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Hippocampus and Human Disease

Walker Matthew, Chan Dennis, and Thom Maria

in The Hippocampus Book

Published in print:
2006
Published Online:
May 2009
ISBN:
9780195100273
eISBN:
9780199864133
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195100273.003.0016
Subject:
Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience

This chapter focuses on two disorders in which the role of the hippocampus has been extensively investigated: Alzheimer's disease and temporal lobe epilepsy. Although in Alzheimer's disease the ... More


Neurodevelopmental Disorders

Alexander Prehn-Kristensen, Richard Cooke, Lioba Baving, and Cynthia Schumann

in The Clinical Neurobiology of the Hippocampus: An integrative view

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199592388
eISBN:
9780199949922
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199592388.003.0010
Subject:
Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience

Neurodevelopmental disorders are a diverse group of behaviourally-relevant multifactorial disorders related to an impairment of growth, maturation, or development of the central nervous system. The ... More


Temporal Lobe Epilepsy and the Hippocampus

Radwa A.B. Badawy and Graeme D. Jackson

in The Clinical Neurobiology of the Hippocampus: An integrative view

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199592388
eISBN:
9780199949922
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199592388.003.0013
Subject:
Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience

Hippocampal sclerosis (HS) is the commonest cause of temporal lobe epilepsy which accounts for 3–50% of all epilepsy syndromes. This chapter reviews the pathological substrate of HS and mesial ... More


[11C]Flumazenil Positron Emission Tomography

Matthias J. Koepp

in Neuroimaging in Epilepsy

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195342765
eISBN:
9780199863617
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195342765.003.0011
Subject:
Neuroscience, Disorders of the Nervous System

This chapter examines the role of Flumazenil (PET) PET in research and clinical practice. FMZ is a good marker for the integrity of GABA-ergic neurotransmission in epilepsy and other diseases. First, ... More


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