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Theranostics and Translation toward Personalized Medicine for Multiple Sclerosis

Ariel Miller, Tamar Paperna, Opher Caspi, Izabella Lejbkowicz, Elsebeth Staun-Ram, and Nili Avidan

in Integrative Neuroscience and Personalized Medicine

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.003.0011
Subject:
Neuroscience, Disorders of the Nervous System

Recently, medicine began moving to more informed healthcare management and medical treatment guided by diagnostics, termed, theranostics. In the last decade, the search for markers for disease ... More


Overview of clinical aspects of multiple sclerosis, including cognitive deficit

W. IAN McDONALD

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0033
Subject:
Neuroscience, Disorders of the Nervous System

One of the most striking characteristics of multiple sclerosis is how complete recovery usually is after quite devastating relapses early in the course of the disease. The lesions nevertheless ... More


The neuropsychological presentation and treatment of demyelinating disorders

Peter A. Arnett and Amanda R. Rabinowitz

in The Handbook of Clinical Neuropsychology

Published in print:
2010
Published Online:
September 2010
ISBN:
9780199234110
eISBN:
9780191594250
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199234110.003.029
Subject:
Psychology, Neuropsychology, Clinical Psychology

Clinical neuropsychologists play a pivotal role in assessment and treatment of multiple sclerosis (MS) patients. Neuropsychologists can first evaluate the extent to which tested difficulties ... More


Neuroimmune Interactions That Operate In The Development And Progression Of Inflammatory Demyelinating Diseases: Lessons From Pathogenesis Of Multiple Sclerosis

Enrico Fainardi and Massimiliano Castellazzi

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0012
Subject:
Neuroscience, Molecular and Cellular Systems

Multiple sclerosis (MS) is considered an autoimmune chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal damage. The view of MS as a “two-stage ... More


Neuropsychological problems: cognitive and affective disturbances in multiple sclerosis

Daniela Wyss and Jürg Kesselring

in Cognitive Neurology: A clinical textbook

Published in print:
2008
Published Online:
March 2012
ISBN:
9780198569275
eISBN:
9780191724213
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569275.003.0018
Subject:
Neuroscience, Techniques

This chapter aims to describe the frequency, pattern, and natural history of cognitive and affective disorders associated with multiple sclerosis (MS) and to discuss possible ways of coping with the ... More


Adaptive functional changes in the cerebral cortex during multiple sclerosis

Hasini Reddy

in Reprogramming the Cerebral Cortex: Plasticity following central and peripheral lesions

Published in print:
2006
Published Online:
September 2009
ISBN:
9780198528999
eISBN:
9780191723926
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198528999.003.0018
Subject:
Neuroscience, Disorders of the Nervous System

This chapter examines reorganization following damage due to the progression of multiple sclerosis in humans studied using functional magnetic resonance imaging (fMRI) and other imaging techniques. ... More


Inflammatory demyelination and axonopathy in the central nervous system

M. L. Cuzner and M. N. Woodroofe

in Immune and Inflammatory Responses in the Nervous System

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198509806
eISBN:
9780191724596
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509806.003.0009
Subject:
Neuroscience, Disorders of the Nervous System

This chapter examines axonopathy and inflammatory demyelination in the central nervous system (CNS). It explains that CNS inflammation in experimental allergic encephalomyelitis (EAE) is induced ... More


Pathology of the myelin sheath

SAMUEL K. LUDWIN

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0022
Subject:
Neuroscience, Disorders of the Nervous System

Diseases affecting the myelin sheath encompass a wide variety of clinical and experimental conditions. This chapter discusses the essentials of the processes of demyelination and remyelination, and ... More


Older Adults With Neurological Problems Without Significant Dementia

Gladys GonzáLez-Ramos

in Handbook of Social Work in Health and Aging

Published in print:
2006
Published Online:
April 2010
ISBN:
9780195173727
eISBN:
9780199893218
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195173727.003.0009
Subject:
Social Work, Health and Mental Health

This chapter covers two of the most prevalent neurological disorders, Parkinson's disease (PD) and multiple sclerosis (MS). Although both diseases typically can be quite debilitating and impact a ... More


Control of inflammation

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

in Brain Damage, Brain Repair

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198523376
eISBN:
9780191724534
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523376.003.0010
Subject:
Neuroscience, Techniques

While inflammatory diseases affecting the CNS can produce a huge range of symptoms, depending on the exact nature of the disease process, the range of therapeutic options in these conditions is ... More


Family carers of people with advanced organ failure and neurodegenerative disorders

Janice Brown and Julia Addingto-Hall

in Family Carers in Palliative Care: A guide for health and social care professionals

Published in print:
2008
Published Online:
November 2011
ISBN:
9780199216901
eISBN:
9780191730252
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199216901.003.0013
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making, Palliative Medicine Research

This chapter examines the needs, conditions, and experiences of family carers of people with neurodegenerative disorders and advanced organ failure. It focuses on six disorders which currently ... More


Neuroglia

Helmut Kettenmann and Bruce R. Ransom (eds)

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.001.0001
Subject:
Neuroscience, Development, Disorders of the Nervous System

This book details the basic biology and function of glial cells. It covers the entire field of glial research from the basic molecular and cellular properties of these cells to their involvement in ... More


Cannabis and Multiple Sclerosis

Gareth Pryce and David Baker

in Handbook of Cannabis

Published in print:
2014
Published Online:
January 2015
ISBN:
9780199662685
eISBN:
9780191787560
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199662685.003.0026
Subject:
Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience

There are numerous reports that multiple sclerosis (MS) patients have for many years been self-medicating with illegal street cannabis to alleviate the symptoms associated with MS. These anecdotal ... More


Sleep and neurological disorders

D.A. Cohen and A. Roy

in Sleep, Health and Society: From Aetiology to Public Health

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199566594
eISBN:
9780191595066
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199566594.003.0009
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

While sleep affects the functioning of multiple organ systems, it is fundamentally a neurological process. This chapter provides a conceptual framework for understanding the reciprocal interactions ... More


Immunomodulation in the Nervous and Vascular Systems During Inflammation and Autoimmunity: the Role of T Regulatory Cells

Kokona Chatzantoni and Athanasia Mouzaki

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0014
Subject:
Neuroscience, Molecular and Cellular Systems

The immune system is characterized by a complex network of cells and organs specialized to extinguish foreign invaders or malfunctioning cells of the organism. Although innate immunity, B-cell ... More


Immune Responses in the Nervous System

Nancy J. Rothwell (ed.)

Published in print:
1997
Published Online:
March 2012
ISBN:
9781872748795
eISBN:
9780191724381
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9781872748795.001.0001
Subject:
Neuroscience, Disorders of the Nervous System

This new edition covers recent advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and ... More


Immune responses in the central nervous system in inflammatory demyelinating disease

M. L. Cuzner and T. Smith

in Immune Responses in the Nervous System

Published in print:
1997
Published Online:
March 2012
ISBN:
9781872748795
eISBN:
9780191724381
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9781872748795.003.0006
Subject:
Neuroscience, Disorders of the Nervous System

Detailed immunocytochemical studies of the inflammatory lesion in post-mortem brain from acute cases of multiple sclerosis (MS) reinforce the growing conviction that the immune reaction can be ... More


Chronic neurological diseases

Andrew Davies and Ilora Finlay

in Oral Care in Advanced Disease

Published in print:
2005
Published Online:
November 2011
ISBN:
9780192632432
eISBN:
9780191730375
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192632432.003.0017
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology

Patients with advanced chronic neurological diseases are commonly faced with oral problems. These problems in oral health have a great impact on the quality of life of this group of patients. This ... More


Psychological Stress and Autoimmune Disease

HAROLD G. KOENIG and HARVEY JAY COHEN

in The Link Between Religion and Health: Psychoneuroimmunology and the Faith Factor

Published in print:
2002
Published Online:
April 2010
ISBN:
9780195143607
eISBN:
9780199893256
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195143607.003.0011
Subject:
Psychology, Neuropsychology

This chapter looks at diseases which result not from a hypoactive immune system but rather from an immune system functioning in an exaggerated or uncontrolled fashion. This is seen in autoimmune ... More


Jean-Martin Charcot: Clinical Neurology Comes of Age

Stanley Finger

in Minds Behind the Brain: A history of the pioneers and their discoveries

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195181821
eISBN:
9780199865277
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195181821.003.0012
Subject:
Neuroscience, History of Neuroscience

During the first half of the 19th century, most neurological diseases were categorized on the basis of a single feature, such as a paralysis or a tremor. Labeling and classifying neurological ... More


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