Willi Roman and Schwab Martin E.
- Published in print:
- 2011
- Published Online:
- August 2013
- ISBN:
- 9780262015233
- eISBN:
- 9780262295444
- Item type:
- chapter
- Publisher:
- The MIT Press
- DOI:
- 10.7551/mitpress/9780262015233.003.0029
- Subject:
- Neuroscience, Research and Theory
This chapter concentrates on the characteristics of Nogo-A and its signaling pathway components in neurite growth inhibition and describes mechanisms of central nervous system (CNS) repair after ...
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This chapter concentrates on the characteristics of Nogo-A and its signaling pathway components in neurite growth inhibition and describes mechanisms of central nervous system (CNS) repair after Nogo-A blockade and its implications for clinical application. This chapter shows that targeting the signaling components by appropriate blockers can prevent growth cone collapse and growth inhibition induced by Nogo-A and several other inhibitors. It also suggests that neutralization of the most potent of inhibitory molecules, Nogo-A, in animal models of spinal cord injury (SCI) and stroke has been shown to be effective in triggering axonal repair mechanisms and behavioral improvements.Less
This chapter concentrates on the characteristics of Nogo-A and its signaling pathway components in neurite growth inhibition and describes mechanisms of central nervous system (CNS) repair after Nogo-A blockade and its implications for clinical application. This chapter shows that targeting the signaling components by appropriate blockers can prevent growth cone collapse and growth inhibition induced by Nogo-A and several other inhibitors. It also suggests that neutralization of the most potent of inhibitory molecules, Nogo-A, in animal models of spinal cord injury (SCI) and stroke has been shown to be effective in triggering axonal repair mechanisms and behavioral improvements.
