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Lessons from haemoglobin

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0001
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

Study of genetic variation at the globin genes has provided a series of fundamental insights the nature and extent of genetic diversity and its functional consequences. This chapter provides a primer ... More


Respiratory systems

A. Schmidt-Rhaesa

in The Evolution of Organ Systems

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198566687
eISBN:
9780191718007
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566687.003.0011
Subject:
Biology, Evolutionary Biology / Genetics

Oxygen uptake is essential for animals, and many animals take up oxygen through their external surface. In these cases particular respiratory structures are not formed; in water these are generally ... More


Balancing Selection and Disease

Norman A. Johnson

in Darwinian Detectives: Revealing the Natural History of Genes and Genomes

Published in print:
2007
Published Online:
September 2007
ISBN:
9780195306750
eISBN:
9780199790203
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195306750.003.0005
Subject:
Biology, Evolutionary Biology / Genetics

Some forms of selection, called “balancing selection” can maintain variation. Human beta-hemoglobin is an example of a gene under balancing selection. Individuals having two copies of the sickle ... More


Respiratory Biology of Animals: evolutionary and functional morphology

Steven F. Perry, Markus Lambertz, and Anke Schmitz

Published in print:
2019
Published Online:
November 2019
ISBN:
9780199238460
eISBN:
9780191864056
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199238460.001.0001
Subject:
Biology, Animal Biology, Developmental Biology

The aim of this book is to shed light on one of the most fundamental processes of life in the various lineages of animals: respiration. It provides a certain background on the physiological side of ... More


Chapter 14

Rakesh Tandon (ed.)

in Structured Oral Examination Practice for the Final FRCA

Published in print:
2011
Published Online:
November 2020
ISBN:
9780199584017
eISBN:
9780191917950
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199584017.003.0020
Subject:
Clinical Medicine and Allied Health, Professional Development in Medicine


Pharmacology

B S K Kamath and Sarah Turle

in MCQs for the Primary FRCA

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199575770
eISBN:
9780191917899
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199575770.003.0007
Subject:
Clinical Medicine and Allied Health, Professional Development in Medicine


Pharmacology

B S K Kamath and Sarah Turle

in MCQs for the Primary FRCA

Published in print:
2010
Published Online:
November 2020
ISBN:
9780199575770
eISBN:
9780191917899
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199575770.003.0009
Subject:
Clinical Medicine and Allied Health, Professional Development in Medicine


Perioperative Medicine

Caroline Whymark, Ross Junkin, and Judith Ramsey

in SBAs for the Final FRCA

Published in print:
2019
Published Online:
November 2020
ISBN:
9780198803294
eISBN:
9780191917172
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198803294.003.0005
Subject:
Clinical Medicine and Allied Health, Professional Development in Medicine


Architects of Structural Biology: Bragg, Perutz, Kendrew, Hodgkin

John Meurig Thomas

Published in print:
2020
Published Online:
March 2020
ISBN:
9780198854500
eISBN:
9780191888793
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198854500.001.0001
Subject:
Physics, Crystallography: Physics, Soft Matter / Biological Physics

Designed for the non-specialist, the explanations and illustrations used here describe the work, personalities, collaborations, and idiosyncrasies of four of the most distinguished Nobel Laureates of ... More


Genetic haematological disorders

Sir David Weatherall and Elizabeth A. Letsky

in Antenatal and Neonatal Screening

Published in print:
2000
Published Online:
September 2009
ISBN:
9780192628268
eISBN:
9780191723605
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192628268.003.0011
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This main focus of this chapter is on genetic disorders of the structure or synthesis of haemoglobin — especially sickle cell disease and the thalassaemias, which are common enough in many ... More


Hemoglobin: Insights into protein structure, function, and evolution

Jay F. Storz

Published in print:
2018
Published Online:
December 2018
ISBN:
9780198810681
eISBN:
9780191847929
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198810681.001.0001
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

The aims of this book are to provide a synthesis of our current understanding of hemoglobin structure, function, and evolution, and to illustrate how research on this paradigmatic protein has ... More


Malaria

Robert L. Perlman

in Evolution and Medicine

Published in print:
2013
Published Online:
December 2013
ISBN:
9780199661718
eISBN:
9780191774720
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199661718.003.0009
Subject:
Biology, Evolutionary Biology / Genetics

Despite recent progress in reducing the prevalence of malaria, it remains a major cause of morbidity and mortality, especially in infants and young children. Malaria is the infectious disease that ... More


Seven Chemical Clues to First Life

Ben McFarland

in A World From Dust: How the Periodic Table Shaped Life

Published in print:
2016
Published Online:
November 2020
ISBN:
9780190275013
eISBN:
9780197559604
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190275013.003.0009
Subject:
Chemistry, Physical Chemistry

I was struck by two colorful examples of the hidden chemical structure of the world while I was supposed to be on vacation on Whidbey Island in Washington State, at a ... More


Green Chemistry: Photosynthesis

Peter Atkins

in Reactions: The private life of atoms

Published in print:
2011
Published Online:
November 2020
ISBN:
9780199695126
eISBN:
9780191918445
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199695126.003.0032
Subject:
Chemistry, Physical Chemistry

Each square metre of the Earth receives up to 1 kW of solar radiation, with the exact intensity depending on latitude, season, time of day, and weather. A significant amount of this energy is ... More


Gene duplication and hemoglobin isoform differentiation

Jay F. Storz

in Hemoglobin: Insights into protein structure, function, and evolution

Published in print:
2018
Published Online:
December 2018
ISBN:
9780198810681
eISBN:
9780191847929
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198810681.003.0006
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

Chapter 6 explores the physiological significance of gene duplication and hemoglobin isoform differentiation. Repeated rounds of gene duplication and divergence during the evolution of jawed ... More


Wheels within Wheels

Ben McFarland

in A World From Dust: How the Periodic Table Shaped Life

Published in print:
2016
Published Online:
November 2020
ISBN:
9780190275013
eISBN:
9780197559604
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190275013.003.0010
Subject:
Chemistry, Physical Chemistry

Something strange and old lurks under the ice in Antarctica, at a place called Blood Falls. It is an echo of the early Earth. Blood Falls is hard to reach and easy to ... More


The Small Molecules of Life

Eugene H. Cordes

in Title Pages

Published in print:
2014
Published Online:
November 2020
ISBN:
9780199337149
eISBN:
9780197562864
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199337149.003.0006
Subject:
Chemistry, Medicinal Chemistry

All life on Earth is unified. Life may have flickered into being, only to be subsequently extinguished, many times during the early days of our planet’s evolution. But ... More


Proteins: Molecular Wonders in Three Dimensions

Eugene H. Cordes

in Title Pages

Published in print:
2014
Published Online:
November 2020
ISBN:
9780199337149
eISBN:
9780197562864
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780199337149.003.0007
Subject:
Chemistry, Medicinal Chemistry

I grew up in a solid middle-class family, largely of German descent, in a city of modest size in central Nebraska. Like a lot of such families, our diet was based on ... More


Duplication

Mary Jane West-Eberhard

in Developmental Plasticity and Evolution

Published in print:
2003
Published Online:
November 2020
ISBN:
9780195122343
eISBN:
9780197561300
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195122343.003.0016
Subject:
Earth Sciences and Geography, Palaeontology: Earth Sciences

Duplication occurs at all levels of phenotypic organization. It was among the first developmental phenomena to attract the attention of biologists ... More


Modularity

Mary Jane West-Eberhard

in Developmental Plasticity and Evolution

Published in print:
2003
Published Online:
November 2020
ISBN:
9780195122343
eISBN:
9780197561300
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195122343.003.0009
Subject:
Earth Sciences and Geography, Palaeontology: Earth Sciences

Modularity, like the responsiveness that gives rise to it during development and evolution, is a universal property of living things and a fundamental ... More


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