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A classification of peripheral analgesics based upon their mode of action

Sérgio H. Ferreira

in Migraine: A Spectrum of Ideas

Published in print:
1990
Published Online:
March 2012
ISBN:
9780192618108
eISBN:
9780191724305
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192618108.003.0006
Subject:
Neuroscience, Disorders of the Nervous System

This chapter aims to discuss current ideas about the mechanism of action of peripheral analgesics, and to provide a rational basis both for their therapeutic use and for the development of new drugs. ... More


Chemical excitation and sensitization in nociceptors

Kress Michaela and Reeh Peter W.

in Neurobiology of Nociceptors

Published in print:
1996
Published Online:
March 2012
ISBN:
9780198523345
eISBN:
9780191724527
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523345.003.0011
Subject:
Neuroscience, Sensory and Motor Systems

From early psychophysical studies a variety of exogenous and endogenous substances have been found to induce pain and hyperalgesia, that is, to be algogenic. To study the underlying mechanisms ... More


Functional properties of human cutaneous nociceptors and their role in pain and hyperalgesia

TorebjÖrk H.E., Schmelz M., and Handwerker H.O.

in Neurobiology of Nociceptors

Published in print:
1996
Published Online:
March 2012
ISBN:
9780198523345
eISBN:
9780191724527
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523345.003.0014
Subject:
Neuroscience, Sensory and Motor Systems

The study of peripheral mechanisms of pain was greatly advanced by the technique of microneurography. This technique not only makes possible experiments on human volunteers instead of on guinea-pigs, ... More


Neural mechanisms of primary hyperalgesia

Meyer Richard A., Raja Srinivasa N., and Campbell James N.

in Neurobiology of Nociceptors

Published in print:
1996
Published Online:
March 2012
ISBN:
9780198523345
eISBN:
9780191724527
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523345.003.0015
Subject:
Neuroscience, Sensory and Motor Systems

Hyperalgesia is a consistent characteristic of tissue injury and inflammation. Pharyngitis is associated with hyperalgesia in the pharyngeal tissues, such that merely swallowing induces pain. In ... More


Secondary cutaneous dysaesthesiae

Lamotte Robert H.

in Neurobiology of Nociceptors

Published in print:
1996
Published Online:
March 2012
ISBN:
9780198523345
eISBN:
9780191724527
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523345.003.0016
Subject:
Neuroscience, Sensory and Motor Systems

A localized irritation of the skin, if sufficiently potent, produces a remarkable change in the quality of mechanically evoked sensations in a large area surrounding the injury. In the case of a ... More


Cutaneous nociceptors

Campbell James N. and Meyer Richard A.

in Neurobiology of Nociceptors

Published in print:
1996
Published Online:
March 2012
ISBN:
9780198523345
eISBN:
9780191724527
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523345.003.0005
Subject:
Neuroscience, Sensory and Motor Systems

The cutaneous nociceptor, the subject of this chapter, has been the centrepiece of research on peripheral nociceptive mechanisms. This is for three reasons: it is relatively easy to apply ... More


Headaches and Chronic Pain

Michael R. Clark

in Psychiatric Aspects of Neurologic Diseases: Practical approaches to patient care

Published in print:
2008
Published Online:
November 2020
ISBN:
9780195309430
eISBN:
9780197562451
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195309430.003.0012
Subject:
Clinical Medicine and Allied Health, Psychiatry

Pain has been defined as ‘‘an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage’’ (Lindblom et al., 1986). Table ... More


Opioids overview

Pippa Hawley

in Palliative Medicine: A Case-Based Manual

Published in print:
2021
Published Online:
January 2022
ISBN:
9780198837008
eISBN:
9780191873874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198837008.003.0002
Subject:
Palliative Care, Palliative Medicine and Older People

This chapter describes and discusses the World Health Organization Cancer’s pain ladder, including modifications to reflect current practice, specifically the limited role for Step 2, and the need to ... More


Pain

Fabrizio Benedetti

in Placebo Effects

Published in print:
2020
Published Online:
October 2021
ISBN:
9780198843177
eISBN:
9780191879067
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198843177.003.0010
Subject:
Neuroscience, Techniques

This chapter is dedicated to pain and analgesia, the area where most of the knowledge about the mechanisms of the placebo effect comes from. Expectation of pain reduction plays a crucial role in ... More


What are the Regional and Localized Forms of Fibromyalgia?

Daniel J. Wallace and Janice Brock Wallace

in All About Fibromyalgia: A Guide for Patients and their Families

Published in print:
2002
Published Online:
November 2020
ISBN:
9780195147537
eISBN:
9780197561843
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195147537.003.0020
Subject:
Clinical Medicine and Allied Health, Rheumatology

The definition of fibromyalgia includes widespread pain in all four quadrants (areas) of the body. What happens when you have fibromyalgia-like pain located in only one or two quadrants of the ... More


Z-axis and the Tombstone

Jonathan Cole

in Losing Touch: A man without his body

Published in print:
2016
Published Online:
August 2016
ISBN:
9780198778875
eISBN:
9780191834608
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198778875.003.0003
Subject:
Psychology, Cognitive Neuroscience, Neuropsychology

This chapter begins with Ian’s first foreign research trip, to Germany. His memories of the trip are extraordinary; even 30 years later they are of the moves he made and the nature of the built ... More


Managing Pain

Nick Allcock and Ruth Day

in Adult Nursing Practice: Using evidence in care

Published in print:
2012
Published Online:
November 2020
ISBN:
9780199697410
eISBN:
9780191918476
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199697410.003.0036
Subject:
Clinical Medicine and Allied Health, Nursing

This chapter aims to provide you with the knowledge to be able to take an evidence-based approach to the nursing management of people who are experiencing pain. As a practising nurse, pain will be ... More


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