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Childhood leukemias

Anand P. Chokkalingam and Patricia A. Buffler

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0014
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The term “leukemia” refers broadly to cancer of the white blood cells, or leukocytes. As a group, leukemias are the most common cancer among people under 15 years of age, accounting for 32% of all ... More


The Leukemias

MARTHA S. LINET, SUSAN S. DEVESA, and GARETH J. MORGAN

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0044
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The leukemias arise from malignant transformation of hematopoietic stem or progenitor cells that originate in the bone marrow, lymph nodes, and/or other lymphoid tissue with immune function. A small ... More


Death and Dignity: A Case of Individualized Decision Making  

Timothy E. Quill

in Caring for Patients at the End of Life: Facing an Uncertain Future Together

Published in print:
2001
Published Online:
November 2011
ISBN:
9780195139402
eISBN:
9780199999859
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195139402.003.0004
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making, Palliative Medicine and Older People

This chapter relates a case of individualized decision making in a patient named Diane who was diagnosed with acute leukemia. In the author's conversation with Diane and her family about her ... More


Pediatric Oncology: A Medical Overview

David J. Bearison and Raymond K. Mulhern

in Pediatric Psychooncology: Psychological Perspectives on Children with Cancer

Published in print:
1994
Published Online:
November 2011
ISBN:
9780195079319
eISBN:
9780199999804
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195079319.003.0002
Subject:
Palliative Care, Paediatric Palliative Medicine, Patient Care and End-of-Life Decision Making

This chapter discusses the medical aspects of pediatric cancer, valuable to readers with little or no background in biomedical sciences and medical practice. It considers the etiology, clinical ... More


Neuropsychological Late Effects

David J. Bearison and Raymond K. Mulhern

in Pediatric Psychooncology: Psychological Perspectives on Children with Cancer

Published in print:
1994
Published Online:
November 2011
ISBN:
9780195079319
eISBN:
9780199999804
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195079319.003.0006
Subject:
Palliative Care, Paediatric Palliative Medicine, Patient Care and End-of-Life Decision Making

The dramatic improvements in treating childhood cancers also have occasioned a variety of treatment-related toxicities. None are more significant than neuropsychological late effects caused by ... More


Nuclear Energy and Environmental Justice

Kristin Shrader-Frechette

in What Will Work: Fighting Climate Change with Renewable Energy, Not Nuclear Power

Published in print:
2011
Published Online:
January 2012
ISBN:
9780199794638
eISBN:
9780199919277
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199794638.003.0005
Subject:
Philosophy, Moral Philosophy

Chapter 5 shows that, even when accidents are ignored, fission causes many serious pollution-induced health effects. In addition, atomic energy is ... More


Log-normal distribution—leukemia and pesticide exposure

Steve Selvin

in The Joy of Statistics: A Treasury of Elementary Statistical Tools and their Applications

Published in print:
2019
Published Online:
May 2019
ISBN:
9780198833444
eISBN:
9780191872280
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198833444.003.0040
Subject:
Mathematics, Probability / Statistics, Applied Mathematics

Like the normal distribution, the log-normal distribution’s properties are useful and often revealing. A short description presents an analysis of log-normal data collected to asses cancer risk ... More


Cancer Survival Is (Mostly) Improving

Michael D. Stein and Sandro Galea

in Pained: Uncomfortable Conversations about the Public's Health

Published in print:
2020
Published Online:
April 2020
ISBN:
9780197510384
eISBN:
9780197510414
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780197510384.003.0070
Subject:
Public Health and Epidemiology, Epidemiology, Public Health

This chapter discusses how the 5-year survival rates for the most common cancers in the United States improved by nearly 20% since the 1970s. While promising overall, low survival rates persist for ... More


Managing the Future at the Special Virus Leukemia Program

Robin Wolfe Scheffler

in A Contagious Cause: The American Hunt for Cancer Viruses and the Rise of Molecular Medicine

Published in print:
2019
Published Online:
January 2020
ISBN:
9780226458892
eISBN:
9780226628400
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226628400.003.0006
Subject:
History, History of Science, Technology, and Medicine

The changing political circumstances discussed in chapter 4 gave the National Cancer Institute unprecedented resources for biomedical research into cancer. However, this windfall also created ... More


The Drug Discovery Crisis

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0001
Subject:
Public Health and Epidemiology, Public Health

This chapter examines the current problem associated with creating new drugs—that so few proteins are considered druggable. It first traces the history of how existing drugs were created. It then ... More


A Landmark Clinical Trial

Peter Keating and Alberto Cambrosio

in Cancer on Trial: Oncology as a New Style of Practice

Published in print:
2012
Published Online:
September 2013
ISBN:
9780226428918
eISBN:
9780226428932
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226428932.003.0039
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the VAMP trial, the clinical trial to test a combination of anticancer drugs on children with acute lymphocytic leukemia (ALL). Four different drugs with different mechanisms ... More


Magic Bullets? The Gleevec Trials

Peter Keating and Alberto Cambrosio

in Cancer on Trial: Oncology as a New Style of Practice

Published in print:
2012
Published Online:
September 2013
ISBN:
9780226428918
eISBN:
9780226428932
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226428932.003.0144
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the series of clinical trials conducted between 1998 and 2001 to test the efficacy of a compound known as Gleevec. Gleevec (imatinib), one of the first targeted cancer ... More


Female Reproductive Function

Sergio R. Ojeda

in Textbook of Endocrine Physiology

Published in print:
2011
Published Online:
November 2020
ISBN:
9780199744121
eISBN:
9780197563045
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199744121.003.0011
Subject:
Clinical Medicine and Allied Health, Endocrinology and Diabetes

The production of germ cells is essential for the continuation of a species. In the female this function is accomplished by the ovaries. In addition, the ovaries secrete steroids and nonsteroidal ... More


Mechanisms of Hormone Action

Stephen R. Hammes and Carole R. Mendelson

in Textbook of Endocrine Physiology

Published in print:
2011
Published Online:
November 2020
ISBN:
9780199744121
eISBN:
9780197563045
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199744121.003.0006
Subject:
Clinical Medicine and Allied Health, Endocrinology and Diabetes

The capacity of a cell to respond to a particular hormone depends on the presence of cellular receptors specific for that hormone. After binding hormone, the receptor is biochemically and ... More


Dielectric Properties of Blood and Blood Components

Yoshihito Hayashi and Koji Asami

in Dielectric Relaxation in Biological Systems: Physical Principles, Methods, and Applications

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686513
eISBN:
9780191766398
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686513.003.0014
Subject:
Physics, Soft Matter / Biological Physics

An overview of dielectric spectroscopy (DS) studies for erythrocytes, blood coagulation, and leukocytes is provided. Cell suspensions and whole blood show the main dielectric response in the MHz ... More


Contested Medicine: Cancer Research and the Military

Gerald Kutcher

Published in print:
2009
Published Online:
March 2013
ISBN:
9780226465319
eISBN:
9780226465333
Item type:
book
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226465333.001.0001
Subject:
History, History of Science, Technology, and Medicine

In the 1960s, University of Cincinnati radiologist Eugene Saenger infamously conducted human experiments on patients with advanced cancer to examine how total body radiation could treat the disease. ... More


Military Medicine and Cancer Therapy

in Contested Medicine: Cancer Research and the Military

Published in print:
2009
Published Online:
March 2013
ISBN:
9780226465319
eISBN:
9780226465333
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226465333.003.0004
Subject:
History, History of Science, Technology, and Medicine

This chapter addresses the intimate relationship between research for cancer therapy and military medicine. It considers the efforts of Donnal Thomas from 1957 to 1977 and his development of a ... More


A Quiet Revolution: The Legacy of Monoclonal Antibodies

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0010
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses legacy of monoclonal antibodies (Mabs). Mab therapeutics are some of the best-selling drugs in the world today. As of 2012 there were over thirty Mab drugs on the world market. ... More


The Biomedical Settlement and the Federalization of the Cancer Problem

Robin Wolfe Scheffler

in A Contagious Cause: The American Hunt for Cancer Viruses and the Rise of Molecular Medicine

Published in print:
2019
Published Online:
January 2020
ISBN:
9780226458892
eISBN:
9780226628400
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226628400.003.0005
Subject:
History, History of Science, Technology, and Medicine

Although many assume that the federal government always had a leading role in anticancer efforts, it only gained this status in the middle of the 1950s. Chapter 4 explores how the government ... More


Radiation and Mutation

Soraya de Chadarevian

in Heredity under the Microscope: Chromosomes and the Study of the Human Genome

Published in print:
2020
Published Online:
January 2021
ISBN:
9780226685083
eISBN:
9780226685250
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226685250.003.0002
Subject:
History, History of Science, Technology, and Medicine

Chapter 1 substantiates the claim that atomic age anxieties were the driving force for a new interest in human chromosomes. By providing techniques to visualize mutations, karyotyping emerged as the ... More


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