Nancy Rothwell and Sarah Loddick (eds)
- Published in print:
- 2002
- Published Online:
- March 2012
- ISBN:
- 9780198509806
- eISBN:
- 9780191724596
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198509806.001.0001
- Subject:
- Neuroscience, Disorders of the Nervous System
This new edition covers advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and mechanisms ...
More
This new edition covers advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and mechanisms involved to intervene in, and arrest, neurodegenerative disease processes. This book covers developmental aspects of immune/inflammatory responses in the central nervous system (CNS), basic aspects of glial function, as well as inflammatory mediators, their mechanisms of action, clinical importance, and sites of infection. There is also coverage of the major diseases of the CNS, including stroke, brain injury, multiple sclerosis, and Alzheimer's disease. Throughout, the focus is on the underlying basic neuroscience, clinical relevance, and the potential for therapeutic interventions. The book will be useful for improving the diagnosis of neuroimmune diseases and determining therapeutic measures.Less
This new edition covers advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and mechanisms involved to intervene in, and arrest, neurodegenerative disease processes. This book covers developmental aspects of immune/inflammatory responses in the central nervous system (CNS), basic aspects of glial function, as well as inflammatory mediators, their mechanisms of action, clinical importance, and sites of infection. There is also coverage of the major diseases of the CNS, including stroke, brain injury, multiple sclerosis, and Alzheimer's disease. Throughout, the focus is on the underlying basic neuroscience, clinical relevance, and the potential for therapeutic interventions. The book will be useful for improving the diagnosis of neuroimmune diseases and determining therapeutic measures.
Nancy J. Rothwell (ed.)
- Published in print:
- 1997
- Published Online:
- March 2012
- ISBN:
- 9781872748795
- eISBN:
- 9780191724381
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9781872748795.001.0001
- Subject:
- Neuroscience, Disorders of the Nervous System
This new edition covers recent advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and ...
More
This new edition covers recent advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and mechanisms involved to intervene in, and arrest, neurodegenerative disease processes. This book covers developmental aspects of immune/inflammatory responses in the CNS and basic aspects of glial function, as well as inflammatory mediators and their mechanisms of action, clinical importance, and sites of infection. There is also coverage of the major diseases of the CNS, including stroke, brain injury, multiple sclerosis, and Alzheimer's disease. Throughout, the focus is on the underlying basic neuroscience, clinical relevance and the potential for therapeutic interventions. This book aims to contribute to the understanding and improving of the diagnosis of neuroimmune diseases and determining therapeutic measures.Less
This new edition covers recent advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and mechanisms involved to intervene in, and arrest, neurodegenerative disease processes. This book covers developmental aspects of immune/inflammatory responses in the CNS and basic aspects of glial function, as well as inflammatory mediators and their mechanisms of action, clinical importance, and sites of infection. There is also coverage of the major diseases of the CNS, including stroke, brain injury, multiple sclerosis, and Alzheimer's disease. Throughout, the focus is on the underlying basic neuroscience, clinical relevance and the potential for therapeutic interventions. This book aims to contribute to the understanding and improving of the diagnosis of neuroimmune diseases and determining therapeutic measures.
Daniel C. Anthony and Sandra J. Campbell
- Published in print:
- 2002
- Published Online:
- March 2012
- ISBN:
- 9780198509806
- eISBN:
- 9780191724596
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198509806.003.0001
- Subject:
- Neuroscience, Disorders of the Nervous System
This chapter examines the influence of development on the inflammatory response in the central nervous system (CNS). It analyses the influence of the blood–brain barrier on brain inflammation, the ...
More
This chapter examines the influence of development on the inflammatory response in the central nervous system (CNS). It analyses the influence of the blood–brain barrier on brain inflammation, the leucocytes in the CNS, and the refractory nature of the brain. The findings suggest that while leucocyte traffic into the normal brain takes place as part of normal physiology, it is clear that the brain has evolved mechanisms to restrict the acute inflammatory response.Less
This chapter examines the influence of development on the inflammatory response in the central nervous system (CNS). It analyses the influence of the blood–brain barrier on brain inflammation, the leucocytes in the CNS, and the refractory nature of the brain. The findings suggest that while leucocyte traffic into the normal brain takes place as part of normal physiology, it is clear that the brain has evolved mechanisms to restrict the acute inflammatory response.
Maria-Cristina Morganti-Kossmann, Mario Rancan, Philip F. Stahel, and Thomas Kossmann
- Published in print:
- 2002
- Published Online:
- March 2012
- ISBN:
- 9780198509806
- eISBN:
- 9780191724596
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198509806.003.0008
- Subject:
- Neuroscience, Disorders of the Nervous System
This chapter presents an overview of the major developments in the study of inflammatory responses to traumatic brain injury (TBI), reviewing the controversial role of inflammatory responses after ...
More
This chapter presents an overview of the major developments in the study of inflammatory responses to traumatic brain injury (TBI), reviewing the controversial role of inflammatory responses after TBI resulting from clinical and experimental studies. It analyses the interaction of immune-competent cells of the central nervous system with the systemic immune system and discusses the controversy of the protective versus the deleterious consequences of immunoactivation.Less
This chapter presents an overview of the major developments in the study of inflammatory responses to traumatic brain injury (TBI), reviewing the controversial role of inflammatory responses after TBI resulting from clinical and experimental studies. It analyses the interaction of immune-competent cells of the central nervous system with the systemic immune system and discusses the controversy of the protective versus the deleterious consequences of immunoactivation.
