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Synaptic Plasticity in the Hippocampus

Bliss Tim, Collingridge Graham, and Morris Richard

in The Hippocampus Book

Published in print:
2006
Published Online:
May 2009
ISBN:
9780195100273
eISBN:
9780199864133
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195100273.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience

The chapter opens with a brief historical account of the first two decades of research into about long-term potentiation (LTP) and long-term depression (LTD). Section 10.2 discusses the various ... More


Cellular Mechanisms of Memory: Complex Circuits

Howard Eichenbaum

in The Cognitive Neuroscience of Memory: An Introduction

Published in print:
2002
Published Online:
May 2009
ISBN:
9780195141740
eISBN:
9780199865741
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195141740.003.0003
Subject:
Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems

This chapter reviews recent progress toward a full characterization of one particular form of synaptic plasticity observed in the mammalian brain called long-term potentiation (LTP). LTP can be ... More


Neural Mechanisms of Associative Memory:: Role of Long-Term Potentiation

Serge Laroche, Valérie Doyére, Catherine Rédini-Del Negro, and François Burette

in Brain and Memory: Modulation and Mediation of Neuroplasticity

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195082944
eISBN:
9780199847877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082944.003.0017
Subject:
Psychology, Cognitive Neuroscience

This chapter considers different angles of attack that have been pursued in testing the long-term potentiation (LTP) hypothesis in the context of associative learning and memory. Several ... More


Excitatory Amino Acid Transmission and Synaptic Plasticity

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0011
Subject:
Neuroscience, Sensory and Motor Systems

Activity-dependent, long-lasting synaptic enhancement induced by neuronal stimulation, known as long-term potentiation (LTP), is not unique to the hippocampus; rather, it seems to be a fundamental ... More


 Spatial Learning and the Selectivity of Hippocampal Place Fields: Modulation by Dopamine

Kathryn M. Gill and Sheri J. Y. Mizumori

in Hippocampal Place Fields: Relevance to Learning and Memory

Published in print:
2008
Published Online:
May 2008
ISBN:
9780195323245
eISBN:
9780199869268
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195323245.003.0020
Subject:
Psychology, Cognitive Neuroscience

This chapter compares the putative mechanisms by which dopamine selectively affects learning that is thought to be mediated by functionally distinct brain regions, such as the hippocampus and dorsal ... More


Cellular Plasticity Mechanisms

Howard Eichenbaum and Neal J. Cohen

in From Conditioning to Conscious Recollection: Memory systems of the brain

Published in print:
2004
Published Online:
January 2008
ISBN:
9780195178043
eISBN:
9780199871223
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195178043.003.0003
Subject:
Psychology, Cognitive Psychology

This chapter reviews recent progress towards an understanding of synaptic plasticity resulting in increased synaptic efficacy as the main candidate for a cellular mechanism of memory. The most ... More


Excitatory Amino Acid Transmission in Health and Disease

Robert Balazs, Richard J. Bridges, and Carl W. Cotman

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.001.0001
Subject:
Neuroscience, Sensory and Motor Systems

This book provides a comprehensive, easy-to-read survey of excitatory amino acids and synaptic transmission. It begins with descriptions of the structure, function, and pharmacology of both the ... More


Parallel Properties of Long-Term Potentiation and Memory

Ursula V. Staubli

in Brain and Memory: Modulation and Mediation of Neuroplasticity

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195082944
eISBN:
9780199847877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082944.003.0018
Subject:
Psychology, Cognitive Neuroscience

The discovery of the long-term potentiation (LTP) effect is generally held to have been a major step forward in the search for the mechanisms of memory. LTP develops within seconds, is specific to ... More


Neurobiology Of Chronic Pain

Min Zhuo

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems

Understanding the neurobiology of sensory synapses in the central nervous system provides us with basic knowledge of physiological and pathological pain, and has the potential to reveal possible drug ... More


Metaplasticity: the plasticity of synaptic plasticity

Benjamin D. Philpot, Mark F. Bear, and Wickliffe C. Abraham

in Beyond Neurotransmission: Neuromodulation and its Importance for Information Processing

Published in print:
1999
Published Online:
March 2012
ISBN:
9780198524243
eISBN:
9780191724435
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198524243.003.0005
Subject:
Neuroscience, Behavioral Neuroscience

Activity-dependent modifications of synaptic efficacy are essential both for the developmental organization of the brain and for the storage of information. It is now well established that the ... More


Hippocampal Synaptic Enhancement as a Basis for Learning and Memory:: A Selected Review of Current Evidence from Behaving Animals

C. A. Barnes, C. A. Erickson, S. Davis, and B. L. McNaughton

in Brain and Memory: Modulation and Mediation of Neuroplasticity

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195082944
eISBN:
9780199847877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082944.003.0016
Subject:
Psychology, Cognitive Neuroscience

Since the discovery of long-term synaptic enhancement and long-term potentiation (LTE/LTP), a substantial body of empirical support has accumulated for the theory that LTP of hippocampal synapses ... More


Cellular Mechanisms of Memory: Complex Circuits

Howard Eichenbaum

in The Cognitive Neuroscience of Memory: An Introduction

Published in print:
2011
Published Online:
May 2012
ISBN:
9780199778614
eISBN:
9780199932962
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199778614.003.0003
Subject:
Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems

This chapter reviews some of the progress toward a full characterization of one particular form of synaptic plasticity observed in the mammalian brain called long-term potentiation (LTP). LTP is only ... More


On the Relevance of Long-Term Potentiation to Learning and Memory

Yadin Dudai

in Brain and Memory: Modulation and Mediation of Neuroplasticity

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195082944
eISBN:
9780199847877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082944.003.0019
Subject:
Psychology, Cognitive Neuroscience

Mechanisms that are recruited in long-term potentiation (LTP) may operate in certain types of learning. Research restricted to the molecular or cellular level cannot provide one with an answer to the ... More


Causal Relevance and Manipulation

Carl F. Craver

in Explaining the Brain

Published in print:
2007
Published Online:
January 2009
ISBN:
9780199299317
eISBN:
9780191715075
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299317.003.0003
Subject:
Philosophy, Philosophy of Mind, Philosophy of Science

This chapter presents a view of causal relevance that accommodates the mechanistic fragility and historical contingency of neuroscientific generalizations but that nonetheless satisfies constraints ... More


Terje Lømo

Larry R. Squire

in The History of Neuroscience in Autobiography: Volume 7

Published in print:
2011
Published Online:
January 2012
ISBN:
9780195396133
eISBN:
9780199918409
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195396133.003.0009
Subject:
Neuroscience, History of Neuroscience

Terje Lømo discovered long term potentiation (LTP) and with Tim Bliss did the first systematic study of LTP. Lømo discovered that evoked muscle impulse activity per se controlled the properties of ... More


Introduction

Edmund T. Rolls

in Memory, Attention, and Decision-Making: A Unifying Computational Neuroscience Approach

Published in print:
2007
Published Online:
September 2009
ISBN:
9780199232703
eISBN:
9780191724046
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199232703.003.0001
Subject:
Neuroscience, Behavioral Neuroscience

This introductory chapter discusses neurons, neurons in a network, synaptic modification, long-term potentiation and long-term depression, and distributed representations. It also details the fine ... More


Overview and Perspective

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0001
Subject:
Neuroscience, Sensory and Motor Systems

L-Glutamate (Glu) is the most prevalent neurotransmitter in the mammalian central nervous system (CNS) and is responsible for mediating the majority of its excitatory signaling. From the start, ... More


Is Long-Term Potentiation a Plausible Basis for Memory?

C. R. Gallistel

in Brain and Memory: Modulation and Mediation of Neuroplasticity

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195082944
eISBN:
9780199847877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082944.003.0020
Subject:
Psychology, Cognitive Neuroscience

This chapter focuses on properties that long-term potentiation (LTP) and memory have in common. The discovery of the cellular and molecular bases of memory is among the most important quests in ... More


Plasticity

Rafael Yuste

in Dendritic Spines

Published in print:
2010
Published Online:
August 2013
ISBN:
9780262013505
eISBN:
9780262259286
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262013505.003.0008
Subject:
Neuroscience, Research and Theory

The connection between spine plasticity and hippocampal long-term potentiation (LTP) is explored in this chapter. Data were gathered using ultrastructural and imaging studies. Findings revealed that ... More


Synaptic Plasticity in Hippocampus and Neocortex: A Comparison

Robert C. Malenka

in The Cortical Neuron

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195083309
eISBN:
9780199847464
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195083309.003.0007
Subject:
Neuroscience, Molecular and Cellular Systems

Over the last decade, long-term potentiation (LTP) in the hippocampus has been the most intensively studied model of activity-dependent synaptic plasticity in the mammalian brain primarily because it ... More


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