ISBN:
9780195100273
eISBN:
9780199864133
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195100273.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience

The chapter opens with a brief historical account of the first two decades of research into about long-term potentiation (LTP) and long-term depression (LTD). Section 10.2 discusses the various ... More


Cellular Plasticity Mechanisms

Howard Eichenbaum and Neal J. Cohen

in From Conditioning to Conscious Recollection: Memory systems of the brain

Published in print:
2004
Published Online:
January 2008
ISBN:
9780195178043
eISBN:
9780199871223
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195178043.003.0003
Subject:
Psychology, Cognitive Psychology

This chapter reviews recent progress towards an understanding of synaptic plasticity resulting in increased synaptic efficacy as the main candidate for a cellular mechanism of memory. The most ... More


Short-term plasticity: fatigue and potentiation

Daniel Kernell

in The Motoneurone and its Muscle Fibres

Published in print:
2006
Published Online:
September 2009
ISBN:
9780198526551
eISBN:
9780191723896
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198526551.003.0009
Subject:
Neuroscience, Molecular and Cellular Systems

The functional properties of neurones, synapses, and muscles often change as a result of preceding use. In the short term (minutes to hours), such changes are typically rather rapidly reversible and ... More


Introduction

Edmund T. Rolls

in Memory, Attention, and Decision-Making: A Unifying Computational Neuroscience Approach

Published in print:
2007
Published Online:
September 2009
ISBN:
9780199232703
eISBN:
9780191724046
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199232703.003.0001
Subject:
Neuroscience, Behavioral Neuroscience

This introductory chapter discusses neurons, neurons in a network, synaptic modification, long-term potentiation and long-term depression, and distributed representations. It also details the fine ... More


Causal Relevance and Manipulation

Carl F. Craver

in Explaining the Brain

Published in print:
2007
Published Online:
January 2009
ISBN:
9780199299317
eISBN:
9780191715075
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299317.003.0003
Subject:
Philosophy, Philosophy of Mind, Philosophy of Science

This chapter presents a view of causal relevance that accommodates the mechanistic fragility and historical contingency of neuroscientific generalizations but that nonetheless satisfies constraints ... More


Excitatory Amino Acid Transmission in Health and Disease

Robert Balazs, Richard J. Bridges, and Carl W. Cotman

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.001.0001
Subject:
Neuroscience, Sensory and Motor Systems

This book provides a comprehensive, easy-to-read survey of excitatory amino acids and synaptic transmission. It begins with descriptions of the structure, function, and pharmacology of both the ... More


Overview and Perspective

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0001
Subject:
Neuroscience, Sensory and Motor Systems

L-Glutamate (Glu) is the most prevalent neurotransmitter in the mammalian central nervous system (CNS) and is responsible for mediating the majority of its excitatory signaling. From the start, ... More


Excitatory Amino Acid Transmission and Synaptic Plasticity

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0011
Subject:
Neuroscience, Sensory and Motor Systems

Activity-dependent, long-lasting synaptic enhancement induced by neuronal stimulation, known as long-term potentiation (LTP), is not unique to the hippocampus; rather, it seems to be a fundamental ... More


Cellular Mechanisms of Memory: Complex Circuits

Howard Eichenbaum

in The Cognitive Neuroscience of Memory: An Introduction

Published in print:
2011
Published Online:
May 2012
ISBN:
9780199778614
eISBN:
9780199932962
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199778614.003.0003
Subject:
Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems

This chapter reviews some of the progress toward a full characterization of one particular form of synaptic plasticity observed in the mammalian brain called long-term potentiation (LTP). LTP is only ... More


Neurobiology Of Chronic Pain

Min Zhuo

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems

Understanding the neurobiology of sensory synapses in the central nervous system provides us with basic knowledge of physiological and pathological pain, and has the potential to reveal possible drug ... More


Terje Lømo

Larry R. Squire

in The History of Neuroscience in Autobiography: Volume 7

Published in print:
2011
Published Online:
January 2012
ISBN:
9780195396133
eISBN:
9780199918409
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195396133.003.0009
Subject:
Neuroscience, History of Neuroscience

Terje Lømo discovered long term potentiation (LTP) and with Tim Bliss did the first systematic study of LTP. Lømo discovered that evoked muscle impulse activity per se controlled the properties of ... More


Cellular Mechanisms of Memory: Complex Circuits

Howard Eichenbaum

in The Cognitive Neuroscience of Memory: An Introduction

Published in print:
2002
Published Online:
May 2009
ISBN:
9780195141740
eISBN:
9780199865741
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141740.003.0003
Subject:
Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems

This chapter reviews recent progress toward a full characterization of one particular form of synaptic plasticity observed in the mammalian brain called long-term potentiation (LTP). LTP can be ... More


Framing Maps of Research Findings

Alcino J. Silva, Anthony Landreth, and John Bickle

in Engineering the Next Revolution in Neuroscience: The New Science of Experiment Planning

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199731756
eISBN:
9780199367658
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199731756.003.0002
Subject:
Neuroscience, Molecular and Cellular Systems, Techniques

This chapter describes both a taxonomy of experiments and a set of principles that any scientist can use to build graphical abstractions of research findings (research maps). Although the chapter ... More


A Framework for Molecular and Cellular Cognition

Alcino J. Silva, Anthony Landreth, and John Bickle

in Engineering the Next Revolution in Neuroscience: The New Science of Experiment Planning

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199731756
eISBN:
9780199367658
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199731756.003.0003
Subject:
Neuroscience, Molecular and Cellular Systems, Techniques

The majority of the case studies in this book come from learning and memory studies in the field of molecular and cellular cognition, and this chapter includes a primer to this neuroscience field. ... More


The Power of Convergence

Alcino J. Silva, Anthony Landreth, and John Bickle

in Engineering the Next Revolution in Neuroscience: The New Science of Experiment Planning

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199731756
eISBN:
9780199367658
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199731756.003.0004
Subject:
Neuroscience, Molecular and Cellular Systems, Techniques

In molecular and cellular cognition, there are three types of experiments that can be carried out to test whether A causes B (A→B): The magnitude of A can either be (1) increased or (2) decreased, ... More


Ruling out the Probable to Argue for the Possible

Alcino J. Silva, Anthony Landreth, and John Bickle

in Engineering the Next Revolution in Neuroscience: The New Science of Experiment Planning

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199731756
eISBN:
9780199367658
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199731756.003.0005
Subject:
Neuroscience, Molecular and Cellular Systems, Techniques

Integration Analyses are the routines used implicitly or explicitly by neuroscientists in the evaluation of experiments. Integration efforts are most visible in the introductions and conclusions of ... More


Resonating Experiments

Alcino J. Silva, Anthony Landreth, and John Bickle

in Engineering the Next Revolution in Neuroscience: The New Science of Experiment Planning

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199731756
eISBN:
9780199367658
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199731756.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems, Techniques

Replication of findings is critical and central to science. When similar or even identical experiments are carried out, the results are expected to be compatible and consistent. When they are not, ... More


A Dream Within Reach: Building Automated Research Maps

Alcino J. Silva, Anthony Landreth, and John Bickle

in Engineering the Next Revolution in Neuroscience: The New Science of Experiment Planning

Published in print:
2013
Published Online:
January 2014
ISBN:
9780199731756
eISBN:
9780199367658
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199731756.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems, Techniques

Imagine a computer screen with a glowing map of every phenomenon studied in neuroscience, linked by constellations of hypothesized causal connections. Clicking on any one of these connections would ... More


Repetitive Nerve Stimulation Studies

Jay A. Liveson and Dong M. Ma

in Laboratory Reference for Clinical Neurophysiology

Published in print:
1999
Published Online:
March 2012
ISBN:
9780195129243
eISBN:
9780199847792
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195129243.003.0018
Subject:
Neuroscience, Techniques

The presynaptic region releases acetylcholine from an immediately available primary store and from a secondary store which can be easily mobilized. With each subsequent nerve impulse, the primary, ... More


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