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In Defense of Self: How the Immune System Really Works

William R. Clark

Published in print:
2008
Published Online:
September 2008
ISBN:
9780195336634
eISBN:
9780199868568
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195336634.001.0001
Subject:
Biology, Disease Ecology / Epidemiology

The immune system is the only thing standing between us and a world of microbial predators that could send us to an early and ugly death. It would be our only defense during the first hours of a ... More


When the Immune System Is the Problem, Not the Solution: Microbial Immunopathology

William R. Clark

in In Defense of Self: How the Immune System Really Works

Published in print:
2008
Published Online:
September 2008
ISBN:
9780195336634
eISBN:
9780199868568
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195336634.003.0006
Subject:
Biology, Disease Ecology / Epidemiology

The immune response to microbal infection is massive and brutal — it has to be. But on occasion, particularly when an initial infection is not rapidly cleared, the ongoing immune attack against ... More


Infection and pathogenesis

Paul Schmid-Hempel

in Evolutionary Parasitology: The Integrated Study of Infections, Immunology, Ecology, and Genetics

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199229482
eISBN:
9780191774744
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199229482.003.0009
Subject:
Biology, Disease Ecology / Epidemiology, Evolutionary Biology / Genetics

This chapter examines and discusses infection and pathogenesis – which is the physiological process underlying the development of virulence (the capability of a microorganism to cause disease) in the ... More


Ecological immunology

Paul Schmid-Hempel

in Evolutionary Parasitology: The Integrated Study of Infections, Immunology, Ecology, and Genetics

Published in print:
2021
Published Online:
September 2021
ISBN:
9780198832140
eISBN:
9780191870873
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198832140.003.0005
Subject:
Biology, Disease Ecology / Epidemiology, Evolutionary Biology / Genetics

Infections and parasite loads vary among hosts. Variation results from ecological, genetic, and immunological factors. Immune defences provide benefits as well as costs and are, therefore, a ... More


Transmission, infection, and pathogenesis

Paul Schmid-Hempel

in Evolutionary Parasitology: The Integrated Study of Infections, Immunology, Ecology, and Genetics

Published in print:
2021
Published Online:
September 2021
ISBN:
9780198832140
eISBN:
9780191870873
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198832140.003.0009
Subject:
Biology, Disease Ecology / Epidemiology, Evolutionary Biology / Genetics

Transmission is a key process for parasites. Different routes (e.g. faecal–oral) and modes (e.g. by aerosols or vectors) exist. A major context is vertical (to offspring) or horizontal (all other) ... More


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