Michael W. Miller, Maria B. Bruns, and Paula L. Hoffman
- Published in print:
- 2006
- Published Online:
- January 2010
- ISBN:
- 9780195183139
- eISBN:
- 9780199865147
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195183139.003.0015
- Subject:
- Neuroscience, Development
This chapter discusses the effects of ethanol on the incidence of neuronal death and the extracellular mediators that define this death. Ethanol-induced neuronal death occurs during defined periods ...
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This chapter discusses the effects of ethanol on the incidence of neuronal death and the extracellular mediators that define this death. Ethanol-induced neuronal death occurs during defined periods of the developmental time line. These time periods coincide with those of neuronogenesis and primary synaptogenesis, which are periods of naturally occurring neuronal death (NOND). Exposure of ethanol at this time may exacerbate processes involved in NOND.Less
This chapter discusses the effects of ethanol on the incidence of neuronal death and the extracellular mediators that define this death. Ethanol-induced neuronal death occurs during defined periods of the developmental time line. These time periods coincide with those of neuronogenesis and primary synaptogenesis, which are periods of naturally occurring neuronal death (NOND). Exposure of ethanol at this time may exacerbate processes involved in NOND.
Tara A. Lindsley
- Published in print:
- 2006
- Published Online:
- January 2010
- ISBN:
- 9780195183139
- eISBN:
- 9780199865147
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195183139.003.0014
- Subject:
- Neuroscience, Development
This chapter summarizes the effects of ethanol on the outgrowth and maturation of dendrites and axons, focusing on central nervous system neurons developing in vivo or in vitro. Selected observations ...
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This chapter summarizes the effects of ethanol on the outgrowth and maturation of dendrites and axons, focusing on central nervous system neurons developing in vivo or in vitro. Selected observations highlight both well-established and emerging insights on the effects of ethanol on axonal and dendritic growth. One section describes how recent advances in developmental neural cell biology are informing work aimed at understanding the mechanisms underlying the disruption of neuronal development by ethanol.Less
This chapter summarizes the effects of ethanol on the outgrowth and maturation of dendrites and axons, focusing on central nervous system neurons developing in vivo or in vitro. Selected observations highlight both well-established and emerging insights on the effects of ethanol on axonal and dendritic growth. One section describes how recent advances in developmental neural cell biology are informing work aimed at understanding the mechanisms underlying the disruption of neuronal development by ethanol.
Sandra M. Mooney, Michael W. Miller, and George I. Henderson
- Published in print:
- 2006
- Published Online:
- January 2010
- ISBN:
- 9780195183139
- eISBN:
- 9780199865147
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195183139.003.0016
- Subject:
- Neuroscience, Development
Developmental exposure to ethanol can significantly reduce the number of neurons in specific areas of the brain, resulting in a decrease in the additive processes of cell generation and migration ...
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Developmental exposure to ethanol can significantly reduce the number of neurons in specific areas of the brain, resulting in a decrease in the additive processes of cell generation and migration and/or an increase in the substractive process of cell death. This chapter examines the effects of ethanol on intracellular pathways involved in neuronal death.Less
Developmental exposure to ethanol can significantly reduce the number of neurons in specific areas of the brain, resulting in a decrease in the additive processes of cell generation and migration and/or an increase in the substractive process of cell death. This chapter examines the effects of ethanol on intracellular pathways involved in neuronal death.
W. Michael Zawada and Mita Das
- Published in print:
- 2006
- Published Online:
- January 2010
- ISBN:
- 9780195183139
- eISBN:
- 9780199865147
- Item type:
- chapter
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195183139.003.0012
- Subject:
- Neuroscience, Development
This chapter discusses the effects of early ethanol exposure on the cell cycle, with particular reference to neuronal stem cells (NSCs) in the developing brain. Understanding how ethanol affects the ...
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This chapter discusses the effects of early ethanol exposure on the cell cycle, with particular reference to neuronal stem cells (NSCs) in the developing brain. Understanding how ethanol affects the cell cycle of NSCs might be valuable in the context of treating ethanol-induced developmental defects such as those observed in fetal alcohol spectrum disorders (FASD). NSCs and the molecular components of the cell cycle are defined before delving into the effects of ethanol on the progression of the cell cycle.Less
This chapter discusses the effects of early ethanol exposure on the cell cycle, with particular reference to neuronal stem cells (NSCs) in the developing brain. Understanding how ethanol affects the cell cycle of NSCs might be valuable in the context of treating ethanol-induced developmental defects such as those observed in fetal alcohol spectrum disorders (FASD). NSCs and the molecular components of the cell cycle are defined before delving into the effects of ethanol on the progression of the cell cycle.
