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Molecular and Genetic Events in Neoplastic Transformation

AYSE E. ERSON and ELIZABETH M. PETTY

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0004
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter illustrates some of the basic molecular and genetic mechanisms that underlie the development of cancer. The chapter is organized into four main sections. The first section examines ... More


Cancer

Robert L. Perlman

in Evolution and Medicine

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199661718
eISBN:
9780191774720
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199661718.003.0006
Subject:
Biology, Evolutionary Biology / Genetics

Cancer exemplifies the evolutionary theory of aging. The incidence of most cancers increases with age and more than half of all cancers are detected in people over 60. Evolution and selection can ... More


The Origin of Cancer

Jeffrey Ecsedy and David Hunter

in Textbook of Cancer Epidemiology

Published in print:
2008
Published Online:
September 2009
ISBN:
9780195311174
eISBN:
9780199865093
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195311174.003.0003
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

One of the major goals in cancer research is to elucidate the molecular and cellular events driving the progression of cells from a normal to a cancerous state. This transformation relies on the ... More


Understanding Cancer

Cathy Hughes

in Adult Nursing Practice: Using evidence in care

Published in print:
2012
Published Online:
November 2020
ISBN:
9780199697410
eISBN:
9780191918476
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199697410.003.0014
Subject:
Clinical Medicine and Allied Health, Nursing

The aim of this chapter is provide an overview of cancer, a biologically similar, but diverse, group of diseases. Understanding the disease process will ... More


Targeted Therapy and Clinical Cancer Research

Peter Keating and Alberto Cambrosio

in Cancer on Trial: Oncology as a New Style of Practice

Published in print:
2012
Published Online:
September 2013
ISBN:
9780226428918
eISBN:
9780226428932
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226428932.003.0154
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the major turning points in the clinical trial process and examines the consequences of the oncogene revolution for the conduct of clinical cancer trials. It begins with the ... More


The Origins of “Dynamic Reciprocity”: Mina Bissell’s Expansive Picture of Cancer Causation

Anya Plutynski

in Dreamers, Visionaries, and Revolutionaries in the Life Sciences

Published in print:
2018
Published Online:
January 2019
ISBN:
9780226569871
eISBN:
9780226570075
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226570075.003.0007
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses Mina Bissell's pathbreaking research on cancer. Along with her colleagues and students, Bissell focused her attention on how the causal pathways regulating cell behavior were a ... More


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