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Extreme diversity in the major histocompatibility complex

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0012
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

The Major Histocompatibility Complex on chromosome 6 encodes a diverse array of genes involved in the immune and inflammatory response. The region is remarkably polymorphic and has been associated ... More


Genotypic Specificity of Grass-Endophyte Interactions

Gregory P. Cheplick and Stanley H. Faeth

in Ecology and Evolution of the Grass-Endophyte Symbiosis

Published in print:
2009
Published Online:
January 2009
ISBN:
9780195308082
eISBN:
9780199867462
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195308082.003.0004
Subject:
Biology, Ecology

For ongoing coevolution of the grass-endophyte symbiosis through the agents of natural selection, there must be genetic variation within populations for both host and endophyte. The breeding systems ... More


SNPs, HapMap, and common disease

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0009
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

The extent of single nucleotide polymorphism is reviewed, together with insights gained into the nature of allelic architecture in terms of haplotypes, linkage disequilibrium and recombination. The ... More


Fine scale sequence diversity and signatures of selection

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0010
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

Genetic diversity observed in human populations provides unique insights into the selective pressures which have shaped our recent evolutionary past. Evidence to support this view is described in ... More


How to measure genetic variation

Jacob Höglund

in Evolutionary Conservation Genetics

Published in print:
2009
Published Online:
May 2009
ISBN:
9780199214211
eISBN:
9780191706660
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199214211.003.0002
Subject:
Biology, Biodiversity / Conservation Biology, Evolutionary Biology / Genetics

This chapter reviews the most common measures of genetic variation used in conservation genetic studies. These include percentage of polymorphic loci, alleles per locus/allelic richness, expected ... More


Purity and Danger: When One Stands for Many

Michael J. Montoya

in Making the Mexican Diabetic: Race, Science, and the Genetics of Inequality

Published in print:
2011
Published Online:
May 2012
ISBN:
9780520267305
eISBN:
9780520949003
Item type:
chapter
Publisher:
University of California Press
DOI:
10.1525/california/9780520267305.003.0004
Subject:
Anthropology, American and Canadian Cultural Anthropology

This chapter presents the representations of diabetes as a racialized disease with the ideologies of research participation and humanitarian service found within the sampling apparatuses along the ... More


Human Population Genomics and the Dilemma of Difference

Jenny Reardon

in Reframing Rights: Bioconstitutionalism in the Genetic Age

Published in print:
2011
Published Online:
August 2013
ISBN:
9780262015950
eISBN:
9780262298667
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262015950.003.0114
Subject:
Biology, Bioethics

This chapter introduces the theme of bottom-up agency with an account of struggles for authority between socially and scientifically constituted groups of genetic research subjects. It addresses how ... More


Who Represents the Human Genome? What Is the Human Genome?

Jenny Reardon

in The Postgenomic Condition: Ethics, Justice, and Knowledge after the Genome

Published in print:
2017
Published Online:
September 2018
ISBN:
9780226344553
eISBN:
9780226345192
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226345192.003.0004
Subject:
Sociology, Health, Illness, and Medicine

Who in the world could and should properly represent variation in the human genome? American genome scientists and policy makers argued that previous global efforts to represent the variability of ... More


Inferring evolutionary processes from DNA sequence data

Glenn-Peter Sætre and Mark Ravinet

in Evolutionary Genetics: Concepts, Analysis, and Practice

Published in print:
2019
Published Online:
July 2019
ISBN:
9780198830917
eISBN:
9780191868993
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198830917.003.0007
Subject:
Biology, Evolutionary Biology / Genetics, Biomathematics / Statistics and Data Analysis / Complexity Studies

The allelic evolutionary genetic models explored so far are applicable to genetic markers. However, DNA sequences harbor a lot of information about the evolutionary past that would be missed if ... More


Using Molecular Data to Detect Selection: Signatures from Recent Single Events

Bruce Walsh and Michael Lynch

in Evolution and Selection of Quantitative Traits

Published in print:
2018
Published Online:
September 2018
ISBN:
9780198830870
eISBN:
9780191868986
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198830870.003.0009
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

Different types and phases of a selective sweep (hard, soft, partial, polygenic) generate different patterns of departures from neutrality, and hence require different tests. It is thus not ... More


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