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Trace Metals in Host–Microbe Interactions: The Microbe Perspective

Jennifer S. Cavet, Robert D. Perry, Sascha Brunke, K. Heran Darwin, Carol A. Fierke, James A. Imlay, Michael E. P. Murphy, Anthony B. Schryvers, Dennis J. Thiele, and Jeffrey N. Weiser

in Trace Metals and Infectious Diseases

Published in print:
2015
Published Online:
May 2016
ISBN:
9780262029193
eISBN:
9780262327619
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029193.003.0007
Subject:
Public Health and Epidemiology, Public Health

Microbes must acquire metals for metabolic processes, with nearly a half of all enzymes requiring a metal cofactor for function, yet microbes can be poisoned by metals. The host innate immune ... More


Common Mechanisms of Bacterial Metal Homeostasis

James A. Imlay

in Trace Metals and Infectious Diseases

Published in print:
2015
Published Online:
May 2016
ISBN:
9780262029193
eISBN:
9780262327619
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029193.003.0005
Subject:
Public Health and Epidemiology, Public Health

Transition metals are required for the function of nearly half the enzymatic machinery of organisms. Metals compete for enzyme-binding sites and inappropriate metallation inhibits enzyme function. ... More


The Fate of Intracellular Metal Ions in Microbes

Slade A. Loutet, Anson C. K. Chan, Marek J. Kobylarz, Meghan M. Verstraete, Stephanie Pfaffen, Bin Ye, Angel L. Arrieta, and Michael E. P. Murphy

in Trace Metals and Infectious Diseases

Published in print:
2015
Published Online:
May 2016
ISBN:
9780262029193
eISBN:
9780262327619
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029193.003.0004
Subject:
Public Health and Epidemiology, Public Health

Metals are essential for all microorganisms; they are required as cofactors of enzymes that mediate metabolic processes which are indispensable for cellular energy production and growth. Some metals, ... More


Impact of Metals on Immune Response and Tolerance, and Modulation of Metal Metabolism during Infection

Günter Weiss

in Trace Metals and Infectious Diseases

Published in print:
2015
Published Online:
May 2016
ISBN:
9780262029193
eISBN:
9780262327619
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029193.003.0009
Subject:
Public Health and Epidemiology, Public Health

Several metals play important roles in host cell and microbial metabolism because they form a part of central enzymes that are essential, for example, for DNA synthesis, cellular respiration, and key ... More


Selenium and Mercury: Their Interactions and Roles in Living Organisms

Tamara García-Barrera

in Trace Metals and Infectious Diseases

Published in print:
2015
Published Online:
May 2016
ISBN:
9780262029193
eISBN:
9780262327619
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262029193.003.0014
Subject:
Public Health and Epidemiology, Public Health

The essential or toxic character of the elements depends not only on their concentration, but also on the chemical form in which they occur. This is the case of arsenobetaine, which has limited ... More


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