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Specific Neurodevelopmental Disorders and Attention

Kim Cornish and John Wilding

in Attention, Genes, and Developmental Disorders

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195179941
eISBN:
9780199864652
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195179941.003.009
Subject:
Neuroscience, Behavioral Neuroscience, Development

Chapter 9 addresses the complex issues that face research on neurodevelopmental disorders. These include the complexities of gene expression and taxonomies of cognitive processes, shared phenotypes, ... More


Genes and Atypical Attention

Kim Cornish and John Wilding

in Attention, Genes, and Developmental Disorders

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195179941
eISBN:
9780199864652
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195179941.003.0003
Subject:
Neuroscience, Behavioral Neuroscience, Development

Chapter 3 introduces the six core neurodevelopmental disorders and their genetic origins. The genetics of four disorders (Fragile X syndrome, Down syndrome, Williams syndrome and 22q11 deletion ... More


X-linked disorders

Sarah Bundey

in Antenatal and Neonatal Screening

Published in print:
2000
Published Online:
September 2009
ISBN:
9780192628268
eISBN:
9780191723605
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192628268.003.0005
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter describes the screening for three X-linked disorders: Duchenne muscular dystrophy, the Fragile X syndrome, and X-linked retinitis pigmentosa. The primary screening test for these ... More


Remaking the Normal versus the Pathological in Genetic Medicine

Daniel Navon

in Mobilizing Mutations: Human Genetics in the Age of Patient Advocacy

Published in print:
2019
Published Online:
May 2020
ISBN:
9780226638096
eISBN:
9780226638126
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226638126.003.0008
Subject:
History, History of Science, Technology, and Medicine

Genetic mutations often affect people in ways that are too complex or subtle to be captured by existing categories from fields like medicine and psychiatry. This chapter therefore explores the way ... More


Leveraging Mutations: Going from the Rare to the Common in Human Genetics

Daniel Navon

in Mobilizing Mutations: Human Genetics in the Age of Patient Advocacy

Published in print:
2019
Published Online:
May 2020
ISBN:
9780226638096
eISBN:
9780226638126
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226638126.003.0004
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the practice of “leveraging” genetic mutations. When a rare mutation is strongly associated with a common trait or medical condition, biomedical researchers often use the ... More


The Loops That Tie: Mutations in the Trading Zone of Autism Genetics

Daniel Navon

in Mobilizing Mutations: Human Genetics in the Age of Patient Advocacy

Published in print:
2019
Published Online:
May 2020
ISBN:
9780226638096
eISBN:
9780226638126
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226638126.003.0005
Subject:
History, History of Science, Technology, and Medicine

The intertwined histories of autism and genomic designation show how genetics and classification can shape one another in unexpectedly dynamic ways. This chapter recounts the decades-long looping ... More


Neurodevelopmental Disorders

Alexander Prehn-Kristensen, Richard Cooke, Lioba Baving, and Cynthia Schumann

in The Clinical Neurobiology of the Hippocampus: An integrative view

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199592388
eISBN:
9780199949922
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199592388.003.0010
Subject:
Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience

Neurodevelopmental disorders are a diverse group of behaviourally-relevant multifactorial disorders related to an impairment of growth, maturation, or development of the central nervous system. The ... More


Integrating domain-general and domain-specific developmental processes: Cross-syndrome, cross-domain dynamics

Ann Steele, Janice Brown, and Gaia Scerif

in Neurodevelopmental Disorders Across the Lifespan: A neuroconstructivist approach

Published in print:
2011
Published Online:
May 2012
ISBN:
9780199594818
eISBN:
9780191738166
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199594818.003.0079
Subject:
Psychology, Social Psychology, Developmental Psychology

This chapter asks novel questions of old and new data, aiming to elucidate the relationships between attention, language, and number early in the development of people with Williams syndrome (WS). In ... More


Assembling a New Kind of Person

Daniel Navon

in Mobilizing Mutations: Human Genetics in the Age of Patient Advocacy

Published in print:
2019
Published Online:
May 2020
ISBN:
9780226638096
eISBN:
9780226638126
Item type:
chapter
Publisher:
University of Chicago Press
DOI:
10.7208/chicago/9780226638126.003.0006
Subject:
History, History of Science, Technology, and Medicine

In order to illustrate how advocates are mobilizing mutations today, this chapter delves into the patient advocacy network organized around 22q11.2 Deletion Syndrome. Activists still face a range of ... More


Advances in Attention, Genes, and Developmental Disorders: An Introduction

Kim Cornish and John Wilding

in Attention, Genes, and Developmental Disorders

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195179941
eISBN:
9780199864652
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195179941.003.0001
Subject:
Neuroscience, Behavioral Neuroscience, Development

This introductory chapter emphasizes the importance of rooting research in an interdisciplinary framework that can investigate attention across multiple levels: genetic, brain, cognitive, and ... More


Fragile X Syndrome

Tori L. Schaefer, David L. Nelson, and Craig A. Erickson

in Pediatric and Adult Nutrition in Chronic Diseases, Developmental Disabilities, and Hereditary Metabolic Disorders: Prevention, Assessment, and Treatment

Published in print:
2017
Published Online:
April 2017
ISBN:
9780199398911
eISBN:
9780199398942
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199398911.003.0056
Subject:
Public Health and Epidemiology, Public Health

This chapter discusses fragile X syndrome, including prevalence, phenotype and clinical abnormalities, molecular genetics and inheritance, factors to be considered in nutritional evaluation and ... More


Fragile X: A Family of Disorders

Ann M. Mastergeorge and Jacky Au

in Cognitive and Behavioral Abnormalities of Pediatric Diseases

Published in print:
2010
Published Online:
November 2020
ISBN:
9780195342680
eISBN:
9780197562598
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195342680.003.0024
Subject:
Clinical Medicine and Allied Health, Psychiatry

Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability known, and it is the most common single gene disorder associated ... More


Developmental systems and their dysfunction

John C. Lucchesi

in Epigenetics, Nuclear Organization & Gene Function: With implications of epigenetic regulation and genetic architecture for human development and health

Published in print:
2019
Published Online:
March 2019
ISBN:
9780198831204
eISBN:
9780191869266
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780198831204.003.0022
Subject:
Biology, Evolutionary Biology / Genetics, Biochemistry / Molecular Biology

A specific function performed by the brain is learning—new information is stored as short-term memory by the activation of the transcription factor CREB, and as long-term memory by DNA methylation ... More


Dendrites and disease

Daniel Johnston, Andreas Frick, and Nicholas P. Poolos

in Dendrites

Published in print:
2016
Published Online:
May 2016
ISBN:
9780198745273
eISBN:
9780191819735
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198745273.003.0024
Subject:
Neuroscience, Sensory and Motor Systems, Molecular and Cellular Systems

While the functional properties of dendrites in the normal brain are the main focus for this book, there is a long history of research related to changes in dendrites that are associated with certain ... More


Determinants of Synaptic and Circuit Plasticity in the Cerebral Cortex: Implications for Neurodevelopmental Disorders

Wilson Nathan R. and Mriganka Sur

in Cerebral Plasticity: New Perspectives

Published in print:
2011
Published Online:
August 2013
ISBN:
9780262015233
eISBN:
9780262295444
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262015233.003.0007
Subject:
Neuroscience, Research and Theory

This chapter deals with the control signals that command adjustments in the cortical circuits’ “plasticity status.” It outlines several “feedforward” mechanisms that can initiate circuit change, ... More


Genetics, Behavior, and Behavioral Phenotypes

James C. Harris

in Intellectual Disability: Understanding Its Development, Causes, Classification, Evaluation, and Treatment

Published in print:
2005
Published Online:
November 2020
ISBN:
9780195178852
eISBN:
9780197562284
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780195178852.003.0010
Subject:
Clinical Medicine and Allied Health, Psychiatry

Geneticists and specialists working with individuals with intellectual disability now recognize that genetic syndromes may have characteristic physical phenotypes and ... More


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