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Genetics of gene expression

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0011
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

This chapter discusses the role of genetic variation in modulating gene expression and how this can help resolve functionally important regulatory variants. The successful application of genetic ... More


Gene expression: from precursor to mature neuron

Uwe Ernsberger

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0003
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter begins with a discussion of promoter analysis for the study of neuron-specific regulatory elements. It then discusses the regulation of neuronal gene expression by the neuron-restrictive ... More


Statistics and Informatics in Molecular Cancer Research

Carsten Wiuf and Claus L. Andersen (eds)

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199532872
eISBN:
9780191714467
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199532872.001.0001
Subject:
Mathematics, Probability / Statistics, Biostatistics

This book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters it discusses specific topics in cancer research, talks about how the topics give ... More


Bioinformatics of gene expression and copy number data integration

Outi Monni and Sampsa Hautaniemi

in Statistics and Informatics in Molecular Cancer Research

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199532872
eISBN:
9780191714467
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199532872.003.0004
Subject:
Mathematics, Probability / Statistics, Biostatistics

This chapter discusses methods to measure and integrate microarray-based copy number and gene expression data. It is well-known that gene copy number alterations are a key factor in cancer ... More


Molecular biology of myelination

EDWIN S. MONUKI and GREG LEMKE

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0007
Subject:
Neuroscience, Disorders of the Nervous System

This chapter considers illustrative examples of the structural and regulatory molecules involved in myelination. Topics discussed include the myelin sheath, the molecules of the myelin sheath, ... More


 Plasticity and Health: Social Influences on Gene Expression and Neural Development

Michael J. Meaney

in Interdisciplinary Research: Case Studies from Health and Social Science

Published in print:
2008
Published Online:
September 2008
ISBN:
9780195324273
eISBN:
9780199893966
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195324273.003.0011
Subject:
Psychology, Cognitive Neuroscience, Cognitive Psychology

This chapter presents an interdisciplinary study on the effect of parental care on the psychology and biology of offspring. The research program, conducted with rodents, provides a detailed model of ... More


Molecular Biology of Myelination

Anthony T. Campagnoni

in Neuroglia

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.003.0019
Subject:
Neuroscience, Development, Disorders of the Nervous System

This chapter presents a brief overview of the molecular biology of the myelin protein genes and their expression into mRNA and protein. Topics discussed include classic myelin basic proteins and ... More


Specific Neurodevelopmental Disorders and Attention

Kim Cornish and John Wilding

in Attention, Genes, and Developmental Disorders

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195179941
eISBN:
9780199864652
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195179941.003.009
Subject:
Neuroscience, Behavioral Neuroscience, Development

Chapter 9 addresses the complex issues that face research on neurodevelopmental disorders. These include the complexities of gene expression and taxonomies of cognitive processes, shared phenotypes, ... More


Genetic basis of human neuronal diseases

Mark E. S. Bailey

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems

This chapter summarizes what is known about the genes underlying a range of human diseases where the causative or associated gene is expressed in neurons and there is a clear primary effect on ... More


Synapse-to-nucleus calcium signalling

Giles E. Hardingham

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems

Many extracellular stimuli result in an elevation of intracellular calcium concentration. Calcium ions act as messengers, coupling many external events or stimuli to the cell's responses to those ... More


Ecological genomics

Jacob Höglund

in Evolutionary Conservation Genetics

Published in print:
2009
Published Online:
May 2009
ISBN:
9780199214211
eISBN:
9780191706660
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199214211.003.0007
Subject:
Biology, Biodiversity / Conservation Biology, Evolutionary Biology / Genetics

This chapter reviews advances in genomics and their applications to conservation genetics. Topics discussed include whole-genome sequencing (WGS), assembly and annotation of the massive amount of ... More


The Neuromolecular Brain

Nikolas Rose and Joelle M. Abi-Rached

in Neuro: The New Brain Sciences and the Management of the Mind

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691149608
eISBN:
9781400846337
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691149608.003.0002
Subject:
Neuroscience, Development

This chapter examines the neuromolecular and plastic brain. Ideas about plasticity and the openness of brains to environment influences, from initial evidence about nerve development, through the ... More


Sex differences: genetic, physiological, and ecological mechanisms

Turk Rhen

in Sex, Size and Gender Roles: Evolutionary Studies of Sexual Size Dimorphism

Published in print:
2007
Published Online:
September 2007
ISBN:
9780199208784
eISBN:
9780191709036
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199208784.003.0019
Subject:
Biology, Animal Biology

Females and males share the same genome, which places a significant constraint on the evolution of sex differences. This chapter begins with a review of current theory explaining the initial ... More


Transcriptional Regulation in Schizophrenia

Scott E. Hemby and Joann A. O’Connor

in Adolescent Psychopathology and the Developing Brain: Integrating Brain and Prevention Science

Published in print:
2007
Published Online:
May 2009
ISBN:
9780195306255
eISBN:
9780199863914
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195306255.003.0005
Subject:
Neuroscience, Development

Psychiatric diseases such as schizophrenia and autism spectrum disorders are generally considered to be neurodevelopmental in origin. Dysregulated gene and/or protein expression in the brain of adult ... More


Middle Wavelength Sensitive Photopigment Gene Expression is Absent in Deuteranomalous Colour Vision

Maureen Neitz, Kathryn Bollinger, and Jay Neitz

in Normal and Defective Colour Vision

Published in print:
2003
Published Online:
April 2010
ISBN:
9780198525301
eISBN:
9780191584947
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198525301.003.0033
Subject:
Psychology, Cognitive Neuroscience

The deutan-type colour vision deficiencies, deuteranopia, and deuteranomaly are the most common types of colour blindness. A known cause of deutan colour vision defects is the loss of genes encoding ... More


Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression

Michael J. Meaney

in Adolescent Psychopathology and the Developing Brain: Integrating Brain and Prevention Science

Published in print:
2007
Published Online:
May 2009
ISBN:
9780195306255
eISBN:
9780199863914
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195306255.003.0007
Subject:
Neuroscience, Development

This chapter provides an overview of the long-term effects of early stress on the subsequent development of both physical and mental disorder. It then discusses the role of maternal care during pre- ... More


Elementary, my dear Watson, the clue is in the genes…or is it?: SPECIAL LECTURE SPECIAL LECTURE to mark the centenary of the British Psychological Society

ANNETTE KARMILOFF-SMITH

in Proceedings of the British Academy, Volume 117: 2001 Lectures

Published in print:
2003
Published Online:
January 2013
ISBN:
9780197262795
eISBN:
9780191753954
Item type:
chapter
Publisher:
British Academy
DOI:
10.5871/bacad/9780197262795.003.0016
Subject:
History, Cultural History

This chapter argues that there is no one-to-one, direct mapping between specific sets of genes and cognitive-level outcomes. Rather, there are very indirect mappings, with the regulation of gene ... More


Neurodevelopmental Disorders Across the Lifespan: A neuroconstructivist approach

Emily K. Farran and Annette Karmiloff-Smith (eds)

Published in print:
2011
Published Online:
May 2012
ISBN:
9780199594818
eISBN:
9780191738166
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199594818.001.0001
Subject:
Psychology, Social Psychology, Developmental Psychology

Nowadays, it is widely accepted that there is no single influence (be it nature or nurture) on cognitive development. Cognitive abilities emerge as a result of interactions between gene expression, ... More


Gene Control of Cortical Excitability

Jeffrey L. Noebels

in The Cortical Neuron

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195083309
eISBN:
9780199847464
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195083309.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems

The genes that contribute to specific cortical excitability phenotypes are difficult to predict. But one group of genes expressed in central neurons can be operationally defined and constitute a ... More


Schizophrenia

Peter Falkai, Oliver Gruber, and Andrea Schmitt

in The Clinical Neurobiology of the Hippocampus: An integrative view

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199592388
eISBN:
9780199949922
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199592388.003.0016
Subject:
Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience

Schizophrenia is a chronic neurocognitive brain disorder with unknown pathophysiology. There is evidence for an interaction between risk genes and environmental factors playing a role during early as ... More


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