Zachary F. Mainen and Larry F. Abbott
- Published in print:
- 2007
- Published Online:
- March 2012
- ISBN:
- 9780198566564
- eISBN:
- 9780191724206
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198566564.003.0018
- Subject:
- Neuroscience, Molecular and Cellular Systems
Most synapses are made onto dendrites, and most excitatory connections are made onto dendritic spines. Synaptic plasticity is thus an intrinsically dendritic phenomenon, but the functional ...
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Most synapses are made onto dendrites, and most excitatory connections are made onto dendritic spines. Synaptic plasticity is thus an intrinsically dendritic phenomenon, but the functional significance of the structural, electrical, and molecular properties of dendrites for synaptic plasticity is still very poorly understood. Do dendrites have a computational or cell biological role in the modification of synaptic strength that is more than circumstantial? This chapter aims to summarize experimental data and theoretical considerations that may be relevant to the role of dendrites in synaptic plasticity. The focus is on associative Hebbian synaptic plasticity, including spike-timing-dependent forms, mediated by NMDA receptor activation.Less
Most synapses are made onto dendrites, and most excitatory connections are made onto dendritic spines. Synaptic plasticity is thus an intrinsically dendritic phenomenon, but the functional significance of the structural, electrical, and molecular properties of dendrites for synaptic plasticity is still very poorly understood. Do dendrites have a computational or cell biological role in the modification of synaptic strength that is more than circumstantial? This chapter aims to summarize experimental data and theoretical considerations that may be relevant to the role of dendrites in synaptic plasticity. The focus is on associative Hebbian synaptic plasticity, including spike-timing-dependent forms, mediated by NMDA receptor activation.
Joan Stiles, Judy S. Reilly, Susan C. Levine, Doris A. Trauner, and Ruth Nass
- Published in print:
- 2012
- Published Online:
- March 2015
- ISBN:
- 9780195389944
- eISBN:
- 9780190255718
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:osobl/9780195389944.003.0009
- Subject:
- Psychology, Cognitive Psychology
This chapter reviews research on the plasticity of intellectual functioning in children with perinatal lesions (PL). It addresses five questions: (1) Is the plasticity of the young brain sufficient ...
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This chapter reviews research on the plasticity of intellectual functioning in children with perinatal lesions (PL). It addresses five questions: (1) Is the plasticity of the young brain sufficient to support levels of IQ and school achievement in children with PL that are comparable to typically developing children? (2) Does the pattern of IQ scores exhibited by children with PL mirror the pattern seen in adults who have similar focal lesions? (3) Are the IQ scores of children with PL as stable over time as those of typically developing children? (4) What are the lesion characteristics that relate to IQ levels in children with PL? (5) Are the effects of input on IQ similar to those observed in typically developing children?Less
This chapter reviews research on the plasticity of intellectual functioning in children with perinatal lesions (PL). It addresses five questions: (1) Is the plasticity of the young brain sufficient to support levels of IQ and school achievement in children with PL that are comparable to typically developing children? (2) Does the pattern of IQ scores exhibited by children with PL mirror the pattern seen in adults who have similar focal lesions? (3) Are the IQ scores of children with PL as stable over time as those of typically developing children? (4) What are the lesion characteristics that relate to IQ levels in children with PL? (5) Are the effects of input on IQ similar to those observed in typically developing children?
