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Lessons from haemoglobin

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0001
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

Study of genetic variation at the globin genes has provided a series of fundamental insights the nature and extent of genetic diversity and its functional consequences. This chapter provides a primer ... More


Respiratory systems

A. Schmidt-Rhaesa

in The Evolution of Organ Systems

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198566687
eISBN:
9780191718007
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566687.003.0011
Subject:
Biology, Evolutionary Biology / Genetics

Oxygen uptake is essential for animals, and many animals take up oxygen through their external surface. In these cases particular respiratory structures are not formed; in water these are generally ... More


Balancing Selection and Disease

Norman A. Johnson

in Darwinian Detectives: Revealing the Natural History of Genes and Genomes

Published in print:
2007
Published Online:
September 2007
ISBN:
9780195306750
eISBN:
9780199790203
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195306750.003.0005
Subject:
Biology, Evolutionary Biology / Genetics

Some forms of selection, called “balancing selection” can maintain variation. Human beta-hemoglobin is an example of a gene under balancing selection. Individuals having two copies of the sickle ... More


Respiratory Biology of Animals: evolutionary and functional morphology

Steven F. Perry, Markus Lambertz, and Anke Schmitz

Published in print:
2019
Published Online:
November 2019
ISBN:
9780199238460
eISBN:
9780191864056
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199238460.001.0001
Subject:
Biology, Animal Biology, Developmental Biology

The aim of this book is to shed light on one of the most fundamental processes of life in the various lineages of animals: respiration. It provides a certain background on the physiological side of ... More


Pharmacology

B S K Kamath and Sarah Turle

in MCQs for the Primary FRCA

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199575770
eISBN:
9780191917899
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199575770.003.0007
Subject:
Clinical Medicine and Allied Health, Professional Development in Medicine


Pharmacology

B S K Kamath and Sarah Turle

in MCQs for the Primary FRCA

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199575770
eISBN:
9780191917899
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199575770.003.0009
Subject:
Clinical Medicine and Allied Health, Professional Development in Medicine


Architects of Structural Biology: Bragg, Perutz, Kendrew, Hodgkin

John Meurig Thomas

Published in print:
2020
Published Online:
March 2020
ISBN:
9780198854500
eISBN:
9780191888793
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198854500.001.0001
Subject:
Physics, Crystallography: Physics, Soft Matter / Biological Physics

Designed for the non-specialist, the explanations and illustrations used here describe the work, personalities, collaborations, and idiosyncrasies of four of the most distinguished Nobel Laureates of ... More


Genetic haematological disorders

Sir David Weatherall and Elizabeth A. Letsky

in Antenatal and Neonatal Screening

Published in print:
2000
Published Online:
September 2009
ISBN:
9780192628268
eISBN:
9780191723605
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192628268.003.0011
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This main focus of this chapter is on genetic disorders of the structure or synthesis of haemoglobin — especially sickle cell disease and the thalassaemias, which are common enough in many ... More


Malaria

Robert L. Perlman

in Evolution and Medicine

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199661718
eISBN:
9780191774720
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199661718.003.0009
Subject:
Biology, Evolutionary Biology / Genetics

Despite recent progress in reducing the prevalence of malaria, it remains a major cause of morbidity and mortality, especially in infants and young children. Malaria is the infectious disease that ... More


Hemoglobin: Insights into protein structure, function, and evolution

Jay F. Storz

Published in print:
2018
Published Online:
December 2018
ISBN:
9780198810681
eISBN:
9780191847929
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198810681.001.0001
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

The aims of this book are to provide a synthesis of our current understanding of hemoglobin structure, function, and evolution, and to illustrate how research on this paradigmatic protein has ... More


Decoupling Transfusion and Genetics: Blood in the New Human Biology

Jenny Bangham

in Blood Relations: Transfusion and the Making of Human Genetics

Published in print:
2020
Published Online:
May 2021
ISBN:
9780226739977
eISBN:
9780226740171
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226740171.003.0011
Subject:
History, History of Science, Technology, and Medicine

By the 1950s, blood groups were no longer the only blood-based human genetic traits. Human blood was yielding new heritable polymorphisms, such as variable hemoglobin, white-cell antigens, and enzyme ... More


Green Chemistry: Photosynthesis

Peter Atkins

in Reactions: The private life of atoms

Published in print:
2011
Published Online:
November 2020
ISBN:
9780199695126
eISBN:
9780191918445
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199695126.003.0032
Subject:
Chemistry, Physical Chemistry

Each square metre of the Earth receives up to 1 kW of solar radiation, with the exact intensity depending on latitude, season, time of day, and weather. A significant amount of this energy is ... More


Gene duplication and hemoglobin isoform differentiation

Jay F. Storz

in Hemoglobin: Insights into protein structure, function, and evolution

Published in print:
2018
Published Online:
December 2018
ISBN:
9780198810681
eISBN:
9780191847929
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198810681.003.0006
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

Chapter 6 explores the physiological significance of gene duplication and hemoglobin isoform differentiation. Repeated rounds of gene duplication and divergence during the evolution of jawed ... More


The Modern Synthesis: Discussion

Eva Jablonka

in Transformations of Lamarckism: From Subtle Fluids to Molecular Biology

Published in print:
2011
Published Online:
August 2013
ISBN:
9780262015141
eISBN:
9780262295642
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262015141.003.0014
Subject:
Biology, Evolutionary Biology / Genetics

This chapter discusses important issues concerning the Modern Synthesis. First, it describes the neglected ideas and overlooked theories of Cyril Darlington. It then discusses the decline of the ... More


Perutz and Kendrew: The Heroic Era of Structural Molecular Biology

John Meurig Thomas

in Architects of Structural Biology: Bragg, Perutz, Kendrew, Hodgkin

Published in print:
2020
Published Online:
March 2020
ISBN:
9780198854500
eISBN:
9780191888793
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198854500.003.0005
Subject:
Physics, Crystallography: Physics, Soft Matter / Biological Physics

When Perutz and Kendrew embarked on their determination of the structures of haemoglobin and myoglobin, most scientists felt that they would never succeed. These molecules contain approximately ... More


Home, sweet home: An exhibition of detergents, dangers, delights and delusions

John Emsley

in Molecules at an Exhibition: Portraits of Intriguing Materials in Everyday Life

Published in print:
1998
Published Online:
November 2020
ISBN:
9780198502661
eISBN:
9780191916458
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198502661.003.0008
Subject:
Chemistry, Physical Chemistry

Few people today lead home-centred lives, and perhaps that’s how it should be. For earlier generations the home was all important: it was a place of comfort after a hard day’s work, a place to be ... More


Landscape room: environmental cons, concerns and comments: An exhibition of molecules that stalk the world

John Emsley

in Molecules at an Exhibition: Portraits of Intriguing Materials in Everyday Life

Published in print:
1998
Published Online:
November 2020
ISBN:
9780198502661
eISBN:
9780191916458
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198502661.003.0010
Subject:
Chemistry, Physical Chemistry

A hundred years ago, if you talked about protecting the environment you meant preventing floods or forest fires. Homes and farms could be ruined and families wiped out by a flash flood, a surge ... More


Elements from Hell: An exhibition of molecules that are mainly malevolent

John Emsley

in Molecules at an Exhibition: Portraits of Intriguing Materials in Everyday Life

Published in print:
1998
Published Online:
November 2020
ISBN:
9780198502661
eISBN:
9780191916458
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198502661.003.0012
Subject:
Chemistry, Physical Chemistry

The road to hell is paved with good intentions … so the old saying goes. In this Gallery I want to show you that this can be indeed true, but it is also true that the road to hell can be paved with ... More


A study in scarlet: The role of hemoglobin in blood gas transport

Jay F. Storz

in Hemoglobin: Insights into protein structure, function, and evolution

Published in print:
2018
Published Online:
December 2018
ISBN:
9780198810681
eISBN:
9780191847929
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198810681.003.0002
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

Chapter 2 provides an overview of hemoglobin function and its physiological role in respiratory gas transport. Much of the chapter is devoted to explaining the physiological significance of ... More


Allosteric theory

Jay F. Storz

in Hemoglobin: Insights into protein structure, function, and evolution

Published in print:
2018
Published Online:
December 2018
ISBN:
9780198810681
eISBN:
9780191847929
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198810681.003.0003
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

Chapter 3 provides a brief overview of allostery, the modulation of protein activity that is caused by an indirect interaction between structurally remote binding sites. In this mode of ... More


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