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Stochastic Simulation of Neurons, Axons, and Action Potentials

A. Aldo Faisal

in Stochastic Methods in Neuroscience

Published in print:
2009
Published Online:
February 2010
ISBN:
9780199235070
eISBN:
9780191715778
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199235070.003.0011
Subject:
Mathematics, Biostatistics

Variability is inherent in neurons. To account for variability we have to make use of stochastic models. We will take a look at this biologically more rigorous approach by studying the fundamental ... More


Ion Channels and Regulation of Dopamine Neuron Activity

Birgit Liss and Jochen Roeper

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0009
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Ion channels are at the heart of generating electrical activity of neurons and coupling it to neurotransmitter release. They comprise a superfamily of transmembrane proteins that form pores through ... More


Ion channels and electrical activity

Mauro Pessia

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0005
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter describes the main structural determinants regulating the function of some voltage-gated Na+, K+, and Ca++ channels and their fundamental role in cell excitability. Voltage-dependent ... More


Ion channels: Principles, terminology and methodology

Derek Trezise, Tim Dale, and Martin Main

in Ion Channels: From Structure to Function

Published in print:
2009
Published Online:
March 2012
ISBN:
9780199296750
eISBN:
9780191724572
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199296750.003.0001
Subject:
Neuroscience, Development

Ion channels are cellular proteins that conduct the movement of ions from one side of a membrane to the other. The resultant changes in local ion concentrations and electrical field play pivotal ... More


Patch-Clamp Recording

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0002
Subject:
Psychology, Cognitive Neuroscience

Invented by Bert Sakmann and Erwin Neher during the 1970s, the patch-clamp recording technique aids scientists in examining the functions of individual protein molecules that form ion channels in ... More


Equations Underlying the Patch Model

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0017
Subject:
Psychology, Cognitive Neuroscience

The Patch model illustrates results obtained from patch-clamp experiments. This chapter describes the elementary equations for currents through individual ion channels, based on Ohm's law. Because ... More


Voltage-gated ion channels in axons: Localization, function, and development

STEPHEN G. WAXMAN

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0011
Subject:
Neuroscience, Disorders of the Nervous System

This chapter discusses the molecular architecture of the cell membrane of mammalian axons. It focuses on the distribution and development of voltage-gated ion channels, their roles in axonal ... More


Molecular biology of voltage-dependent potassium and sodium channels

ROBERT L. BARCHI

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0012
Subject:
Neuroscience, Disorders of the Nervous System

Excitation and conduction in axons depends on the time- and voltage-sensitive modulation of ionic conductances in the axon surface membrane. This chapter discusses the molecular biology of sodium and ... More


Markov Chain Models of Ion Channels and Calcium Release Sites

Jeffrey R. Groff, Hilary DeRemigio, and Gregory D. Smith

in Stochastic Methods in Neuroscience

Published in print:
2009
Published Online:
February 2010
ISBN:
9780199235070
eISBN:
9780191715778
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199235070.003.0002
Subject:
Mathematics, Biostatistics

This chapter is an introduction to modelling stochastically gating ion channels using continuous-time discrete-state Markov chains. Analytical and numerical methods are presented for determining ... More


Motoneurones: electrophysiology

Daniel Kernell

in The Motoneurone and its Muscle Fibres

Published in print:
2006
Published Online:
September 2009
ISBN:
9780198526551
eISBN:
9780191723896
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198526551.003.0006
Subject:
Neuroscience, Molecular and Cellular Systems

In the soma-dendrite region of a motoneurone, a spike is succeeded by a long-lasting afterhyperpolarization (AHP), which is important for the characteristics of maintained repetitive spike ... More


Signal reception: Ligand-gated ion channel receptors

R. Wayne Davies and Thora A. Glencorse

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0008
Subject:
Neuroscience, Molecular and Cellular Systems

Fast synaptic transmission is crucial for real-time functioning of the brain. All the receptor molecules that mediate fast transmission events are also ligand-gated ion channels, i.e., they are ion ... More


Ion Channels: From Structure to Function

James Kew and Ceri Davies (eds)

Published in print:
2009
Published Online:
March 2012
ISBN:
9780199296750
eISBN:
9780191724572
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199296750.001.0001
Subject:
Neuroscience, Development

Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent ... More


Bertil Hille

Larry R. Squire

in The History of Neuroscience in Autobiography: Volume 7

Published in print:
2011
Published Online:
January 2012
ISBN:
9780195396133
eISBN:
9780199918409
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195396133.003.0004
Subject:
Neuroscience, History of Neuroscience

Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na+ and K+ channels of axons can be distinguished by drugs such as ... More


Patch Model

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0009
Subject:
Psychology, Cognitive Neuroscience

The Patch model simulates the dynamics of a small piece of cell membrane as observed with the patch-clamp technique. Either individual channels in a small patch of membrane or the macroscopic current ... More


Ionotropic Glutamate Receptors: General Characteristics

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0002
Subject:
Neuroscience, Sensory and Motor Systems

Ionotropic glutamate receptors (iGluRs) are the principal mediators of fast excitatory transmission in the central nervous system. These receptors were originally distinguished by their specific ... More


The inside story: subcellular mechanisms of neuromodulation

Elizabeth A. Jonas and Leonard K. Kaczmarek

in Beyond Neurotransmission: Neuromodulation and its Importance for Information Processing

Published in print:
1999
Published Online:
March 2012
ISBN:
9780198524243
eISBN:
9780191724435
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198524243.003.0003
Subject:
Neuroscience, Behavioral Neuroscience

The processes within a neuron that are subject to modulation include changes in amplitude or kinetics of the ion channels, the insertion or removal of ion channel proteins from the membrane, changes ... More


Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels

Stephen J. Moss and Jeremy Henley (eds)

Published in print:
2002
Published Online:
March 2012
ISBN:
9780192632241
eISBN:
9780191724763
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192632241.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems

This book reviews the recent advances in understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting, and anchoring of the protein complexes making up the ... More


Dendritic voltage-gated ion channels

Jeffrey C. Magee

in Dendrites

Published in print:
2007
Published Online:
March 2012
ISBN:
9780198566564
eISBN:
9780191724206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566564.003.0009
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter focuses on the types and distributions of the main voltage-gated ion channels presently known to exist within the dendrites of CA1 pyramidal neurons, neocortical layer Vm pyramidal ... More


Metabotropic Glutamate Receptors

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0007
Subject:
Neuroscience, Sensory and Motor Systems

Metabotropic glutamate receptors (mGluRs) are a distinct family of excitatory amino acid receptors. Unlike the ionotropic glutamate receptors (iGluRs), which constitute cation-specific ion channels ... More


The assembly and targeting of potassium channels

Andrew Tinker

in Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels

Published in print:
2002
Published Online:
March 2012
ISBN:
9780192632241
eISBN:
9780191724763
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192632241.003.0002
Subject:
Neuroscience, Molecular and Cellular Systems

Potassium channels are one of the largest ion channel gene families. They are present in nearly all living organisms from bacteria through to man. There are a number of separate families of ... More


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