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Macromolecular Crystallization and Crystal Perfection

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199213252
eISBN:
9780191707575
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213252.001.0001
Subject:
Physics, Crystallography

Structural crystallography provides key information to understand the mechanism involved for biological processes. The technique requires high‐quality crystals. The book Macromolecular ... More


The Antisocial Brain

Nikolas Rose and Joelle M. Abi-Rached

in Neuro: The New Brain Sciences and the Management of the Mind

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691149608
eISBN:
9781400846337
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691149608.003.0007
Subject:
Neuroscience, Development

This chapter examines the arguments that claim that human antisocial behavior—notably impulsivity, aggression, and related forms of criminal conduct—have neurobiological roots. While neurobiological ... More


Perspectives

ZIHENG YANG

in Computational Molecular Evolution

Published in print:
2006
Published Online:
April 2010
ISBN:
9780198567028
eISBN:
9780191728280
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198567028.003.0010
Subject:
Biology, Evolutionary Biology / Genetics

This chapter discusses current challenges and future perspectives of the field. Topics covered include theoretical issues in phylogeny reconstruction, computational issues in analysis of large and ... More


Hidden Markov Processes: Theory and Applications to Biology

M. Vidyasagar

Published in print:
2014
Published Online:
October 2017
ISBN:
9780691133157
eISBN:
9781400850518
Item type:
book
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691133157.001.0001
Subject:
Mathematics, Probability / Statistics

This book explores important aspects of Markov and hidden Markov processes and the applications of these ideas to various problems in computational biology. It starts from first principles, so that ... More


Statistical Theory and Methods for Evolutionary Genomics

Xun Gu

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199213269
eISBN:
9780191594762
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213269.001.0001
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

Evolutionary genomics is a relatively new research field with the ultimate goal of understanding the underlying evolutionary and genetic mechanisms for the emergence of genome complexity under ... More


The animal in the genome: comparative genomics and evolution

Richard R. Copley

in Animal Evolution: Genomes, Fossils, and Trees

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199549429
eISBN:
9780191721601
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199549429.003.0014
Subject:
Biology, Evolutionary Biology / Genetics, Developmental Biology

Comparisons between completely sequenced metazoan genomes have generally emphasized how similar their encoded protein content is, even when the comparison is between phyla. Given the manifest ... More


Future directions in polar limnology

Johanna Laybourn-Parry and Warwick F. Vincent

in Polar Lakes and Rivers: Limnology of Arctic and Antarctic Aquatic Ecosystems

Published in print:
2008
Published Online:
January 2009
ISBN:
9780199213887
eISBN:
9780191707506
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199213887.003.0017
Subject:
Biology, Ecology, Aquatic Biology

This concluding chapter identifies some of the emerging concepts and technologies that will drive future advances in polar limnology. These include the increased awareness of climate and related ... More


Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis, and Julian Little (eds)

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.001.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery ... More


Human genome epidemiology: the road map revisited

Muin J. Khoury, Sara R. Bedrosian, Marta Gwinn, Julian Little, Julian P. T. Higgins, and John P. A. Ioannidis

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter begins with a discussion of the Rationale for a Second Edition of Human Genome Epidemiology. It then discusses public health applications of genome-wide association studies, the ... More


The public health genomics enterprise

Philippa Brice and Ron Zimmern

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0003
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter considers the origins and emergence of public health genomics as a subdiscipline of public health, moving on to a consideration of current practice with some specific examples. It then ... More


Chance Untamed and the Return of Fate

Margaret Lock

in The Alzheimer Conundrum: Entanglements of Dementia and Aging

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691149783
eISBN:
9781400848461
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691149783.003.0009
Subject:
Anthropology, Social and Cultural Anthropology

This chapter demonstrates a reader-friendly discussion about the shift in orientation by molecular biologists away from genes per se, into the wider fields of genomics and epigenetics—that is, to the ... More


The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: methods of the EGAPP Working Group

Steven M. Teutsch, Linda A. Bradley, Glenn E. Palomaki, James E. Haddow, Margaret Piper, Ned Calonge, W. David Dotson, Michael P. Douglas, and Alfred O. Berg

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0023
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative, established by the Office of Public Health Genomics at the Centers for Disease Control and Prevention, supports ... More


The use of family history in public health practice: the epidemiologic view

Rodolfo Valdez, Muin J. Khoury, and Paula W. Yoon

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0029
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

With the advent of molecular genetics, the accelerated mapping of human genes to specific chromosome locations was made possible without the use of detailed pedigrees. Moreover, following the ... More


Integrative Neuroscience and Personalized Medicine

Evian Gordon, MD, PhD and Stephen Koslow, PhD (eds)

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.001.0001
Subject:
Neuroscience, Disorders of the Nervous System

Key thoughts leaders and practitioners in personalized medicine distil its current status, future directions, and recommendation for successful implementation of for brain disorders. This text is a ... More


Creative and Predatory Technology

Geoff Mulgan

in The Locust and the Bee: Predators and Creators in Capitalism's Future

Published in print:
2015
Published Online:
October 2017
ISBN:
9780691165745
eISBN:
9781400866199
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691165745.003.0008
Subject:
Economics and Finance, Financial Economics

This chapter addresses the widespread assumption that capitalism's future can best be understood as made up of more, and better, technology. The scale of scientific and technological activity today ... More


Molecular replacement techniques for high-throughput structure determination

Marc Delarue

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0007
Subject:
Biology, Biochemistry / Molecular Biology

In the context of structural genomics projects, there are two main routes to consider for solving efficiently and rapidly the three-dimensional (3D) structure of the target gene products by ... More


MAD phasing

H. M. Krishna Murthy

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0008
Subject:
Biology, Biochemistry / Molecular Biology

From a relatively small beginning, nearly two decades ago, phase calculation using multiple-wavelength anomalous diffraction (MAD) data has become more widespread and generally used. This chapter ... More


Getting a macromolecular model: model building, refinement, and validation

R. J. Morris, A. Perrakis, and V. S. Lamzin

in Macromolecular Crystallography: conventional and high-throughput methods

Published in print:
2007
Published Online:
September 2007
ISBN:
9780198520979
eISBN:
9780191706295
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198520979.003.0011
Subject:
Biology, Biochemistry / Molecular Biology

This chapter casts the high-throughput automation efforts being developed to meet the needs of Structural Genomics initiatives in the framework of an optimization problem. It gives a general overview ... More


Personalized Medicine and Integrative Neuroscience: Toward Consensus Markers for Disorders of Brain Health

Leanne M. Williams and Evian Gordon

in Integrative Neuroscience and Personalized Medicine

Published in print:
2010
Published Online:
January 2011
ISBN:
9780195393804
eISBN:
9780199863495
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393804.003.0003
Subject:
Neuroscience, Disorders of the Nervous System

In the emerging new paradigm of “Personalized Medicine,” the goal is to shift the treatment for brain-related illness from trial and error into a bull’s-eye. To date, much of the research in ... More


Postscript and prospects

Anne E. Magurran

in Evolutionary Ecology: The Trinidadian Guppy

Published in print:
2005
Published Online:
September 2007
ISBN:
9780198527855
eISBN:
9780191713576
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198527855.003.0008
Subject:
Biology, Evolutionary Biology / Genetics

This concluding chapter draws together the main themes of the book before summarizing the legacy of the pioneer guppy researchers. It identifies some areas where research is likely to be directed in ... More


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