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Cytochrome P450 testing in the treatment of depression

Iris Grossman, Mugdha Thakur, and David B. Matchar

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0030
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter reviews studies on the use of CYP450 genotyping as a guide to the management of serotonin reuptake inhibitors (SSRIs) for patients with depression. Comparison of the results of available ... More


Toxic Gas in the Cockpit: Pro Form and National Insurance Company v. The Garrett Corporation

Roger W. Shuy

in Fighting over Words: Language and Civil Law Cases

Published in print:
2008
Published Online:
May 2008
ISBN:
9780195328837
eISBN:
9780199870165
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328837.003.0012
Subject:
Linguistics, Sociolinguistics / Anthropological Linguistics

The fatal crash of a private plane led to a lawsuit brought by the insurer against the manufacturer of the aircraft's engine. Investigators found no evidence of engine malfunction, so the insurer ... More


Pharmacology

B S K Kamath and Sarah Turle

in MCQs for the Primary FRCA

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199575770
eISBN:
9780191917899
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199575770.003.0008
Subject:
Clinical Medicine and Allied Health, Professional Development in Medicine


Heart Failure—Optimal Pharmacological Therapy

J.Paul Rocchiccioli and John J. V. Mcmurray

in Supportive Care in Heart Failure

Published in print:
2008
Published Online:
November 2011
ISBN:
9780198570288
eISBN:
9780191730030
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198570288.003.0004
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology

This chapter addresses the state of knowledge in the evidence-based management of heart failure (HF) with medications. Diuretics were amongst the first therapies to be used in the treatment of HF. ... More


Are There Medications for Slowing Disease Progression?

J. Eric Ahlskog

in Dementia with Lewy Body and Parkinson's Disease Patients: Patient, Family, and Clinician Working Together for Better Outcomes

Published in print:
2013
Published Online:
November 2020
ISBN:
9780199977567
eISBN:
9780197563342
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199977567.003.0007
Subject:
Clinical Medicine and Allied Health, Neurology

If diagnosed with dementia with Lewy bodies (DLB) or Parkinson’s disease, one would naturally want to do everything possible to halt or at least slow the disease progression. Are there medications ... More


Music: Where Cognition and Emotion Meet

John Sloboda

in Exploring the Musical Mind: Cognition, emotion, ability, function

Published in print:
2004
Published Online:
March 2012
ISBN:
9780198530121
eISBN:
9780191689741
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198530121.003.0019
Subject:
Psychology, Music Psychology

Music has all the characteristics which would lead one to predict that many people should be highly skilled at it. A long tradition of research into skill and its acquisition suggests that structure ... More


Prader-Willi Syndrome

Jennifer Zarcone and Sarah Spencer Welsh

in Cognitive and Behavioral Abnormalities of Pediatric Diseases

Published in print:
2010
Published Online:
November 2020
ISBN:
9780195342680
eISBN:
9780197562598
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195342680.003.0027
Subject:
Clinical Medicine and Allied Health, Psychiatry

Prader-Willi syndrome (PWS) is the most common genetic cause of obesity and the first identified genetic imprinting syndrome. Prader-Willi syndrome is caused by the lack of paternally expressed ... More


Neurologic Aspects of the Smith-Magenis Syndrome

Andrea L. Gropman and Ann C. M. Smith

in Cognitive and Behavioral Abnormalities of Pediatric Diseases

Published in print:
2010
Published Online:
November 2020
ISBN:
9780195342680
eISBN:
9780197562598
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195342680.003.0028
Subject:
Clinical Medicine and Allied Health, Psychiatry

The Smith-Magenis syndrome (SMS) is a multiple congenital anomaly and mental retardation syndrome (Greenberg et al. 1996). The clinical phenotype includes distinctive craniofacial and skeletal ... More


Factor Xa Inhibitors

Richard C. Becker and Frederick A. Spencer

in Fibrinolytic and Antithrombotic Therapy: Theory, Practice, and Management

Published in print:
2006
Published Online:
November 2020
ISBN:
9780195155648
eISBN:
9780197561959
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195155648.003.0021
Subject:
Clinical Medicine and Allied Health, Cardiovascular Medicine

The importance of factor Xa in the initiation and propagation of coagulation, as well as its pluripotential cellular properties, has been discussed previously. Considered collectively, the effects ... More


Parkinsonism Treatment for Those Already on Medications

J. Eric Ahlskog

in Dementia with Lewy Body and Parkinson's Disease Patients: Patient, Family, and Clinician Working Together for Better Outcomes

Published in print:
2013
Published Online:
November 2020
ISBN:
9780199977567
eISBN:
9780197563342
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199977567.003.0013
Subject:
Clinical Medicine and Allied Health, Neurology

The previous chapter provided instructions for starting and adjusting carbidopa/levodopa, but specifically pertained to those individuals on no other drugs for parkinsonism or those on only a low ... More


The Nature of Interactions Between Proteins

Brent R. Stockwell

in The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231152136
eISBN:
9780231525527
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231152136.003.0008
Subject:
Public Health and Epidemiology, Public Health

This chapter examines the nature of interactions between proteins and how proteins function in the cell. Many proteins that control disease processes but are considered undruggable are not enzymes. ... More


Becoming the AIDS Scribe

Andrew E. Stoner

in The Journalist of Castro Street: The Life of Randy Shilts

Published in print:
2019
Published Online:
January 2020
ISBN:
9780252042485
eISBN:
9780252051326
Item type:
chapter
Publisher:
University of Illinois Press
DOI:
10.5622/illinois/9780252042485.003.0007
Subject:
Society and Culture, Gay and Lesbian Studies

Shilts joins The San Francisco Chronicle as its first openly gay reporter on the newsroom staff. Hired to cover the “gay beat” in San Francisco, Shilts also is given general assignment stories. ... More


Hallelujah Moments: Tales of Drug Discovery

Eugene H. Cordes

Published in print:
2020
Published Online:
May 2021
ISBN:
9780190080457
eISBN:
9780190080488
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190080457.001.0001
Subject:
Chemistry, Medicinal Chemistry

This work provides eleven stories of drug discovery and features the scientists who made them. The outcome of the discovery work has provided novel therapies in cancer, cardiovascular medicine, ... More


Multiple Sclerosis

Adam I. Kaplin and Katherine A.L. Carroll

in Psychiatric Aspects of Neurologic Diseases: Practical approaches to patient care

Published in print:
2008
Published Online:
November 2020
ISBN:
9780195309430
eISBN:
9780197562451
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195309430.003.0013
Subject:
Clinical Medicine and Allied Health, Psychiatry

Multiple sclerosis (MS) is characterized by demyelination, axonal injury, inflammation, and gliosis (scarring) and can involve the brain, spinal cord, and optic nerves. The course of MS is ... More


Antidepressants

John R. Lipsey

in Psychiatric Aspects of Neurologic Diseases: Practical approaches to patient care

Published in print:
2008
Published Online:
November 2020
ISBN:
9780195309430
eISBN:
9780197562451
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195309430.003.0023
Subject:
Clinical Medicine and Allied Health, Psychiatry

Antidepressant drug therapy is the cornerstone of treatment for major depression and is usually successful (Rosenbaum et al., 2005). Fifty percent of patients respond to the first antidepressant ... More


Cholinesterase Inhibitors and Memantine

Constantine G. Lyketsos

in Psychiatric Aspects of Neurologic Diseases: Practical approaches to patient care

Published in print:
2008
Published Online:
November 2020
ISBN:
9780195309430
eISBN:
9780197562451
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195309430.003.0028
Subject:
Clinical Medicine and Allied Health, Psychiatry

Several lines of evidence suggest that acetylcholine (ACh) neurotransmission is important to the normal functioning of memory, and loss of ACh-producing cells in the basal forebrain (nucleus ... More


Dementia: Impaired Thinking and Judgment; Confusion

J. Eric Ahlskog

in Dementia with Lewy Body and Parkinson's Disease Patients: Patient, Family, and Clinician Working Together for Better Outcomes

Published in print:
2013
Published Online:
November 2020
ISBN:
9780199977567
eISBN:
9780197563342
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199977567.003.0020
Subject:
Clinical Medicine and Allied Health, Neurology

Dementia implies problems with cognition (thinking), and this is a fundamental component of DLB and PDD. Dementia also implies that the cognitive problems are sufficiently troublesome to affect ... More


Bladder Problems

J. Eric Ahlskog

in Dementia with Lewy Body and Parkinson's Disease Patients: Patient, Family, and Clinician Working Together for Better Outcomes

Published in print:
2013
Published Online:
November 2020
ISBN:
9780199977567
eISBN:
9780197563342
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199977567.003.0023
Subject:
Clinical Medicine and Allied Health, Neurology

Urinary problems occur with normal aging. In women they often relate to the changes in female anatomy due to the delivering of babies. With superimposed age-related changes in soft tissues, laxity ... More


Structure and responsiveness

Peter Grindrod CBE

in Mathematical Underpinnings of Analytics: Theory and Applications

Published in print:
2014
Published Online:
March 2015
ISBN:
9780198725091
eISBN:
9780191792526
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198725091.003.0004
Subject:
Mathematics, Analysis, Probability / Statistics

This chapter considers what dynamical models might tell about what has and has not been observed. This includes dynamics of opinions and social contacts which are time dependent and fully coupled. It ... More


Inducible defences and the jasmonate pathway

Edward E. Farmer

in Leaf Defence

Published in print:
2014
Published Online:
May 2014
ISBN:
9780199671441
eISBN:
9780191779626
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199671441.003.0005
Subject:
Biology, Plant Sciences and Forestry

Leaf defences are often inducible and frequently aimed at depleting energy and essential nutrients in herbivores. The nature of several inducible defence proteins including proteinase inhibitors and ... More


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