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Reticulate evolution of disease vectors and diseases

Michael L. Arnold

in Reticulate Evolution and Humans: Origins and Ecology

Published in print:
2008
Published Online:
January 2009
ISBN:
9780199539581
eISBN:
9780191716225
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199539581.003.0008
Subject:
Biology, Animal Biology, Evolutionary Biology / Genetics

A goal shared by this chapter with all the other parts of this book is to emphasize the ubiquity of reticulate evolution as an agent of genetic and evolutionary change. Another goal, unique to the ... More


Genetic basis of human neuronal diseases

Mark E. S. Bailey

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter summarizes what is known about the genes underlying a range of human diseases where the causative or associated gene is expressed in neurons and there is a clear primary effect on ... More


Osteoporosis

André G. Uitterlinden, Joyce B. J. van Meurs, and Fernando Rivadeneira

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0017
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses gene-disease associations in osteoporosis. Osteoporosis is — together with osteoarthritis — the most common locomotor disease, and its clinical sequela, including fractures, ... More


Coronary heart disease

Adam S. Butterworth, Julian P. T. Higgins, Nadeem Sarwar, and John Danesh

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0019
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Coronary heart disease (CHD) — which includes myocardial infarction, angina pectoris, and stenosis of the coronary arteries — is the leading cause of death worldwide, with over 7 million deaths per ... More


Childhood leukemias

Anand P. Chokkalingam and Patricia A. Buffler

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0014
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The term “leukemia” refers broadly to cancer of the white blood cells, or leukocytes. As a group, leukemias are the most common cancer among people under 15 years of age, accounting for 32% of all ... More


Bladder cancer

Jonine D. Figueroa, Montserrat Garcia-Closas, and Nathaniel Rothman

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0015
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

A literature search was performed using the HuGE Navigator with the term “bladder cancer” and PubMed searches with the terms “ bladder cancer polymorphisms” and “bladder cancer risk variants” through ... More


Schizophrenia

Lars Bertram

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0020
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Efforts to identify the genes that modulate the risk for schizophrenia (SZ) have met with only limited success. This is at least in part due to problems that aggravate epidemiologic research in many ... More


Colorectal cancer

Harry Campbell, Steven Hawken, Evropi Theodoratou, Alex Demarsh, Kimberley Hutchings, Candice Y. Johnson, Lindsey Masson, Linda Sharp, Valerie Tait, and Julian Little

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0013
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Inherited genetic factors play an important role in the etiology of colorectal cancer. Rare high-penetrance mutations account for a small proportion of diseases but their identification plays an ... More


Preterm birth

Siobhan M. Dolan

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0018
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Preterm birth (PTB) is a perplexing clinical condition and major public health challenge. In 2006, 12.8% of all births in the United States were preterm, defined as occurring before 37 completed ... More


Type 2 diabetes

Eleftheria Zeggini and Mark I. McCarthy

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0016
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses the genetics of type 2 diabetes (T2D). T2D represents one of the most important causes of global morbidity and mortality. On current projections, the prevalence of this ... More


Statistical Analysis of Epidemiologic Data

Steve Selvin

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195172805
eISBN:
9780199865697
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195172805.001.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Analytic procedures suitable for the study of human disease are scattered throughout the statistical and epidemiologic literature. Explanations of their properties are frequently presented in ... More


The Evolutionary Basis for Animal Research

Stephen P. Schiffer

in The Ethics of Animal Research: Exploring the Controversy

Published in print:
2012
Published Online:
August 2013
ISBN:
9780262017060
eISBN:
9780262301602
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262017060.003.0003
Subject:
Biology, Bioethics

This chapter reports that there is clear public support for ethically guided animal research and seeks to articulate a scientific basis for this intuition using the theory of evolution. It states ... More


Disease and Its Treatment

Lawrence E. Hunter

in The Processes of Life: An Introduction to Molecular Biology

Published in print:
2009
Published Online:
August 2013
ISBN:
9780262013055
eISBN:
9780262255288
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262013055.003.0009
Subject:
Biology, Biochemistry / Molecular Biology

This chapter explores the fundamentals of human disease and its treatment. It begins with a discussion on the general principles of pathology and therapeutics. It then examines healing in organisms, ... More


Introduction

Guenter B. Risse

in Driven by Fear: Epidemics and Isolation in San Francisco's House of Pestilence

Published in print:
2015
Published Online:
April 2017
ISBN:
9780252039843
eISBN:
9780252097959
Item type:
chapter
Publisher:
University of Illinois Press
DOI:
10.5406/illinois/9780252039843.003.0001
Subject:
History, Social History

This introductory chapter lays out the major themes and context that will supplement discussion in the succeeding chapters. It considers the implications of the linkages between health and politics ... More


Epilogue

Sheldon Krimsky

in Stem Cell Dialogues: A Philosophical and Scientific Inquiry Into Medical Frontiers

Published in print:
2015
Published Online:
November 2015
ISBN:
9780231167482
eISBN:
9780231539401
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231167482.003.0026
Subject:
Biology, Bioethics

This book has explored the science and ethics behind stem cells, as well as the excitement and optimism within the scientific community about the role stem cells would someday play in treating human ... More


Why is this Cell Different from Other Cells?

Sheldon Krimsky

in Stem Cell Dialogues: A Philosophical and Scientific Inquiry Into Medical Frontiers

Published in print:
2015
Published Online:
November 2015
ISBN:
9780231167482
eISBN:
9780231539401
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231167482.003.0002
Subject:
Biology, Bioethics

In this dialogue, Dr. Charles Walker, a stem cell biologist, and Dr. Rebecca Franklin are having a conversation about how stem cells differ from other cells. Walker is one of the nation's pioneers in ... More


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