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Signal reception: Ligand-gated ion channel receptors

R. Wayne Davies and Thora A. Glencorse

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0008
Subject:
Neuroscience, Molecular and Cellular Systems

Fast synaptic transmission is crucial for real-time functioning of the brain. All the receptor molecules that mediate fast transmission events are also ligand-gated ion channels, i.e., they are ion ... More


Signal reception: G protein-coupled receptors

Jennifer A Koenig

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0009
Subject:
Neuroscience, Molecular and Cellular Systems

G protein-coupled receptors (GPCRs) transduce extracellular signals into a multitude of intracellular changes including changes in electrical activity, levels of second messengers, secretion, ... More


Structural Chemistry of Group 16 Elements

Wai-Kee Li, Gong-Du Zhou, and Thomas Chung Wai Mak

in Advanced Structural Inorganic Chemistry

Published in print:
2008
Published Online:
May 2008
ISBN:
9780199216949
eISBN:
9780191711992
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199216949.003.0016
Subject:
Physics, Crystallography: Physics

This chapter focuses on the first two elements of the group: oxygen and sulfur. There is a section each on dioxygen and ozone, oxygen and dioxygen coordination compounds, and structure of water and ... More


Ionotropic Glutamate Receptors: General Characteristics

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0002
Subject:
Neuroscience, Sensory and Motor Systems

Ionotropic glutamate receptors (iGluRs) are the principal mediators of fast excitatory transmission in the central nervous system. These receptors were originally distinguished by their specific ... More


Ion channels: Principles, terminology and methodology

Derek Trezise, Tim Dale, and Martin Main

in Ion Channels: From Structure to Function

Published in print:
2009
Published Online:
March 2012
ISBN:
9780199296750
eISBN:
9780191724572
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199296750.003.0001
Subject:
Neuroscience, Development

Ion channels are cellular proteins that conduct the movement of ions from one side of a membrane to the other. The resultant changes in local ion concentrations and electrical field play pivotal ... More


The detection and properties of electrogenic Na+–K+ transport in the squid axon membrane

U. Kishimoto, I. Inoue, I. Tsutsui, and T. Ohkawa

in Cephalopod Neurobiology: Neuroscience Studies in Squid, Octopus and Cuttlefish

Published in print:
1995
Published Online:
March 2012
ISBN:
9780198547907
eISBN:
9780191724299
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198547907.003.0036
Subject:
Neuroscience, Invertebrate Neurobiology

This chapter discusses the detection and properties of electronic Na+−K+ transport in the squid axon membrane. The Na pump in the plasma membrane of animal cells mediates uphill transport of Na+ and ... More


NMDA receptor agonists and competitive antagonists

MARK L. MAYER, MORRIS BENVENISTE, and DORIS K. PATNEAU

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0004
Subject:
Neuroscience, Molecular and Cellular Systems

NMDA receptors have a rich and diverse pharmacology reflecting the presence of multiple ligand binding sites at which agonists, antagonists, and modulators interact in an allosteric manner. This ... More


Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes

DANIEL T. MONAGHAN and AMY L. BULLER

in The NMDA Receptor

Published in print:
1995
Published Online:
March 2012
ISBN:
9780192625021
eISBN:
9780191724701
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192625021.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter compares the anatomical and pharmacological properties of the recombinant NMDA receptor subunits with the properties of native NMDA receptor subtypes. It first summarizes the anatomical ... More


5-HT3 receptor antagonists and their potential in psychiatric disorders

Michael G. Palfreyman, Stephen M. Sorensen, Albert A. Carr, Hsien C. Cheng, and Mark W. Dudley

in 5-Hydroxytryptamine in Psychiatry: A Spectrum of Ideas

Published in print:
1991
Published Online:
March 2012
ISBN:
9780192620118
eISBN:
9780191724725
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192620118.003.0023
Subject:
Neuroscience, Techniques

Classification of 5-hydroxytryptamine (5-HT, serotonin) receptors in the guinea pig ileum into ‘D’ receptors located on smooth muscle cells and those located on intramural cholinergic neurones of the ... More


Changing Partners: Complex Substitution

Peter Atkins

in Reactions: The private life of atoms

Published in print:
2011
Published Online:
November 2020
ISBN:
9780199695126
eISBN:
9780191918445
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199695126.003.0014
Subject:
Chemistry, Physical Chemistry

I shall now describe a special case of the Lewis acid–base reactions I introduced in Reaction 9. I showed there that a Lewis acid is a species that can accept a lone pair from another incoming ... More


Macromolecular conformations and interactions

Dennis Sherwood and Paul Dalby

in Modern Thermodynamics for Chemists and Biochemists

Published in print:
2018
Published Online:
August 2018
ISBN:
9780198782957
eISBN:
9780191826177
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198782957.003.0025
Subject:
Physics, Theoretical, Computational, and Statistical Physics

As a polymer of many amino acids, any given protein can, in principle, adopt a huge number of configurations. In reality, however, the biologically stable protein adopts a single configuration that ... More


Soil Adsorption Phenomena

Garrison Sposito

in The Chemistry of Soils

Published in print:
2016
Published Online:
November 2020
ISBN:
9780190630881
eISBN:
9780197559710
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190630881.003.0012
Subject:
Chemistry, Environmental Chemistry

Adsorption experiments involving soil particles typically are performed in a sequence of three steps: (1) reactio of an adsorptive (ion or molecule) with a soil contacting an aqueous solution of ... More


Charge Density Studies of Transition Metal Compounds

Philip Coppens

in X-Ray Charge Densities and Chemical Bonding

Published in print:
1997
Published Online:
November 2020
ISBN:
9780195098235
eISBN:
9780197560877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195098235.003.0012
Subject:
Chemistry, Physical Chemistry

The electron density in transition metal complexes is of unusual interest. The chemistry of transition metal compounds is of relevance for catalysis, for solid-state properties, and for a large ... More


Effects of High Pressure on the Allosteric Properties of Phosphofructokinase from Escherlchia coli

Jason L. Johnson and Gregory D. Reinhart

in High Pressure Effects in Molecular Biophysics and Enzymology

Published in print:
1996
Published Online:
November 2020
ISBN:
9780195097221
eISBN:
9780197560839
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195097221.003.0019
Subject:
Chemistry, Organic Chemistry

Phosphofructokinase (PFK) from Escherichia coli is subject to allosteric regulation by phosphoenolpyruvate (PEP) and MgADP. These ligands inhibit and activate, respectively, by binding to a single ... More


The Effects of Increased Viscosity on the Function of Integral Membrane Proteins

Suzanne F. Scarlata

in High Pressure Effects in Molecular Biophysics and Enzymology

Published in print:
1996
Published Online:
November 2020
ISBN:
9780195097221
eISBN:
9780197560839
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195097221.003.0024
Subject:
Chemistry, Organic Chemistry

For many years the idea that the activity of integral membrane proteins is regulated by the fluidity of the lipid matrix was popular and appeared to be quite rational. However, as information about ... More


Osmotic and Hydrostatic Pressure as Tools to Study Molecular Recognition

Stephen G. Sligar and Clifford R. Robinson

in High Pressure Effects in Molecular Biophysics and Enzymology

Published in print:
1996
Published Online:
November 2020
ISBN:
9780195097221
eISBN:
9780197560839
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195097221.003.0026
Subject:
Chemistry, Organic Chemistry

The question of molecular recognition is a central paradigm of molecular biology, playing central roles in most, if not all, cellular processes. Failed recognition events have been implicated in ... More


Pressure-Tuning Spectroscopy of Proteins: Fourier Transform Infrared Studies in the Diamond Anvil Cell

Karel Heremans and Koen Goossens

in High Pressure Effects in Molecular Biophysics and Enzymology

Published in print:
1996
Published Online:
November 2020
ISBN:
9780195097221
eISBN:
9780197560839
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195097221.003.0007
Subject:
Chemistry, Organic Chemistry

The effect of hydrostatic pressure on the secondary structure of proteins can be followed by Fourier transform infrared (FTIR) spectroscopy in the diamond anvil cell. Pressure-induced changes in ... More


Solvated Ions in Water

Bruce C. Bunker and William H. Casey

in The Aqueous Chemistry of Oxides

Published in print:
2016
Published Online:
November 2020
ISBN:
9780199384259
eISBN:
9780197562987
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199384259.003.0009
Subject:
Chemistry, Inorganic Chemistry

In most undergraduate chemistry classes, students are taught to consider reactions in which cations and anions dissolved in water are depicted as isolated ions. For example, the magnesium ion is ... More


The Chemistry of Extended Oxide Surfaces

Bruce C. Bunker and William H. Casey

in The Aqueous Chemistry of Oxides

Published in print:
2016
Published Online:
November 2020
ISBN:
9780199384259
eISBN:
9780197562987
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199384259.003.0011
Subject:
Chemistry, Inorganic Chemistry

In Chapters 4 and 5, we demonstrated that local structures and charge distributions have an enormous impact on the equilibrium constants, trajectories, and kinetics of reactions involving soluble ... More


Stopped-flow fluorescence spectroscopy

Michael G. Gore and Stephen P. Bottomley

in Spectrophotometry and Spectrofluorimetry: A Practical Approach

Published in print:
2000
Published Online:
November 2020
ISBN:
9780199638130
eISBN:
9780191918179
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199638130.003.0013
Subject:
Chemistry, Organic Chemistry

Biochemical reactions, such as substrate or coenzyme binding to enzymes are usually completed in no more than 50-100 ms and thus require rapid reaction techniques such as stopped-flow ... More


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