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Statistical Theory and Methods for Evolutionary Genomics

Xun Gu

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199213269
eISBN:
9780191594762
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213269.001.0001
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

Evolutionary genomics is a relatively new research field with the ultimate goal of understanding the underlying evolutionary and genetic mechanisms for the emergence of genome complexity under ... More


Theranostics and Translation toward Personalized Medicine for Multiple Sclerosis

Ariel Miller, Tamar Paperna, Opher Caspi, Izabella Lejbkowicz, Elsebeth Staun-Ram, and Nili Avidan

in Integrative Neuroscience and Personalized Medicine

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.003.0011
Subject:
Neuroscience, Disorders of the Nervous System

Recently, medicine began moving to more informed healthcare management and medical treatment guided by diagnostics, termed, theranostics. In the last decade, the search for markers for disease ... More


Genetics of gene expression

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0011
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

This chapter discusses the role of genetic variation in modulating gene expression and how this can help resolve functionally important regulatory variants. The successful application of genetic ... More


Phylogenomic Expression Analysis between Duplicate Genes

Xun Gu

in Statistical Theory and Methods for Evolutionary Genomics

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199213269
eISBN:
9780191594762
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213269.003.0005
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

Microarray technology can simultaneously monitor the expression levels of thousands of genes across many experimental conditions or treatments, providing us with unique opportunities to investigate ... More


Genomic insights into life history evolution

Derek A. Roff

in Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199568765
eISBN:
9780191774591
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199568765.003.0002
Subject:
Biology, Evolutionary Biology / Genetics

This chapter addresses two issues in which molecular analyses are important for our understanding of life history evolution. First, information on the genomic regulation of trade-offs – a central ... More


Evolution and mechanisms of insect reproductive diapause: A plastic and pleiotropic life history syndrome

Paul S. Schmidt

in Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199568765
eISBN:
9780191774591
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199568765.003.0018
Subject:
Biology, Evolutionary Biology / Genetics

States of arrested development and reproductive quiescence have widespread effects on life histories in many taxa. Insects that inhabit seasonal environments often express a diapause syndrome which ... More


A Theoretical Overview of Genetic Maternal Effects: Evolutionary Predictions and Empirical Tests with Mammalian Data

Michael J. Wade, Nicholas K. Priest, and Tami E. Cruickshank

in Maternal Effects in Mammals

Published in print:
2009
Published Online:
February 2013
ISBN:
9780226501192
eISBN:
9780226501222
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226501222.003.0003
Subject:
Biology, Animal Behavior / Behavioral Ecology

This chapter reviews recent theoretical advances in relation to maternal-effect genes and the theory of relaxed selective constraint (RSC). It explains how to test theoretical predictions using ... More


Graphical Models and Multivariate Analysis of Microarray Data

Harri Kiiveri

in Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Published in print:
2014
Published Online:
December 2014
ISBN:
9780198709022
eISBN:
9780191779619
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198709022.003.0003
Subject:
Mathematics, Probability / Statistics, Biostatistics

The usual analysis of gene expression data ignores the correlation between gene expression values. Biologically, this assumption is unreasonable. The approach presented in this chapter allows for ... More


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