Michael Graziano
- Published in print:
- 2009
- Published Online:
- May 2009
- ISBN:
- 9780195326703
- eISBN:
- 9780199864867
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326703.001.0001
- Subject:
- Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience
This book offers a fundamental new theory of motor cortex organization: the rendering of the movement repertoire onto the cortex. The action repertoire of an animal is highly dimensional, whereas the ...
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This book offers a fundamental new theory of motor cortex organization: the rendering of the movement repertoire onto the cortex. The action repertoire of an animal is highly dimensional, whereas the cortical sheet is two-dimensional. Rendering the action space onto the cortex therefore results in a complex pattern, explaining the otherwise inexplicable details of motor cortex organization. This book includes a complete history of motor cortex research from its discovery to the present, a discussion of the major issues in motor cortex research, and an account of recent experiments that led to the book's “action map” view. Though focused on motor cortex, the book includes a range of topics from an explanation of how primates put food in their mouths, to the origins of social behavior such as smiling and laughing, to the mysterious link between movement disorders and autism.Less
This book offers a fundamental new theory of motor cortex organization: the rendering of the movement repertoire onto the cortex. The action repertoire of an animal is highly dimensional, whereas the cortical sheet is two-dimensional. Rendering the action space onto the cortex therefore results in a complex pattern, explaining the otherwise inexplicable details of motor cortex organization. This book includes a complete history of motor cortex research from its discovery to the present, a discussion of the major issues in motor cortex research, and an account of recent experiments that led to the book's “action map” view. Though focused on motor cortex, the book includes a range of topics from an explanation of how primates put food in their mouths, to the origins of social behavior such as smiling and laughing, to the mysterious link between movement disorders and autism.
Michael S. A. Graziano
- Published in print:
- 2009
- Published Online:
- May 2009
- ISBN:
- 9780195326703
- eISBN:
- 9780199864867
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326703.003.0002
- Subject:
- Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience
This chapter discusses the emergence of dominant ideas about motor cortex. It traces motor cortex research from its beginning to motor maps of Penfield and Boldrey (1937) and Woolsey et al. (1952). ...
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This chapter discusses the emergence of dominant ideas about motor cortex. It traces motor cortex research from its beginning to motor maps of Penfield and Boldrey (1937) and Woolsey et al. (1952). This segment of the history is mainly about electrical stimulation applied to the surface of the cortex. Using this technique, researchers drew motor maps of greater and greater elaboration. After Penfield and Woolsey, more fine-grained techniques such as microstimulation and single-neuron recording were used to probe the details and reopened all the same questions and debates.Less
This chapter discusses the emergence of dominant ideas about motor cortex. It traces motor cortex research from its beginning to motor maps of Penfield and Boldrey (1937) and Woolsey et al. (1952). This segment of the history is mainly about electrical stimulation applied to the surface of the cortex. Using this technique, researchers drew motor maps of greater and greater elaboration. After Penfield and Woolsey, more fine-grained techniques such as microstimulation and single-neuron recording were used to probe the details and reopened all the same questions and debates.
Randolph J. Nudo and Ines Eisner-Janowicz
- Published in print:
- 2006
- Published Online:
- September 2009
- ISBN:
- 9780198528999
- eISBN:
- 9780191723926
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198528999.003.0012
- Subject:
- Neuroscience, Disorders of the Nervous System
This chapter begins by reviewing the sequence of events that results in neuronal injury after stroke. It then reviews the advantages and disadvantages of various animal models used to model stroke ...
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This chapter begins by reviewing the sequence of events that results in neuronal injury after stroke. It then reviews the advantages and disadvantages of various animal models used to model stroke and ischemic cortical injury. It considers the relationship of various aspects of behavioral assessment and the understanding of post-stroke plasticity and recovery. After a brief review of the organization of the motor cortex, the chapter reviews the evidence that neurophysiological and neuroanatomical plasticity occurs after cortical injury, emphasizing the role of postinjury behavior in the modulation of injury-induced changes. The cellular and synaptic basis for postinjury plasticity is briefly reviewed. Finally, the role of the intact hemisphere in recovery of function after unilateral cortical injury is discussed.Less
This chapter begins by reviewing the sequence of events that results in neuronal injury after stroke. It then reviews the advantages and disadvantages of various animal models used to model stroke and ischemic cortical injury. It considers the relationship of various aspects of behavioral assessment and the understanding of post-stroke plasticity and recovery. After a brief review of the organization of the motor cortex, the chapter reviews the evidence that neurophysiological and neuroanatomical plasticity occurs after cortical injury, emphasizing the role of postinjury behavior in the modulation of injury-induced changes. The cellular and synaptic basis for postinjury plasticity is briefly reviewed. Finally, the role of the intact hemisphere in recovery of function after unilateral cortical injury is discussed.
Michael S. A
- Published in print:
- 2010
- Published Online:
- February 2010
- ISBN:
- 9780195326598
- eISBN:
- 9780199864904
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326598.003.0023
- Subject:
- Psychology, Neuropsychology, Evolutionary Psychology
This chapter reviews evidence that motor cortex in primates is not organized according to topographic maps related to the body surface, but is organized according to species-typical motor behavior. ...
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This chapter reviews evidence that motor cortex in primates is not organized according to topographic maps related to the body surface, but is organized according to species-typical motor behavior. Microstimulation with behaviorally relevant time courses evokes basic movements such as bringing food to the mouth, climbing, or defensive responses. It is argued that primate motor cortex serves as an interface functionally specialized for producing species-typical actions.Less
This chapter reviews evidence that motor cortex in primates is not organized according to topographic maps related to the body surface, but is organized according to species-typical motor behavior. Microstimulation with behaviorally relevant time courses evokes basic movements such as bringing food to the mouth, climbing, or defensive responses. It is argued that primate motor cortex serves as an interface functionally specialized for producing species-typical actions.
Julien Doyon and Leslie G. Ungerleider
- Published in print:
- 2003
- Published Online:
- May 2009
- ISBN:
- 9780195140132
- eISBN:
- 9780199865307
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195140132.003.0013
- Subject:
- Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience
This chapter reviews the results of a large body of studies that examined the cerebral plasticity in the primary motor cortex (M1) using neurophysiological approaches in monkeys and rodents, or ...
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This chapter reviews the results of a large body of studies that examined the cerebral plasticity in the primary motor cortex (M1) using neurophysiological approaches in monkeys and rodents, or behavioral experiments using modern brain mapping techniques such as positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and transcranial magnetic stimulation (TMS) in human adults. It describes the plastic changes that occur within M1 over the course of learning in order to determine their role in the acquisition, consolidation, and long-term retention of new motor skilled behaviors. It discusses the physiological and neurobiological correlates of such plasticity to give insights into the underlying mechanisms for the representational functional changes associated with the learning and retention of a motor skill.Less
This chapter reviews the results of a large body of studies that examined the cerebral plasticity in the primary motor cortex (M1) using neurophysiological approaches in monkeys and rodents, or behavioral experiments using modern brain mapping techniques such as positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and transcranial magnetic stimulation (TMS) in human adults. It describes the plastic changes that occur within M1 over the course of learning in order to determine their role in the acquisition, consolidation, and long-term retention of new motor skilled behaviors. It discusses the physiological and neurobiological correlates of such plasticity to give insights into the underlying mechanisms for the representational functional changes associated with the learning and retention of a motor skill.
Nicholas G. Hatsopoulos, Maryam Saleh, and Julian A. Mattiello
- Published in print:
- 2010
- Published Online:
- February 2010
- ISBN:
- 9780195326598
- eISBN:
- 9780199864904
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326598.003.0014
- Subject:
- Psychology, Neuropsychology, Evolutionary Psychology
This chapter proposes that the motor cortex does not encode movement as any one simple Newtonian parameter of motion. Rather, if motor cortical neurons actually encode anything at all, they represent ...
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This chapter proposes that the motor cortex does not encode movement as any one simple Newtonian parameter of motion. Rather, if motor cortical neurons actually encode anything at all, they represent movement fragments. The chapter begins by defining the meaning of “encoding” in the nervous system. It then provides evidence against the contention that motor cortical neurons encode any simple movement parameter, and argues for the hypothesis that motor cortex may form a substrate where elementary movement fragments are assembled into motor behaviors. In the last part of the chapter, it is argued that encoding is only part of a full explanation of motor cortical functioning. The motor cortex not only encodes information but also transforms information by processing its inputs to generate its output, much like any information processing system.Less
This chapter proposes that the motor cortex does not encode movement as any one simple Newtonian parameter of motion. Rather, if motor cortical neurons actually encode anything at all, they represent movement fragments. The chapter begins by defining the meaning of “encoding” in the nervous system. It then provides evidence against the contention that motor cortical neurons encode any simple movement parameter, and argues for the hypothesis that motor cortex may form a substrate where elementary movement fragments are assembled into motor behaviors. In the last part of the chapter, it is argued that encoding is only part of a full explanation of motor cortical functioning. The motor cortex not only encodes information but also transforms information by processing its inputs to generate its output, much like any information processing system.
Wolf Muellbacher and Mark Hallett
- Published in print:
- 2006
- Published Online:
- September 2009
- ISBN:
- 9780198528999
- eISBN:
- 9780191723926
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198528999.003.0013
- Subject:
- Neuroscience, Disorders of the Nervous System
This chapter discusses neural remapping after a stroke with respect to maximal recovery, considering the effectiveness of current therapies, including TMS, physical therapy, pharmacological therapies ...
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This chapter discusses neural remapping after a stroke with respect to maximal recovery, considering the effectiveness of current therapies, including TMS, physical therapy, pharmacological therapies and their own work on inhibition therapies, in purposefully generating a new map following stroke-induced damage.Less
This chapter discusses neural remapping after a stroke with respect to maximal recovery, considering the effectiveness of current therapies, including TMS, physical therapy, pharmacological therapies and their own work on inhibition therapies, in purposefully generating a new map following stroke-induced damage.
Eiji Hoshi
- Published in print:
- 2007
- Published Online:
- September 2007
- ISBN:
- 9780195314274
- eISBN:
- 9780199786695
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195314274.003.0010
- Subject:
- Psychology, Cognitive Neuroscience
This chapter focuses on the differential involvement of multiple areas of the lateral frontal cortex in rule‐based behavior. It presents evidence obtained from physiological and anatomical studies of ...
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This chapter focuses on the differential involvement of multiple areas of the lateral frontal cortex in rule‐based behavior. It presents evidence obtained from physiological and anatomical studies of monkeys and discusses the specific role played by each area from the viewpoint of a hierarchical network within the lateral frontal cortex. It introduces several key types of neuronal activity found in the prefrontal, premotor, and primary motor cortices of macaque monkeys performing a variety of rule‐based behaviors, such as following location‐matching rules or shape‐matching rules.Less
This chapter focuses on the differential involvement of multiple areas of the lateral frontal cortex in rule‐based behavior. It presents evidence obtained from physiological and anatomical studies of monkeys and discusses the specific role played by each area from the viewpoint of a hierarchical network within the lateral frontal cortex. It introduces several key types of neuronal activity found in the prefrontal, premotor, and primary motor cortices of macaque monkeys performing a variety of rule‐based behaviors, such as following location‐matching rules or shape‐matching rules.
Michael S. A. Graziano
- Published in print:
- 2009
- Published Online:
- May 2009
- ISBN:
- 9780195326703
- eISBN:
- 9780199864867
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326703.003.0005
- Subject:
- Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience
Two main types of experiment have addressed the question of how neurons in motor cortex control movement. One type focuses on the descending pathways that map specific points in motor cortex to ...
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Two main types of experiment have addressed the question of how neurons in motor cortex control movement. One type focuses on the descending pathways that map specific points in motor cortex to specific muscles. A second type of experiment focuses on the activity of single neurons in motor cortex while the animal, usually a monkey, performs a complex task. These two approaches have resulted in contrasting descriptions of motor cortex. This chapter reviews these two major approaches to motor cortex. The first part summarizes experiments on the direct pathways from motor cortex, through the spinal cord, to the muscles, and how those pathways might control movement. The second part summarizes experiments on correlations between the activity of neurons in motor cortex and a variety of control variables related to the arm.Less
Two main types of experiment have addressed the question of how neurons in motor cortex control movement. One type focuses on the descending pathways that map specific points in motor cortex to specific muscles. A second type of experiment focuses on the activity of single neurons in motor cortex while the animal, usually a monkey, performs a complex task. These two approaches have resulted in contrasting descriptions of motor cortex. This chapter reviews these two major approaches to motor cortex. The first part summarizes experiments on the direct pathways from motor cortex, through the spinal cord, to the muscles, and how those pathways might control movement. The second part summarizes experiments on correlations between the activity of neurons in motor cortex and a variety of control variables related to the arm.
Michael S. A. Graziano
- Published in print:
- 2009
- Published Online:
- May 2009
- ISBN:
- 9780195326703
- eISBN:
- 9780199864867
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326703.003.0004
- Subject:
- Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience
The hypothesis of hierarchy in the cortical motor system has a long history of conflicting opinions. Whether any premotor cortex existed was initially controversial. Researchers then began to ...
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The hypothesis of hierarchy in the cortical motor system has a long history of conflicting opinions. Whether any premotor cortex existed was initially controversial. Researchers then began to describe not one but at least six premotor areas, and the exact properties of these areas are still debated. This chapter reviews the emergence of ideas on these many premotor areas.Less
The hypothesis of hierarchy in the cortical motor system has a long history of conflicting opinions. Whether any premotor cortex existed was initially controversial. Researchers then began to describe not one but at least six premotor areas, and the exact properties of these areas are still debated. This chapter reviews the emergence of ideas on these many premotor areas.
Jon H. Kaas and Yvonne Rothemund
- Published in print:
- 2006
- Published Online:
- September 2009
- ISBN:
- 9780198528999
- eISBN:
- 9780191723926
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198528999.003.0015
- Subject:
- Neuroscience, Disorders of the Nervous System
Damage to peripheral nerves or the central axons of those nerves in the spinal cord disrupts the normal flow of information to the brain, and the output of the brain via motor neuron projections to ...
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Damage to peripheral nerves or the central axons of those nerves in the spinal cord disrupts the normal flow of information to the brain, and the output of the brain via motor neuron projections to muscles. These lesions have immediate consequences for sensory processing and motor control, and start a process of compensation first involving rebalancing of inhibition and excitation in central circuits, followed by an array of changes in gene expression, neurotransmitters and receptor expression, synaptic adjustments and neuron growth and retraction. The changes, commonly referred to as reorganizations, often promote partial recoveries, but they can lead to perception errors and movement disorders. This chapter focuses on reorganizations that have been experimentally studied in monkeys, and compares the results with those that have been obtained in noninvasive studies in humans. The emphasis is on sensory and motor cortex, where reorganizations have most extensively been explored, but subcortical alterations related to cortical reorganizations are also reviewed.Less
Damage to peripheral nerves or the central axons of those nerves in the spinal cord disrupts the normal flow of information to the brain, and the output of the brain via motor neuron projections to muscles. These lesions have immediate consequences for sensory processing and motor control, and start a process of compensation first involving rebalancing of inhibition and excitation in central circuits, followed by an array of changes in gene expression, neurotransmitters and receptor expression, synaptic adjustments and neuron growth and retraction. The changes, commonly referred to as reorganizations, often promote partial recoveries, but they can lead to perception errors and movement disorders. This chapter focuses on reorganizations that have been experimentally studied in monkeys, and compares the results with those that have been obtained in noninvasive studies in humans. The emphasis is on sensory and motor cortex, where reorganizations have most extensively been explored, but subcortical alterations related to cortical reorganizations are also reviewed.
Michael S. A. Graziano
- Published in print:
- 2009
- Published Online:
- May 2009
- ISBN:
- 9780195326703
- eISBN:
- 9780199864867
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326703.003.0003
- Subject:
- Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience
This chapter begins by discussing the question of whether the musculature of the hand is controlled in a decomposed or in an integrated manner in the primary motor cortex. It then discusses ...
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This chapter begins by discussing the question of whether the musculature of the hand is controlled in a decomposed or in an integrated manner in the primary motor cortex. It then discusses integration among other body-part representations, and how this integration may develop through experience with complex actions.Less
This chapter begins by discussing the question of whether the musculature of the hand is controlled in a decomposed or in an integrated manner in the primary motor cortex. It then discusses integration among other body-part representations, and how this integration may develop through experience with complex actions.
Lynette A. Jones and Susan J. Lederman
- Published in print:
- 2006
- Published Online:
- September 2007
- ISBN:
- 9780195173154
- eISBN:
- 9780199786749
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195173154.003.0003
- Subject:
- Psychology, Cognitive Neuroscience
This chapter considers human hand function from a neurophysiological perspective and begins by highlighting several areas of controversy in this research area. The structure and function of the ...
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This chapter considers human hand function from a neurophysiological perspective and begins by highlighting several areas of controversy in this research area. The structure and function of the different types of sensory receptors embedded in the hand's skin, muscles, and joints are then described, together with the role of centrally generated corollary discharges in perception. The various classes of mechanoreceptors found in the glabrous and hairy skin of the hand are detailed and the neurophysiological functions of these tactile receptors are described. The properties of cutaneous thermoreceptors and muscle and joint receptors are reviewed and the sensory cortical projections of all these various sensory receptors are described. Finally, this chapter considers the areas in the human cerebral cortex that contribute directly to the control of hand movements.Less
This chapter considers human hand function from a neurophysiological perspective and begins by highlighting several areas of controversy in this research area. The structure and function of the different types of sensory receptors embedded in the hand's skin, muscles, and joints are then described, together with the role of centrally generated corollary discharges in perception. The various classes of mechanoreceptors found in the glabrous and hairy skin of the hand are detailed and the neurophysiological functions of these tactile receptors are described. The properties of cutaneous thermoreceptors and muscle and joint receptors are reviewed and the sensory cortical projections of all these various sensory receptors are described. Finally, this chapter considers the areas in the human cerebral cortex that contribute directly to the control of hand movements.
Hugo Merchant, Thomas Naselaris, Wilbert Zarco, Ramón Bartolo, Luis Prado, Oswaldo Pérez, and Juan Carlos Méndez
- Published in print:
- 2008
- Published Online:
- May 2009
- ISBN:
- 9780195369007
- eISBN:
- 9780199865253
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195369007.003.0013
- Subject:
- Neuroscience, Molecular and Cellular Systems, Development
The primary motor cortex (M1) maintains a dynamic representation of higher-order features of movement, most notably the direction of reaching. In fact, almost half of the cells in the arm region of ...
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The primary motor cortex (M1) maintains a dynamic representation of higher-order features of movement, most notably the direction of reaching. In fact, almost half of the cells in the arm region of the motor cortex show an orderly variation in activity as a function of the movement direction, with a peak of activity in their preferred direction (PD), and progressively lower rates for movements farther and farther away from the PD. This orderly variation of cell activity is characterized by the directional tuning curve that can be approximated by a cosine function. This chapter addresses the question: What are the anatomical bases for directional tuning? The micro- and macro-anatomical architecture of directional tuning in the motor cortex are discussed.Less
The primary motor cortex (M1) maintains a dynamic representation of higher-order features of movement, most notably the direction of reaching. In fact, almost half of the cells in the arm region of the motor cortex show an orderly variation in activity as a function of the movement direction, with a peak of activity in their preferred direction (PD), and progressively lower rates for movements farther and farther away from the PD. This orderly variation of cell activity is characterized by the directional tuning curve that can be approximated by a cosine function. This chapter addresses the question: What are the anatomical bases for directional tuning? The micro- and macro-anatomical architecture of directional tuning in the motor cortex are discussed.
Michael S. A. Graziano
- Published in print:
- 2009
- Published Online:
- May 2009
- ISBN:
- 9780195326703
- eISBN:
- 9780199864867
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326703.003.0001
- Subject:
- Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience
This introductory chapter begins with a backstory on the experiments that led to the proposition of two principles to explain the basic properties of motor cortex. One principle concerned the ...
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This introductory chapter begins with a backstory on the experiments that led to the proposition of two principles to explain the basic properties of motor cortex. One principle concerned the topographic layout of motor cortex, and the other concerned the neuronal mechanism by which motor cortex caused movement. A theoretical framework for understanding at least the outlines of motor cortex is described. An overview of the subsequent chapters is presented.Less
This introductory chapter begins with a backstory on the experiments that led to the proposition of two principles to explain the basic properties of motor cortex. One principle concerned the topographic layout of motor cortex, and the other concerned the neuronal mechanism by which motor cortex caused movement. A theoretical framework for understanding at least the outlines of motor cortex is described. An overview of the subsequent chapters is presented.
Roger D. Roger and Miles A. Whittington
- Published in print:
- 2010
- Published Online:
- May 2010
- ISBN:
- 9780195342796
- eISBN:
- 9780199776276
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195342796.003.0011
- Subject:
- Neuroscience, Molecular and Cellular Systems, Development
Neuromodulatory substances evoke beta2 oscillations in motor and secondary somatosensory cortex, that depend on gap junctions. In the latter case, the oscillations are only weakly dependent on ...
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Neuromodulatory substances evoke beta2 oscillations in motor and secondary somatosensory cortex, that depend on gap junctions. In the latter case, the oscillations are only weakly dependent on synaptic transmission. Beta2 is most prominent in intrinsically bursting layer 5 pyramidal cells (some of which are expected to contribute to the pyramidal tract, at least in primates). The oscillation is an emergent phenomenon, in that individual neurons are not oscillators at beta2 frequency. The period is determined in part by the “M” type of K+ current. Oscillations in deep and superficial cortical layers interact with one another. Gap junctions mediating beta2 are probably located on axons.Less
Neuromodulatory substances evoke beta2 oscillations in motor and secondary somatosensory cortex, that depend on gap junctions. In the latter case, the oscillations are only weakly dependent on synaptic transmission. Beta2 is most prominent in intrinsically bursting layer 5 pyramidal cells (some of which are expected to contribute to the pyramidal tract, at least in primates). The oscillation is an emergent phenomenon, in that individual neurons are not oscillators at beta2 frequency. The period is determined in part by the “M” type of K+ current. Oscillations in deep and superficial cortical layers interact with one another. Gap junctions mediating beta2 are probably located on axons.
Michael S. A. Graziano
- Published in print:
- 2009
- Published Online:
- May 2009
- ISBN:
- 9780195326703
- eISBN:
- 9780199864867
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195326703.003.0007
- Subject:
- Neuroscience, Sensory and Motor Systems, Behavioral Neuroscience
This chapter summarizes electrical stimulation studies in the macaque motor cortex, in which stimulation on a behaviorally relevant time scale evoked complex movements that resembled behaviorally ...
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This chapter summarizes electrical stimulation studies in the macaque motor cortex, in which stimulation on a behaviorally relevant time scale evoked complex movements that resembled behaviorally meaningful actions. It begins with a brief summary of methods followed by a summary of two sets of findings: first the quantitative profile of the evoked arm and hand movements, and second the manner in which evoked movements resemble actions in a monkey's natural behavioral repertoire. The chapter ends with a review of other experiments using similar stimulation techniques to study motor areas in a range of animal species.Less
This chapter summarizes electrical stimulation studies in the macaque motor cortex, in which stimulation on a behaviorally relevant time scale evoked complex movements that resembled behaviorally meaningful actions. It begins with a brief summary of methods followed by a summary of two sets of findings: first the quantitative profile of the evoked arm and hand movements, and second the manner in which evoked movements resemble actions in a monkey's natural behavioral repertoire. The chapter ends with a review of other experiments using similar stimulation techniques to study motor areas in a range of animal species.
Nick S. Ward and Richard S. J. Frackowiak
- Published in print:
- 2006
- Published Online:
- September 2009
- ISBN:
- 9780198528999
- eISBN:
- 9780191723926
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198528999.003.0014
- Subject:
- Neuroscience, Disorders of the Nervous System
This chapter uses functional magnetic resonance imaging (fMRI) to study reorganization following motor cortex damage resulting from a stroke. It describes high activity soon after the stroke followed ...
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This chapter uses functional magnetic resonance imaging (fMRI) to study reorganization following motor cortex damage resulting from a stroke. It describes high activity soon after the stroke followed by a gradual decrease, and activity patterns correlated to an increased or decreased behavioral outcome.Less
This chapter uses functional magnetic resonance imaging (fMRI) to study reorganization following motor cortex damage resulting from a stroke. It describes high activity soon after the stroke followed by a gradual decrease, and activity patterns correlated to an increased or decreased behavioral outcome.
Robert Porter and Roger Lemon
- Published in print:
- 1995
- Published Online:
- March 2012
- ISBN:
- 9780198523758
- eISBN:
- 9780191724404
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198523758.003.0002
- Subject:
- Neuroscience, Sensory and Motor Systems
Although the function of a particular cortical area is determined not so much by its intrinsic structure as by its extrinsic connections, its inputs and outputs, it is important to review the ...
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Although the function of a particular cortical area is determined not so much by its intrinsic structure as by its extrinsic connections, its inputs and outputs, it is important to review the intrinsic structure of the motor cortex with which these inputs, and the determinants of its functions, must interact. Intrinsic networks are available for selection by different inputs and are utilized in the organization of cortical outputs to the multiple sites which receive these projections. This chapter concentrates on the features of the motor cortex which distinguish it from other cortical areas. It describes in detail the sources of the inputs which operate on its intrinsic networks and gives special attention to the organization of its corticofugal outputs. In hierarchical models of mammalian motor systems, the motor cortex, and in particular its corticospinal output, are seen as executive structures. Nevertheless, it is now abundantly clear that the motor cortex is not independent and self-sufficient in these executive functions: it is itself under the influence of a large variety of different inputs, including some originating in the periphery.Less
Although the function of a particular cortical area is determined not so much by its intrinsic structure as by its extrinsic connections, its inputs and outputs, it is important to review the intrinsic structure of the motor cortex with which these inputs, and the determinants of its functions, must interact. Intrinsic networks are available for selection by different inputs and are utilized in the organization of cortical outputs to the multiple sites which receive these projections. This chapter concentrates on the features of the motor cortex which distinguish it from other cortical areas. It describes in detail the sources of the inputs which operate on its intrinsic networks and gives special attention to the organization of its corticofugal outputs. In hierarchical models of mammalian motor systems, the motor cortex, and in particular its corticospinal output, are seen as executive structures. Nevertheless, it is now abundantly clear that the motor cortex is not independent and self-sufficient in these executive functions: it is itself under the influence of a large variety of different inputs, including some originating in the periphery.
Beatriz Calvo-Merino
- Published in print:
- 2012
- Published Online:
- January 2013
- ISBN:
- 9780195393705
- eISBN:
- 9780199979271
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195393705.003.0016
- Subject:
- Psychology, Cognitive Psychology
The discovery of mirror neurons in the macaque monkey, or neurons in the premotor cortex that respond during the execution and perception of motor acts, established the first neurophysiological ...
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The discovery of mirror neurons in the macaque monkey, or neurons in the premotor cortex that respond during the execution and perception of motor acts, established the first neurophysiological integration of action and perception. Subsequent research has identified and characterized a similar mirror neuron system in human observers that is experience-dependent in that it responds most strongly during the observation of actions that fall within the observer’s motor repertoire. Furthermore, evidence is reviewed that indicates that the mirror neuron system plays a key role in the understanding of other people’s intentions from their actions.Less
The discovery of mirror neurons in the macaque monkey, or neurons in the premotor cortex that respond during the execution and perception of motor acts, established the first neurophysiological integration of action and perception. Subsequent research has identified and characterized a similar mirror neuron system in human observers that is experience-dependent in that it responds most strongly during the observation of actions that fall within the observer’s motor repertoire. Furthermore, evidence is reviewed that indicates that the mirror neuron system plays a key role in the understanding of other people’s intentions from their actions.
