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Alzheimer’s Disease–Related Mechanisms of Neuronal Dysfunction and Degeneration: Studies in Human Cortical Neurons

Jorge Busciglio and Atul Deshpande

in From Development to Degeneration and Regeneration of the Nervous System

Published in print:
2008
Published Online:
May 2009
ISBN:
9780195369007
eISBN:
9780199865253
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195369007.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems, Development

This chapter reviews recent work illustrating the utilization of human cortical neurons for the study of molecular mechanisms of β-amyloid (Aβ) and tau-related neuronal degeneration relevant to ... More


The Nigro-Striatal DA Neurons and Mechanisms of Their Degeneration in Parkinson’s Disease

Kjell Fuxe, Daniel Marcellino, Tiziana Antonelli, Giuseppa Mudó, Paul Manger, Susanna Genedani, Luca Ferraro, Natale Belluardo, Sergio Tanganelli, and Luigi F. Agnati

in From Development to Degeneration and Regeneration of the Nervous System

Published in print:
2008
Published Online:
May 2009
ISBN:
9780195369007
eISBN:
9780199865253
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195369007.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems, Development

This chapter focuses on the link between correct mitochondrial function and the function of the plasma membrane ion channels and receptors, especially KATPM channels, P2x7 channels, and Cav 1.3 Ca2+ ... More


Degeneration in Canine Brain Aging

Elizabeth Head

in From Development to Degeneration and Regeneration of the Nervous System

Published in print:
2008
Published Online:
May 2009
ISBN:
9780195369007
eISBN:
9780199865253
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195369007.003.0009
Subject:
Neuroscience, Molecular and Cellular Systems, Development

This chapter discusses some of the neurobiological characteristics of the aging dog brain. Aged canines develop signs of neuronal, white matter, and vascular degeneration as observed in human brain ... More


Neuroimmune Interactions That Operate In The Development And Progression Of Inflammatory Demyelinating Diseases: Lessons From Pathogenesis Of Multiple Sclerosis

Enrico Fainardi and Massimiliano Castellazzi

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0012
Subject:
Neuroscience, Molecular and Cellular Systems

Multiple sclerosis (MS) is considered an autoimmune chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal damage. The view of MS as a “two-stage ... More


Cytokines and neurodegeneration

Sarah Loddick and Nancy Rothwell

in Immune and Inflammatory Responses in the Nervous System

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198509806
eISBN:
9780191724596
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509806.003.0007
Subject:
Neuroscience, Disorders of the Nervous System

This chapter examines the role of cytokines in neurodegeneration, considering the methodological approaches and evidence for their contribution, likely mechanisms of expression and action, and ... More


Cytokines and neurodegeneration

Nancy Rothwell, Sarah Loddick, and Catherine Lawrence

in Immune Responses in the Nervous System

Published in print:
1997
Published Online:
March 2012
ISBN:
9781872748795
eISBN:
9780191724381
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9781872748795.003.0004
Subject:
Neuroscience, Disorders of the Nervous System

Cytokine is the term used to describe a large and expanding group or family of polypeptides which can be synthesized by most cell types, and influence numerous biological processes. Recent research ... More


Central nervous system immune reactions in Alzheimer's disease

Patrick L. McGeer and Edith G. McGeer

in Immune Responses in the Nervous System

Published in print:
1997
Published Online:
March 2012
ISBN:
9781872748795
eISBN:
9780191724381
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9781872748795.003.0007
Subject:
Neuroscience, Disorders of the Nervous System

Alzheimer's disease (AD) is a relentlessly progressive dementing disorder with an incidence that increases very sharply with age. Of the many potential bases for neurodegeneration in AD, ... More


Neuroprotection

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

in Brain Damage, Brain Repair

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198523376
eISBN:
9780191724534
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523376.003.0007
Subject:
Neuroscience, Techniques

Excitoxic damage, metabolic imbalance, oxidative stress, and calcium influx are each capable of inducing cell death by both necrotic and apoptotic mechanisms. If these various mechanisms contribute, ... More


Frontotemporal lobar degeneration

Jared Narvid and Maria Luisa Gorno-Tempini

in Cognitive Neurology: A clinical textbook

Published in print:
2008
Published Online:
March 2012
ISBN:
9780198569275
eISBN:
9780191724213
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569275.003.0013
Subject:
Neuroscience, Techniques

Frontotemporal lobar degeneration (FTLD) is a syndrome of focal, often asymmetric, neurodegeneration presenting clinically as a progressive dementia associated with focal atrophy of the frontal ... More


Animal Models of Multiple Neurotransmitter Interactions in Alzheimer's Disease

V. Haroutunian, W. Wallace, A. C. Santucci, and K. L. Davis

in Brain and Memory: Modulation and Mediation of Neuroplasticity

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195082944
eISBN:
9780199847877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082944.003.0007
Subject:
Psychology, Cognitive Neuroscience

Alzheimer's disease (AD) represents one neurodegenerative disorder whose etiology remains unknown. Animal model systems for AD are further hampered by the absence of the tools necessary to duplicate ... More


Brain Aromatase and Neuroprotection in Mammals

Iñigo Azcoitia, Maria Angeles Arevalo, and Luis Miguel Garcia-Segura

in Brain Aromatase, Estrogens, and Behavior

Published in print:
2012
Published Online:
January 2013
ISBN:
9780199841196
eISBN:
9780199979837
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199841196.003.0019
Subject:
Neuroscience, Neuroendocrine and Autonomic

Recent studies suggest that, at least under neurodegenerative conditions, local brain formation of estradiol by the enzyme aromatase is an endogenous neuroprotective mechanism. This chapter reviews ... More


Inducible Aromatase in Astroglia: Protection and Recovery from Neural Perturbation in Birds

Kelli A. Duncan and Colin J. Saldanha

in Brain Aromatase, Estrogens, and Behavior

Published in print:
2012
Published Online:
January 2013
ISBN:
9780199841196
eISBN:
9780199979837
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199841196.003.0020
Subject:
Neuroscience, Neuroendocrine and Autonomic

In the avian brain, aromatase is constitutive and inducible in neurons and glia respectively. Glial aromatase is rapidly and dramatically upregulated in astroglia (astrocytes and radial glia) ... More


Neurophysiological Correlates of Cortical Plasticity in the Normal and Diseased Human Brain

Rossini Paolo Maria and Melgari Jean-Marc

in Cerebral Plasticity: New Perspectives

Published in print:
2011
Published Online:
August 2013
ISBN:
9780262015233
eISBN:
9780262295444
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262015233.003.0023
Subject:
Neuroscience, Research and Theory

This chapter is concerned with the results of studies performed with neurophysiological techniques. Their integration with flow/metabolic methods constitutes, at present, the best way to evaluate ... More


Nerve Growth Factor and Alzheimer’s Disease: New Twists to an Old Story

Cattaneo Antonino

in Cerebral Plasticity: New Perspectives

Published in print:
2011
Published Online:
August 2013
ISBN:
9780262015233
eISBN:
9780262295444
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262015233.003.0026
Subject:
Neuroscience, Research and Theory

This chapter describes the connection between the nerve growth factor (NGF) and Alzheimer’s disease (AD). It reveals that NGF can be considered as an anti-amyloidogenic factor that normally keeps the ... More


Neurodegenerative Diseases: Where Are We Not Looking for Answers?

Walter J. Koroshetz and Lennart Mucke

in Translational Neuroscience: Toward New Therapies

Published in print:
2015
Published Online:
September 2016
ISBN:
9780262029865
eISBN:
9780262329859
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029865.003.0005
Subject:
Neuroscience, Research and Theory

As life expectancy increases, burden of illness soars. The growing magnitude of the health problem and numerous failed trials of agents once considered worth investment (e.g., Alzheimer, Parkinson, ... More


Neurodegenerative Disorders Other Than Multiple Sclerosis

Javier Fernández-Ruiz, Eva de Lago, María Gómez-Ruiz, Concepción García, Onintza Sagredo, and Moisés García-Arencibia

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0027
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

This chapter focuses on the neuroprotective properties of phytocannabinoids, beginning with a description of those cellular and molecular mechanisms and signaling pathways underlying these properties ... More


Phytocannabinoids in Degenerative and Inflammatory Retinal Diseases: Glaucoma, Age-Related Macular Degeneration, Diabetic Retinopathy, and Uveoretinitis

Heping Xu and Augusto Azuara-Blanco

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0033
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

Glaucoma, diabetic retinopathy, age-related macular degeneration, and intraocular inflammation (uveoretinitis) are the major causes of blindness in developed countries. Although different diseases ... More


Structural MRI in Alzheimer’s Disease: Are We Measuring the Right Stuff?

Briana S. Last, Batool Rizvi, and Adam M. Brickman

in Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach

Published in print:
2020
Published Online:
June 2020
ISBN:
9780190634230
eISBN:
9780190634254
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190634230.003.0010
Subject:
Psychology, Neuropsychology

Structural magnetic resonance imaging (MRI) is a powerful tool to visualize and quantitate morphological and pathological features of the aging brain. Most work that has used structural MRI to study ... More


The Creation of Art in the Setting of Dementia

Indre V. Viskontas and Suzee E. Lee

in Art, Aesthetics, and the Brain

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199670000
eISBN:
9780191793479
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199670000.003.0018
Subject:
Psychology, Cognitive Psychology, Social Psychology

Countering the traditional emphasis on loss that dominates much of the neurological literature, some authors have recently chosen to focus on the positive changes that may accompany neurological ... More


Epilogue: Neuroscience in the Nazi era meets the modern age—ongoing legacies and controversies

Lawrence A. Zeidman

in Brain Science under the Swastika: Ethical Violations, Resistance, and Victimization of Neuroscientists in Nazi Europe

Published in print:
2020
Published Online:
June 2020
ISBN:
9780198728634
eISBN:
9780191882951
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198728634.003.0014
Subject:
Psychology, Evolutionary Psychology, Social Psychology

In recent decades, there has been a more critical examination of the Nazi past within German and Austrian neuroscience. The Spiegelgrund euthanasia brains and brain parts in Vienna were finally ... More


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