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The role of epidemiology in assessing the potential clinical impact of pharmacogenomics

David L. Veenstra

in Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease

Published in print:
2009
Published Online:
May 2010
ISBN:
9780195398441
eISBN:
9780199776023
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195398441.003.0027
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

A promising area of genomics is the use of information about genetic variation to guide drug therapy, a field known as pharmacogenomics. Pharmacogenomic applications can be broadly categorized into ... More


Pharmaceuticals Other Than Hormones

LAUREL A. HABEL and GARY D. FRIEDMAN

in Cancer Epidemiology and Prevention

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195149616
eISBN:
9780199865062
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195149616.003.0025
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses the link between therapeutic drugs and cancer. Topics covered include chemical carcinogenesis, drug safety, pharmacoepidemiologic studies, methodologic issues in studies of ... More


Intervention in high risk groups: hypertension

P. S. Sever and N. R. Poulter

in Coronary Heart Disease Epidemiology: From aetiology to public health

Published in print:
2005
Published Online:
September 2009
ISBN:
9780198525738
eISBN:
9780191724114
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198525738.003.0051
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter discusses the treatment of hypertension for preventing cardiovascular disease. Topics covered include early trials, unresolved issues in drug treatment, benefits of more contemporary ... More


Polypharmacy: The Problem with Pills

Frederick M. Barken

in Out of Practice: Fighting for Primary Care Medicine in America

Published in print:
2011
Published Online:
August 2016
ISBN:
9780801449765
eISBN:
9780801460609
Item type:
chapter
Publisher:
Cornell University Press
DOI:
10.7591/cornell/9780801449765.003.0004
Subject:
Public Health and Epidemiology, Public Health

This chapter comments on doctors' propensity to overprescribe, a practice known as polypharmacy. Polypharmacy simply means “many drugs,” and may be quite appropriate in certain cases, such as an ... More


Drug therapies

Sam H. Ahmedzai and Martin F. Muers

in Supportive Care in Respiratory Disease

Published in print:
2005
Published Online:
November 2011
ISBN:
9780192631411
eISBN:
9780191730160
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780192631411.003.0009
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology

This chapter examines different types of drugs used in the management of dyspnoea. It describes palliative drug therapies that are usually turned to when disease-orientated strategies are exhausted. ... More


Tuberculosis Undefeated

Christopher Dye

in The Population Biology of Tuberculosis

Published in print:
2015
Published Online:
October 2017
ISBN:
9780691154626
eISBN:
9781400866571
Item type:
chapter
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691154626.003.0001
Subject:
Biology, Disease Ecology / Epidemiology

This chapter provides an empirical account of the evolutionary and epidemiological history of tuberculosis in populations around the world. Much has happened in the population biology of TB since ... More


Human Immunodeficiency Virus: AIDS, the Current Plague

Michael B. A. Oldstone

in Viruses, Plagues, and History: Past, Present, and Future

Published in print:
2020
Published Online:
September 2020
ISBN:
9780190056780
eISBN:
9780197523292
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/oso/9780190056780.003.0016
Subject:
Public Health and Epidemiology, Epidemiology

This chapter explores acquired immunodeficiency syndrome (AIDS), a lethal disease cause by the human immunodeficiency virus (HIV). Of the more than 75 million people HIV has infected in the 36 years ... More


Drug Therapy and Nutrition

Marshal Shlafer and Rebecca J. Shlafer

in Pediatric and Adult Nutrition in Chronic Diseases, Developmental Disabilities, and Hereditary Metabolic Disorders: Prevention, Assessment, and Treatment

Published in print:
2017
Published Online:
April 2017
ISBN:
9780199398911
eISBN:
9780199398942
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199398911.003.0027
Subject:
Public Health and Epidemiology, Public Health

This chapter discusses the interactions of drug therapy and nutrition, including biochemical abnormalities; pharmacokinetics; and the absorption, distribution, and elimination of drugs by metabolism ... More


Paul Ehrlich's Colonial Connections: Sleeping Sickness Drug Therapy Research, 1903–1914

in Networks in Tropical Medicine: Internationalism, Colonialism, and the Rise of a Medical Specialty, 1890–1930

Published in print:
2012
Published Online:
June 2013
ISBN:
9780804778138
eISBN:
9780804781053
Item type:
chapter
Publisher:
Stanford University Press
DOI:
10.11126/stanford/9780804778138.003.0007
Subject:
History, History of Science, Technology, and Medicine

This chapter looks more closely at sleeping sickness drug therapy research, specifically the collaborative network created by Paul Ehrlich in Africa. It focuses specifically on his relationships with ... More


Therapeutic Innovation at the End of the Asylum Era

Richard P. Bentall

in Doctoring the Mind: Is Our Current Treatment of Mental Illness Really Any Good?

Published in print:
2009
Published Online:
March 2016
ISBN:
9780814791486
eISBN:
9780814739143
Item type:
chapter
Publisher:
NYU Press
DOI:
10.18574/nyu/9780814791486.003.0003
Subject:
Psychology, Developmental Psychology

This chapter explores the treatments developed during a period of innovation that followed the Second World War. The discoveries of this period revealed a constant dialectical tension in the history ... More


Drug therapy: reviewing the evidence

Michael Soyka

in Alcohol: Science, Policy and Public Health

Published in print:
2013
Published Online:
May 2013
ISBN:
9780199655786
eISBN:
9780191757082
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199655786.003.0041
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter reviews studies on drug therapy for alcohol addiction. The basic principle for treating withdrawal from alcohol is adequate sedation and seizure prophylaxis. Second-choice drugs, which ... More


Contributions to change: treatment

H. Tunstall-Pedoe

in Coronary Heart Disease Epidemiology: From aetiology to public health

Published in print:
2005
Published Online:
September 2009
ISBN:
9780198525738
eISBN:
9780191724114
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198525738.003.0050
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter considers the impact of treatment on cardiovascular disease. It argues that for the first two decades of the last half century, it is unlikely that treatment had much impact on coronary ... More


My Personalized Disease Cells

Sheldon Krimsky

in Stem Cell Dialogues: A Philosophical and Scientific Inquiry Into Medical Frontiers

Published in print:
2015
Published Online:
November 2015
ISBN:
9780231167482
eISBN:
9780231539401
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231167482.003.0013
Subject:
Biology, Bioethics

In this dialogue, Dr. Rebecca Franklin is having a conversation with Dr. Leonard Phillips, a pediatric cardiologist, and Dan Henderson, a cell biologist, regarding the promise of the “disease in the ... More


The management of fistulae

Robin Crawford

in Palliative Care Consultations in Gynaeoncology

Published in print:
2004
Published Online:
November 2011
ISBN:
9780198528067
eISBN:
9780191730351
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198528067.003.0006
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making

This chapter discusses the management of fistulae, which poses a significant problem to a patient dying of gynaecological cancer. Fistulae often develop as complications of treatment in patients ... More


The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Lara V Marks

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
book
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.001.0001
Subject:
History, History of Science, Technology, and Medicine

This book tells the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are ... More


Stanley Kubrick’s A Clockwork Orange as Art Against Torture

Carolyn Strange

in Screening Torture: Media Representations of State Terror and Political Domination

Published in print:
2012
Published Online:
November 2015
ISBN:
9780231153591
eISBN:
9780231526975
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231153591.003.0008
Subject:
Film, Television and Radio, Film

This chapter examines the relevance of Stanley Kubrick’s 1971 film A Clockwork Orange in light of the revival of torture during the global war on terror. The film’s casting choices, musical ... More


The Ethics of Human Enhancement: Understanding the Debate

Steve Clarke, Julian Savulescu, Tony Coady, Alberto Giubilini, and Sagar Sanyal (eds)

Published in print:
2016
Published Online:
November 2016
ISBN:
9780198754855
eISBN:
9780191816352
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198754855.001.0001
Subject:
Philosophy, Moral Philosophy

We humans can enhance some of our mental and physical abilities above the normal upper limits for our species with the use of particular drug therapies and medical procedures. We will be able to ... More


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