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RNA crystallogenesis

Benoît Masquida, Boris François, Andreas Werner, and Eric Westhof

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0014
Subject:
Biology, Biochemistry / Molecular Biology

The number of RNA crystal structures has increased in an exponential manner mainly due to the fact that RNA is increasingly viewed as a predominant part of biological processes such as translation, ... More


Huntington's Disease

Oliver Quarrell

Published in print:
2020
Published Online:
February 2021
ISBN:
9780198844389
eISBN:
9780191926815
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198844389.001.0001
Subject:
Clinical Medicine and Allied Health, Clinical Medicine

Huntington’s disease (HD)―the facts provides an overview of the condition aimed at families and carers understanding the condition. It describes the key features of: a movement disorder, disturbance ... More


Transplantation of neuronal and nonneuronal cells into the brain

H. Widner

in Immune Responses in the Nervous System

Published in print:
1997
Published Online:
March 2012
ISBN:
9781872748795
eISBN:
9780191724381
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9781872748795.003.0009
Subject:
Neuroscience, Disorders of the Nervous System

Transplantation into the central nervous system has the potential to develop into a very powerful therapeutic approach for a variety of neurological disorders. This chapter discusses the principles ... More


Sequence, Salt, Charge, and the Stability of DNA at High Pressure

Robert B. Macgregor Jr and John Q. Wu

in High Pressure Effects in Molecular Biophysics and Enzymology

Published in print:
1996
Published Online:
November 2020
ISBN:
9780195097221
eISBN:
9780197560839
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195097221.003.0014
Subject:
Chemistry, Organic Chemistry

The effect of pressure on the helix-coil transition temperature (Tm) is reported for the double-stranded polymers poly(dA)poly(dT), poly[d(A-T)], poly[d(l-C], and poly[d(G-C] and triple-stranded ... More


Clinical research

Oliver Quarrell

in Huntington's Disease

Published in print:
2020
Published Online:
February 2021
ISBN:
9780198844389
eISBN:
9780191926815
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198844389.003.0012
Subject:
Clinical Medicine and Allied Health, Clinical Medicine

This chapter explains some of the research activities which are currently in place. It describes the global research platform called ENROLL-HD. It also describes the process of undertaking a clinical ... More


A Revolution in Peptide Synthesis

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0010
Subject:
Public Health and Epidemiology, Public Health

This chapter reflects on the revolution in peptide synthesis that began in 1949, when Robert Bruce Merrifield developed a method called solid-phase peptide synthesis. Working in the laboratory of ... More


Osmotic and Hydrostatic Pressure as Tools to Study Molecular Recognition

Stephen G. Sligar and Clifford R. Robinson

in High Pressure Effects in Molecular Biophysics and Enzymology

Published in print:
1996
Published Online:
November 2020
ISBN:
9780195097221
eISBN:
9780197560839
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195097221.003.0026
Subject:
Chemistry, Organic Chemistry

The question of molecular recognition is a central paradigm of molecular biology, playing central roles in most, if not all, cellular processes. Failed recognition events have been implicated in ... More


Chemists Who Are Leaders in Academia or Organizations

Jeannette E. Brown

in African American Women Chemists in the Modern Era

Published in print:
2018
Published Online:
November 2020
ISBN:
9780190615178
eISBN:
9780197559673
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190615178.003.0008
Subject:
Chemistry, History of Chemistry

Amanda Bryant-Friedrich (Fig. 4.1) is Dean of the College of Graduate Studies at the University of Toledo (Toledo). Amanda was born in Enfield, NC, a small town about fifteen miles from the North ... More


The Chicken and Egg Problem

John Maynard Smith and Eors Szathmáry

in The Major Transitions in Evolution

Published in print:
1997
Published Online:
November 2020
ISBN:
9780198502944
eISBN:
9780191919237
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198502944.003.0009
Subject:
Earth Sciences and Geography, Palaeontology: Earth Sciences

The most fundamental distinction in biology is between nucleic acids, with their role as carriers of information, and proteins, which generate the phenotype. In existing organisms, nucleic acids ... More


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