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Design and analysis issues in genome-wide association studies

Duncan C. Thomas

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0008
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The recent availability of commercial high-density genotyping technologies, combined with the identification of subsets of single nucleotide polymorphisms (SNPs) that are capable of “tagging” most of ... More


Case-control and cohort studies in the age of genome-wide associations

Teri Manolio

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0006
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Environmental modifiers of the effects of genetic variants, or gene-environment interactions, have received increased attention in recent years due to the recognition that genetic variants alone are ... More


Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases

Muin J. Khoury, Lars Bertram, Paolo Boffetta, Adam S. Butterworth, Stephen J. Chanock, Siobhan M. Dolan, Isabel Fortier, Montserrat Garcia-Closas, Marta Gwinn, Julian P. T. Higgins, A. Cecile J. W. Janssens, James M. Ostell, Ryan P. Owen, Roberta A. Pagon, Timothy R. Rebbeck, Nathaniel Rothman, Jonine L. Bernstein, Paul R. Burton, Harry Campbell, Anand P. Chokkalingam, Helena Furberg, Julian Little, Thomas R. O’Brien, Daniela Seminara, Paolo Vineis, Deborah M. Winn, Wei Yu, and John P. A. Ioannidis

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0012
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter reports the findings and recommendations from a multidisciplinary workshop, including geneticists, epidemiologists, journal editors, and bioinformatics experts, that was sponsored by the ... More


Genome-Wide Association Studies: Back to the Future

Margaret Lock

in The Alzheimer Conundrum: Entanglements of Dementia and Aging

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691149783
eISBN:
9781400848461
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691149783.003.0007
Subject:
Anthropology, Social and Cultural Anthropology

This chapter examines findings from the newly developed technology of genome-wide association studies (GWAS) being applied to the investigation of Alzheimer disease (AD), primarily in the United ... More


Principles of analysis of germline genetics

Jesus Gonzalez-Bosquet and Stephen J. Chanock

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0002
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter presents an overview of the development and progress in applications of genomic technologies, with a focus on genomic sequence variation. Topics discussed include genetic variation, ... More


Integration of the evidence on gene–disease associations: methods of HuGE reviews

Julian P. T. Higgins and Julian Little

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0011
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Human Genome Epidemiology (HuGE) reviews have been a cornerstone of the efforts of the Human Genome Epidemiology Network (HuGENet) to develop an online resource to house the cumulative and changing ... More


Human genome epidemiology: the road map revisited

Muin J. Khoury, Sara R. Bedrosian, Marta Gwinn, Julian Little, Julian P. T. Higgins, and John P. A. Ioannidis

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter begins with a discussion of the Rationale for a Second Edition of Human Genome Epidemiology. It then discusses public health applications of genome-wide association studies, the ... More


Its Rise, Its Fall, Its Rise? Interaction in the Twenty-First Century

James Tabery

in Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture

Published in print:
2014
Published Online:
January 2015
ISBN:
9780262027373
eISBN:
9780262324144
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262027373.003.0004
Subject:
History, History of Science, Technology, and Medicine

In 2003, Terrie Moffitt and Avshalom Caspi published a groundbreaking study examining how the serotonin transporter gene and stressful life events interact to contribute to the risk of developing ... More


Prostate Cancer

Catherine M. Tangen, Marian L. Neuhouser, and Janet L. Stanford

in Cancer Epidemiology and Prevention

Published in print:
2017
Published Online:
December 2017
ISBN:
9780190238667
eISBN:
9780190238698
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190238667.003.0053
Subject:
Public Health and Epidemiology, Epidemiology, Public Health

Prostate cancer is the most common solid tumor and the second leading cause of cancer-related mortality in American men. Worldwide, prostate cancer ranks second and fifth as a cause of cancer and ... More


Where Do We Go from Here?

Michael Beenstock

in Heredity, Family, and Inequality: A Critique of Social Sciences

Published in print:
2012
Published Online:
August 2013
ISBN:
9780262016926
eISBN:
9780262301381
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262016926.003.0007
Subject:
Economics and Finance, Econometrics

This chapter explores the possible contribution of genome-wide association studies (GWAS) to social science. Medical scientists have been looking for the human genome for genes that account for ... More


Modeling Linkage Disequilibrium and Performing Association Studies through Probabilistic Graphical Models: a Visiting Tour of Recent Advances

Christine Sinoquet and Raphaël Mourad

in Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Published in print:
2014
Published Online:
December 2014
ISBN:
9780198709022
eISBN:
9780191779619
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198709022.003.0009
Subject:
Mathematics, Probability / Statistics, Biostatistics

This chapter offers an in-depth review of recent developments based on probabilistic graphical models (PGMs) and dedicated to two major concerns: the fundamental task of modeling dependences within ... More


Genetic Epidemiology of Cancer

Christopher Haiman and David J. Hunter

in Textbook of Cancer Epidemiology

Published in print:
2018
Published Online:
February 2018
ISBN:
9780190676827
eISBN:
9780190676858
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190676827.003.0004
Subject:
Public Health and Epidemiology, Epidemiology, Public Health

This chapter explores the genetic epidemiology of cancer: the identification and quantification of inherited genetic factors, and their potential interaction with the environment, in the etiology of ... More


Molecular quantitative genetics

Henrik Jensen, Marta Szulkin, and Jon Slate

in Quantitative Genetics in the Wild

Published in print:
2014
Published Online:
August 2014
ISBN:
9780199674237
eISBN:
9780191779275
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199674237.003.0013
Subject:
Biology, Evolutionary Biology / Genetics, Ecology

Recent development of high-throughput genomics tools has made it possible and affordable to examine the molecular basis of variation in quantitative traits in studies of non-model species in the ... More


Behaving: Its Nature and Nurture (Part 2)

Kenneth F. Schaffner

in Behaving: What's Genetic, What's Not, and Why Should We Care?

Published in print:
2016
Published Online:
May 2016
ISBN:
9780195171402
eISBN:
9780190464103
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195171402.003.0003
Subject:
Philosophy, Philosophy of Science, Moral Philosophy

This chapter focuses on recent molecular approaches to behavioral genetics including gene finding and molecular genetics. In the latter the investigators identify critical DNA variants and trace the ... More


Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Michael Pluess (ed.)

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.001.0001
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

The science of psychological well-being has gained a lot of interest in the last decade. While it has been shown that psychological well-being is partly heritable, research focused on the ... More


Graphical Modeling of Biological Pathways in Genome-wide Association Studies

Min Chen, Judy Cho, and Hongyu Zhao

in Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Published in print:
2014
Published Online:
December 2014
ISBN:
9780198709022
eISBN:
9780191779619
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198709022.003.0012
Subject:
Mathematics, Probability / Statistics, Biostatistics

Genome-wide association studies (GWASs) are widely used to identify good candidates of disease-associated genes that are of interest for further follow-up studies. However, knowledge of biological ... More


Complex Traits in Natural Populations

Daniel L. Hartl

in A Primer of Population Genetics and Genomics

Published in print:
2020
Published Online:
August 2020
ISBN:
9780198862291
eISBN:
9780191895074
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198862291.003.0009
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies, Evolutionary Biology / Genetics

This chapter could as well be titled “Population Genomics,” although many aspects of population genomics are integrated throughout the other chapters. It includes estimates of mutational variance and ... More


Scoring, Searching and Evaluating Bayesian Network Models of Gene-phenotype Association

Xia Jiang, Shyam Visweswaran, and Richard E. Neapolitan

in Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Published in print:
2014
Published Online:
December 2014
ISBN:
9780198709022
eISBN:
9780191779619
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198709022.003.0011
Subject:
Mathematics, Probability / Statistics, Biostatistics

The arrival of genome-wide association studies (GWASs) has opened the exciting possibility of identifying genetic variations (single nucleotide polymorphisms (SNPs)) that underlie common diseases. ... More


The Apple and the Tree: Galton Revisited

Michael Beenstock

in Heredity, Family, and Inequality: A Critique of Social Sciences

Published in print:
2012
Published Online:
August 2013
ISBN:
9780262016926
eISBN:
9780262301381
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262016926.003.0001
Subject:
Economics and Finance, Econometrics

This book examines the roles of heredity, family, and social environment in shaping outcomes among humans, including anthropometric, behavioral, psychological, and economic outcomes. Drawing on ... More


Methodology of quantitative behavior and molecular genetics

Susan C. South and Amber M. Jarnecke

in Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Published in print:
2015
Published Online:
August 2015
ISBN:
9780199686674
eISBN:
9780191766787
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199686674.003.0003
Subject:
Psychology, Cognitive Psychology, Evolutionary Psychology

Within the social and behavioral sciences, there is a long history of the study of genetic and environmental influences on individual differences between people. This chapter provides an overview of ... More


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