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Macromolecular Crystallography: conventional and high-throughput methods

Mark R. Sanderson and Jane V. Skelly (eds)

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.001.0001
Subject:
Biology, Biochemistry / Molecular Biology

Macromolecular crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of ... More


SAM EDWARDS AND THE STATISTICAL MECHANICS OF RUBBER

Paul M. Goldbart and Nigel Goldenfeld

in Stealing the Gold: A celebration of the pioneering physics of Sam Edwards

Published in print:
2004
Published Online:
September 2007
ISBN:
9780198528531
eISBN:
9780191713415
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198528531.003.0019
Subject:
Physics, Theoretical, Computational, and Statistical Physics

The statistical mechanics of cross-linked macromolecules requires simultaneous treatment of random polymer configurations, excluded-volume interactions, and the quenched disorder of the cross-links, ... More


Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules

Dmitri I. Svergun, Michel H. J. Koch, Peter A. Timmins, and Roland P. May

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199639533
eISBN:
9780191747731
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199639533.001.0001
Subject:
Physics, Crystallography: Physics

Small angle scattering of X-rays (SAXS) and neutrons (SANS) is an established method for the structural characterisation of biological objects in a broad size-range from individual macromolecules ... More


Strategies to apply when high‐quality crystals cannot be obtained

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

in Macromolecular Crystallization and Crystal Perfection

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199213252
eISBN:
9780191707575
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213252.003.0006
Subject:
Physics, Crystallography: Physics

Once a crystal has been obtained that is suitable for crystallographic data collection using X‐rays or neutrons there are several strategies that may be combined to improve the quality and/or size of ... More


Conclusions and future prospects

Dmitri I. Svergun, Michel H. J. Koch, Peter A. Timmins, and Roland P. May

in Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199639533
eISBN:
9780191747731
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199639533.003.0011
Subject:
Physics, Crystallography: Physics

This chapter presents some final thoughts and future directions for SAS. SAS has become one of the major techniques in the armoury of the structural biologist. SAS is capable of determining the ... More


Micro- and noncrystalline materials

Jenny Pickworth Glusker and Kenneth N. Trueblood

in Crystal Structure Analysis: A Primer

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199576340
eISBN:
9780191917905
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199576340.003.0023
Subject:
Chemistry, Crystallography: Chemistry

The crystalline state is characterized by a high degree of internal order. There are two types of order that we will discuss here. One is chemical order, ... More


Outline of a crystal structure determination

Jenny Pickworth Glusker and Kenneth N. Trueblood

in Crystal Structure Analysis: A Primer

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199576340
eISBN:
9780191917905
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199576340.003.0024
Subject:
Chemistry, Crystallography: Chemistry

The stages in a crystal structure analysis by diffraction methods are summarized in Figure 14.1 for a substance with fewer than about 1000 atoms. The ... More


Polydisperse and interacting systems

Dmitri I. Svergun, Michel H. J. Koch, Peter A. Timmins, and Roland P. May

in Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199639533
eISBN:
9780191747731
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199639533.003.0006
Subject:
Physics, Crystallography: Physics

Chapter 5 deals with the systems, which deviate from the ideal monodisperse solutions. The most important cases of such systems are (i) solutions of particles differing in size, shape or conformation ... More


Quantitative description of the steady-state charge

Christopher L-H. Huang

in Intramembrane Charge Movements in Striated Muscle

Published in print:
1993
Published Online:
March 2012
ISBN:
9780198577492
eISBN:
9780191724190
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198577492.003.0008
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter explores applications of equilibrium thermodynamics and statistical principles to the derivation of some limiting properties expected for a capacitative charge in an electric field. The ... More


The derivation of trial structures. I. Analytical methods for direct phase determination

Jenny Pickworth Glusker and Kenneth N. Trueblood

in Crystal Structure Analysis: A Primer

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199576340
eISBN:
9780191917905
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199576340.003.0017
Subject:
Chemistry, Crystallography: Chemistry

As indicated at the start of Chapter 4, after the diffraction pattern has been recorded and measured, the next stage in a crystal structure determination ... More


The derivation of trial structures. II. Patterson, heavy-atom, and isomorphous replacement methods

Jenny Pickworth Glusker and Kenneth N. Trueblood

in Crystal Structure Analysis: A Primer

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199576340
eISBN:
9780191917905
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199576340.003.0018
Subject:
Chemistry, Crystallography: Chemistry

The two methods to be described here, the Patterson method and the isomorphous replacement method, have made it possible to determine the ... More


Anomalous scattering and absolute configuration

Jenny Pickworth Glusker and Kenneth N. Trueblood

in Crystal Structure Analysis: A Primer

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199576340
eISBN:
9780191917905
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199576340.003.0019
Subject:
Chemistry, Crystallography: Chemistry

The concept of the carbon atom with four bonds extending in a tetrahedral fashion was put forward by van’t Hoff and Le Bel in 1874. It coincided with the ... More


Refinement of the trial Structure

Jenny Pickworth Glusker and Kenneth N. Trueblood

in Crystal Structure Analysis: A Primer

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199576340
eISBN:
9780191917905
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199576340.003.0021
Subject:
Chemistry, Crystallography: Chemistry

When approximate positions have been determined for most, if not all, of the atoms, it is time to begin the refinement of the structure. In this process ... More


Protein crystallography

Giuseppe Zanotti

in Fundamentals of Crystallography

Published in print:
2011
Published Online:
December 2013
ISBN:
9780199573653
eISBN:
9780191775000
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199573653.003.0009
Subject:
Physics, Crystallography: Physics, Condensed Matter Physics / Materials

This chapter focuses on protein crystallography, a specialized branch of crystallography that investigates, by using diffraction techniques on single crystals, the three-dimensional structure of ... More


A 19F and 2H NMR Spectroscopic Investigation of the Interaction Between Nonionic Organic Contaminants and Dissolved Humic Material

Bruce E. Herbert and Paul M. Bertsch

in Nuclear Magnetic Resonance Spectroscopy in Environment Chemistry

Published in print:
1997
Published Online:
November 2020
ISBN:
9780195097511
eISBN:
9780197560853
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195097511.003.0009
Subject:
Chemistry, Environmental Chemistry

Interaction between nonionic organic contaminants (NOC) and natural organic matter strongly influences the fate and transport of NOC in the environment. ... More


Biological Macromolecules

Lawrence E. Hunter

in The Processes of Life: An Introduction to Molecular Biology

Published in print:
2009
Published Online:
August 2013
ISBN:
9780262013055
eISBN:
9780262255288
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262013055.003.0005
Subject:
Biology, Biochemistry / Molecular Biology

This chapter discusses biological macromolecules, proteins, and nucleic acids. First, it discusses the chemical structure of proteins, the properties of amino acids that make up most proteins, ... More


Reductionism and Developmental Molecular Biology

in Darwinian Reductionism: Or, How to Stop Worrying and Love Molecular Biology

Published in print:
2006
Published Online:
March 2013
ISBN:
9780226727295
eISBN:
9780226727318
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226727318.003.0003
Subject:
Philosophy, Philosophy of Science

This chapter argues that the sudden success of molecular developmental biology will turn reductionism from an exercise in philosophical handwaving into “normal science.” It shows that before ... More


Thermodynamics (a reminder)

Giuseppe (Joe) Zaccai

in From Molecules to Living Organisms: An Interplay Between Biology and Physics: Lecture Notes of the Les Houches School of Physics: Volume 102, July 2014

Published in print:
2016
Published Online:
March 2016
ISBN:
9780198752950
eISBN:
9780191814426
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198752950.003.0004
Subject:
Physics, Soft Matter / Biological Physics

Biological processes take place in an aqueous environment, and the discovery and characterization of biological macromolecules is tightly interwoven with the development of physical chemistry and ... More


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