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The role of epidemiology in assessing the potential clinical impact of pharmacogenomics

David L. Veenstra

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0027
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

A promising area of genomics is the use of information about genetic variation to guide drug therapy, a field known as pharmacogenomics. Pharmacogenomic applications can be broadly categorized into ... More


Personalized Medicine for Schizophrenia

Jacob S. Ballon, Ragy R. Girgis, and Jeffrey A. Lieberman

in Integrative Neuroscience and Personalized Medicine

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.003.0006
Subject:
Neuroscience, Disorders of the Nervous System

This chapter discusses the potential for personalized medicine as it applies to schizophrenia, one of the most severe mental disorders. The first half of this chapter will address the genetics of ... More


Copy number variation in health and susceptibility to disease

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0004
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

In this chapter submicroscopic structural variation is described with a particular focus on copy number variation. There is a growing body of evidence to show that copy number variation is a common ... More


Concluding remarks and future directions

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0015
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

This final chapter seeks to provide a brief overview of some of the important insights that have been established from work investigating human genetic diversity. The remarkable range of human ... More


Overcoming “Premarket Syndrome”: Promoting Better Postmarket Surveillance in an Evolving Drug-Development Context

Shannon Gibson and Trudo Lemmens

in FDA in the Twenty-First Century: The Challenges of Regulating Drugs and New Technologies

Published in print:
2015
Published Online:
May 2016
ISBN:
9780231171182
eISBN:
9780231540070
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231171182.003.0019
Subject:
Law, Medical Law

This chapter explores both the promises and risks associated with rising interest in niche market drug development and concurrently, how drug regulatory reform efforts towards the “lifecycle” ... More


The Genealogy of a Gene: Patents, HIV/AIDS, and Race

Myles W. Jackson

Published in print:
2015
Published Online:
September 2015
ISBN:
9780262028660
eISBN:
9780262327190
Item type:
book
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262028660.001.0001
Subject:
History, History of Science, Technology, and Medicine

This book uses the story of the CCR5 gene to investigate the interrelationships among science, technology, and society. Mapping the varied ‘genealogy’ of CCR5- intellectual property, natural ... More


Searching for a role for genomics in the right to health

Lisa Eckstein

in Advancing the Human Right to Health

Published in print:
2013
Published Online:
September 2013
ISBN:
9780199661619
eISBN:
9780191765056
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199661619.003.0027
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter takes an optimistic view of the future role of genomic technology in the right to health. It first discusses the early expectations of genomic technologies for advancing health outcomes, ... More


Race, Difference, and Genes

Myles W. Jackson

in The Genealogy of a Gene: Patents, HIV/AIDS, and Race

Published in print:
2015
Published Online:
September 2015
ISBN:
9780262028660
eISBN:
9780262327190
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262028660.003.0008
Subject:
History, History of Science, Technology, and Medicine

This chapter situates the CCR5 gene, specifically the Δ‎32 allele, in the contexts of four distinct yet related enterprises- race and genomics, Big Pharma, personalized medicine, and personal ... More


Pharmacogenomics

Joel T. Dudley and Konrad J. Karczewski

in Exploring Personal Genomics

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199644483
eISBN:
9780191774577
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199644483.003.0007
Subject:
Biology, Evolutionary Biology / Genetics

This chapter defines and explores what is called pharmacogenomics. It's broad definition states that it is the study of the relationship between variation in drug effects (pharmacology) and genetic ... More


Capitalizing [on] Race in Drug Development

Sheldon Krimsky

in Race in a Bottle: The Story of BiDil and Racialized Medicine in a Post-Genomic Age

Published in print:
2014
Published Online:
November 2015
ISBN:
9780231162999
eISBN:
9780231531276
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231162999.003.0004
Subject:
Public Health and Epidemiology, Public Health

This chapter provides a close reading of the FDA hearing that approved the race-specific indication for BiDil, in which the racial frame played a critical role in shaping how the committee reviewed ... More


Not Fade Away: The Persistence of Race and the Politics of the “Meantime” in Pharmacogenomics

Thom van Dooren

in Race in a Bottle: The Story of BiDil and Racialized Medicine in a Post-Genomic Age

Published in print:
2014
Published Online:
November 2015
ISBN:
9780231162999
eISBN:
9780231531276
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231162999.003.0006
Subject:
Public Health and Epidemiology, Public Health

This chapter examines the broader forces driving the persistent use of race in biomedical research and practice. It explores “the politics of the meantime” in pharmacogenomics, arguing that debates ... More


Race in the Genomic Age

Michael Yudell and J. Craig Venter

in Race Unmasked: Biology and Race in the Twentieth Century

Published in print:
2014
Published Online:
November 2015
ISBN:
9780231168748
eISBN:
9780231537995
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231168748.003.0012
Subject:
Sociology, Race and Ethnicity

This chapter analyzes the relationship between molecular and evolutionary biology. By the mid-1960s, a new generation of evolutionary biologists—including Richard Lewontin and Jack Hubby—attempted to ... More


The Value of Cytochrome P450 2C19 Pharmacogenomic Information for Patients Receiving Clopidogrel Therapy Following a Major Cardiovascular Event: Evidence from Geisinger

Rebecca A. Pulk, Jove Graham, Frank R. Lichtenberg, Daniel Maeng, Marc S. Williams, and Eric Wright

in Economic Dimensions of Personalized and Precision Medicine

Published in print:
2019
Published Online:
September 2019
ISBN:
9780226611068
eISBN:
9780226611235
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226611235.003.0011
Subject:
Economics and Finance, Microeconomics

Dual antiplatelet therapy, combining a P2Y12 inhibitor and aspirin, is central to management of patients with acute coronary syndromes. Clopidogrel is a commonly prescribed thienopyridine P2Y12 ... More


Just Genetics: The Ethical Challenges of Personalized Medicine

Leonard M. Fleck

in Medicine and Social Justice: Essays on the Distribution of Health Care

Published in print:
2012
Published Online:
May 2015
ISBN:
9780199744206
eISBN:
9780190267551
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:osobl/9780199744206.003.0038
Subject:
Philosophy, Moral Philosophy

This chapter examines the impact of some new medical knowledge on the obligations of medical professionals to their patients, with particular emphasis on the ethical challenges of personalized ... More


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