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Segmental duplications and indel polymorphisms

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0006
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

In this chapter the theme of structural genomic variation is continued with a particular focus on segmental duplications. The origins and extent of segmental duplications in humans and other species ... More


Sequence Evolution Models for Simultaneous Alignment and Phylogeny Reconstruction

Dirk Metzler and Roland Fleissner

in Sequence Alignment: Methods, Models, Concepts, and Strategies

Published in print:
2009
Published Online:
March 2012
ISBN:
9780520256972
eISBN:
9780520943742
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520256972.003.0005
Subject:
Biology, Evolutionary Biology / Genetics

This chapter reviews the statistical approaches for simultaneous alignment and phylogeny reconstruction. It focuses on the modeling of insertion and deletion events in a phylogenetic framework, and ... More


The origins of molecular diversity

Asher D. Cutter

in A Primer of Molecular Population Genetics

Published in print:
2019
Published Online:
August 2019
ISBN:
9780198838944
eISBN:
9780191874826
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198838944.003.0002
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

At its simplest, evolution is change in the relative abundance of alternative alleles, from one generation to the next. But where do these different alleles come from? As the ultimate origin of all ... More


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