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Antibodies

William R. Clark

in In Defense of Self: How the Immune System Really Works

Published in print:
2008
Published Online:
September 2008
ISBN:
9780195336634
eISBN:
9780199868568
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195336634.003.0002
Subject:
Biology, Disease Ecology / Epidemiology

This chapter describes the antibody arm of the adaptive immune system and how these proteins, produced by B lymphocytes, circulate throughout the body in blood and lymph and help remove microbes and ... More


Antibody Engineering: A Renaissance for Mab Therapeutics

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0008
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the emergence of engineered monoclonal antibodies (Mabs) in the 1990s. The failure of Centoxin to gain FDA approval prompted many in the biotechnology and pharmaceutical ... More


Hunting for the Elusive “Magic Bullet”

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0001
Subject:
History, History of Science, Technology, and Medicine

This chapter traces the history of the discovery of antibodies, from the late nineteenth-century theories of immunity to the development of monoclonal antibodies (Mabs) in 1975—a breakthrough that ... More


Breakthroughs at the Bench

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0003
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses how monoclonal antibodies (Mabs) opened new frontiers in research well beyond immunology and transformed the way scientists analyzed biological phenomena in the early 1980s. ... More


Joy, Disappointment, Determination: Early Clinical Tests

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0005
Subject:
History, History of Science, Technology, and Medicine

This chapter considers the development of monoclonal antibodies (Mabs) for cancer treatment. In the early 1980s, many scientists were optimistic that Mabs would defeat cancer. In 1982, John Minna of ... More


The DNA of Biotechnology

Michael Kinch

in Prescription for Change: The Looming Crisis in Drug Development

Published in print:
2016
Published Online:
May 2017
ISBN:
9781469630625
eISBN:
9781469630649
Item type:
chapter
Publisher:
University of North Carolina Press
DOI:
10.5149/northcarolina/9781469630625.003.0007
Subject:
Business and Management, Innovation

This chapter relates the birth of the biotechnology industry, whose origins can be traced back to the Spanish flu and which would later revolutionize both fundamental understanding of life as well as ... More


The First Medical Applications

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0004
Subject:
History, History of Science, Technology, and Medicine

This chapter describes the early clinical applications of monoclonal antibodies (Mabs). The technology offered so many different possibilities that it was difficult to know where to start. Many of ... More


A Quiet Revolution: The Legacy of Monoclonal Antibodies

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0010
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses legacy of monoclonal antibodies (Mabs). Mab therapeutics are some of the best-selling drugs in the world today. As of 2012 there were over thirty Mab drugs on the world market. ... More


The Wild West of Antibody Commercialization

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0006
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the pioneers who commercialized monoclonal antibodies (Mabs) from the late 1970s. Those who did so were entering totally uncharted territory. Not only was the technique still ... More


Blockbuster Mab Drugs

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0009
Subject:
History, History of Science, Technology, and Medicine

This chapter explores the development of rituximab and infliximab, two of the best-selling monoclonal antibody (Mab) therapeutics today. The evolution of these drugs not only illustrates how a single ... More


Levers in a Specific Industry—Biotechnology

in The Patent Crisis and How the Courts Can Solve It

Published in print:
2009
Published Online:
March 2013
ISBN:
9780226080611
eISBN:
9780226080635
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226080635.003.0011
Subject:
Law, Intellectual Property, IT, and Media Law

This chapter presents preliminary assessments of the economics of biotechnology, and describes how policy levers can and do apply in biotechnology. Taking the biotechnology industry as the case ... More


The Challenge of Monoclonal Antibody Drugs

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0007
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the efforts to develop monoclonal antibody (Mab) therapeutics. The quick commercialization of Mab diagnostics prompted many to assume that Mab therapeutics would soon reach the ... More


A Hesitant Start: Patents, Politics, and Process

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0002
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses how the dissemination of monoclonal antibodies (Mabs) involved complex negotiations between actors in numerous scientific laboratories across the world, negotiations that also ... More


The British Response

Geoffrey Owen and Michael M. Hopkins

in Science, the State, and the City: Britain's Struggle to Succeed in Biotechnology

Published in print:
2016
Published Online:
May 2016
ISBN:
9780198728009
eISBN:
9780191794308
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198728009.003.0003
Subject:
Business and Management, Innovation, International Business

The chapter describes the chain of events that led to the creation, with government support, of the UK’s first biotech firm, Celltech, in 1980. There followed a wave of start-ups as scientists and ... More


The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Lara V Marks

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
book
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.001.0001
Subject:
History, History of Science, Technology, and Medicine

This book tells the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are ... More


Sep-Con Articulation Process in Creative Discovery

Albert Rothenberg

in Flight from Wonder: An Investigation of Scientific Creativity

Published in print:
2014
Published Online:
November 2014
ISBN:
9780199988792
eISBN:
9780190214159
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199988792.003.0012
Subject:
Psychology, Cognitive Psychology

Verbatim descriptions are given of the use of the sep-con articulation process in creative discovery by Werner Arber on DNA restriction and modification, David Baltimore on reverse transcriptase, ... More


A New Way of Making Medicines

Geoffrey Owen and Michael M. Hopkins

in Science, the State, and the City: Britain's Struggle to Succeed in Biotechnology

Published in print:
2016
Published Online:
May 2016
ISBN:
9780198728009
eISBN:
9780191794308
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198728009.003.0001
Subject:
Business and Management, Innovation, International Business

This chapter introduces the term biotechnology and explains why it has been the subject of intense interest on the part of governments and investors around the world. It reviews the scientific ... More


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