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Genetic epidemiology

Harry Campbell and Susan Service

in Teaching Epidemiology: A guide for teachers in epidemiology, public health and clinical medicine

Published in print:
2010
Published Online:
May 2010
ISBN:
9780199239481
eISBN:
9780191716973
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199239481.003.012
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

A major challenge for epidemiology in the future is understanding the role of genetic risk factors and how genetic factors interact with environmental factors in causing disease. There is a clear ... More


Mendelian randomization: the contribution of genetic epidemiology to elucidating environmentally modifiable causes of disease

George Davey Smith and Shah Ebrahim

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0021
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Conventional risk factor epidemiology — directly studying environmentally modifiable exposures that may influence disease risk — and genetic epidemiology have similarities and differences. The ... More


The emergence of networks in human genome epidemiology: challenges and opportunities

Daniela Seminara, Muin J. Khoury, Thomas R. O’Brien, Teri Manolio, Marta Gwinn, Julian Little, Julian P. T. Higgins, Jonine L. Bernstein, Paolo Boffetta, Melissa L. Bondy, Molly S. Bray, Paul E. Brenchley, Patricia A. Buffler, Juan Pablo Casas, Anand P. Chokkalingam, John Danesh, George Davey Smith, Siobhan M. Dolan, Ross Duncan, Nelleke A. Gruis, Mia Hashibe, David J. Hunter, Marjo-Riitta Jarvelin, Beatrice Malmer, Demetrius M. Maraganore, Julia A. Newton-Bishop, Elio Riboli, Georgia Salanti, Emanuela Taioli, Nic Timpson, André G. Uitterlinden, Paolo Vineis, Nick Wareham, Deborah M. Winn, Ron Zimmern, and John P. A. Ioannidis

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0007
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The Human Genome Epidemiology Network (HuGENet) recently launched a global network of consortia working on human genome epidemiology. This Network of Investigator Networks aims to create a resource ... More


The challenge of assessing complex gene– environment and gene–gene interactions

Peter Kraft and David J. Hunter

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0009
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses the study of gene-environment and gene-gene interactions in genetic epidemiology. It starts with a review of the definition of statistical gene-environment interaction, which ... More


Genetic Epidemiology for Case-Based Designs

M. Daniele Fallin and W.H. Linda Kao

in The Case-Control Method: Design and Applications

Published in print:
2009
Published Online:
September 2009
ISBN:
9780195187113
eISBN:
9780199864898
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195187113.003.0008
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Genetic epidemiology is one of the most rapidly growing fields of epidemiologic research. Almost every human disease has some genetic component. The main purpose of genetic epidemiology is to ... More


Genetic Epidemiology of Neurologic Disease

Lorene M. Nelson, Caroline M. Tanner, Stephen K. Van Den Eeden, and Valerie M. McGuire

in Neuroepidemiology: From principles to practice

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195133790
eISBN:
9780199863730
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195133790.003.04
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter begins with a discussion of Mendelian versus complex (non-Mendelian) neurological disorders, followed by an overview of the structure of DNA and the molecular basis of disease. It ... More


Theoretical underpinning for the use of sibling studies in life course epidemiology

Kate W Strully and Gita D Mishra

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0003
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Siblings can have a great deal in common (e.g., parents, genes, early life home env1ironments, etc.), but they are also distinct individuals with unique personalities and physical traits. This ... More


Theoretical underpinning for the use of intergenerational studies in life course epidemiology

Debbie A Lawlor, Sam Leary, and George Davey Smith

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0002
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Intergenerational studies have been widely used in life course epidemiology both to examine primary research hypotheses and to explore underlying mechanisms for established associations. This chapter ... More


Theoretical underpinning for the use of twin studies in life course epidemiology

Ruth J F Loos, Charlotte L Ridgway, and Ken K Ong

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0004
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

The classical twin design is used in genetic epidemiology to estimate the heritability of a trait or disease. Despite potential biases for certain traits at specific stages during the life course, ... More


Discussant chapter—summary of the theoretical approaches to family-based studies in life course epidemiology

Hazel M Inskip

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0005
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Chapters 2 to 4 describe three specific approaches to family studies, namely, intergenerational, sibling, and twin studies. All can be used to assist in distinguishing between genetic and ... More


The future of family-based studies in life course epidemiology: challenges and opportunities

Gita D Mishra and Debbie A Lawlor

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0017
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Family-based studies can provide a more comprehensive view of life course epidemiology than studies that do not engage with family effects. They can establish intergenerational associations, help to ... More


Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Deborah A. Lawlor and Gita D. Mishra (eds)

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.001.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Family based studies, including intergenerational, sibling and twin studies, are increasingly used to explore life course epidemiology. However, understanding the underlying assumptions of these ... More


Why family matters: an introduction

Debbie A Lawlor and Gita D Mishra

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0001
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Family characteristics and interactions can directly affect one's health and wellbeing across the life course. In addition to the importance of recruiting and collecting data on family members, ... More


Genetic epidemiology of migraine

Kathleen R. Merikangas

in Migraine: A Spectrum of Ideas

Published in print:
1990
Published Online:
March 2012
ISBN:
9780192618108
eISBN:
9780191724305
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192618108.003.0004
Subject:
Neuroscience, Disorders of the Nervous System

The hereditary nature of migraine has been reported consistently since it was first noted by S. A. Tissot in the 18th century. Indeed, the association between migraine and family history was believed ... More


Birth cohorts: a resource for life course studies

Anne-Marie Nybo Andersen, Mia Madsen, and Debbie A Lawlor

in Family matters: Designing, analysing and understanding family based studies in life course epidemiology

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199231034
eISBN:
9780191723841
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199231034.003.0006
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses issues concerned with the design and practicalities of setting up birth cohorts for life course epidemiology. The demand for a blueprint of the ideal birth cohort study is ... More


Genetic Epidemiology of Cancer

Christopher Haiman and David J. Hunter

in Textbook of Cancer Epidemiology

Published in print:
2018
Published Online:
February 2018
ISBN:
9780190676827
eISBN:
9780190676858
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190676827.003.0004
Subject:
Public Health and Epidemiology, Epidemiology, Public Health

This chapter explores the genetic epidemiology of cancer: the identification and quantification of inherited genetic factors, and their potential interaction with the environment, in the etiology of ... More


Implications of the genetics of alcoholism and addictions for public policy

David Goldman

in Alcohol: Science, Policy and Public Health

Published in print:
2013
Published Online:
May 2013
ISBN:
9780199655786
eISBN:
9780191757082
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199655786.003.0009
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter considers the implications of the genetics of alcoholism for public policy, drawing from reviews as well as original sources. The discussion covers the genetic epidemiology of alcoholism ... More


A Statistical Framework for Mediation in Environmental Epigenetics

Duncan C. Thomas

in Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262034685
eISBN:
9780262335522
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262034685.003.0011
Subject:
Biology, Biomathematics / Statistics and Data Analysis / Complexity Studies

The biological effects of genes depend upon how they are expressed in target tissues at various points in time, which is determined by their epigenetic state and in turn may be influenced by the ... More


Alcohol and carcinogenesis: mechanisms and biomarkers

C.J. Peter Eriksson

in Alcohol: Science, Policy and Public Health

Published in print:
2013
Published Online:
May 2013
ISBN:
9780199655786
eISBN:
9780191757082
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199655786.003.0024
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Alcohol consumption has been associated with cancers in various locations in the body including the upper aerodigestive tract, stomach, intestinal tract, liver, pancreas, bladder, lung, prostate, and ... More


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